A5000838915- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Dysphagia Assessment and Management
- Psychosomatic Disorders and Their Treatments
- Tracheal and airway disorders
- Bipolar Disorder and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Childhood Cancer Survivors' Quality of Life
- Personality Disorders and Psychopathology
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Suicide and Self-Harm Studies
- Lung Cancer Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metastasis and carcinoma case studies
- Myasthenia Gravis and Thymoma
- Urologic and reproductive health conditions
- Voice and Speech Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Traumatic Brain Injury Research
- Vestibular and auditory disorders
- Gyrotron and Vacuum Electronics Research
- Sarcoma Diagnosis and Treatment
University of Turin
2020-2024
CTO Andrea Alesini
2024
Federico II University Hospital
2024
Azienda Unita' Sanitaria Locale Di Modena
2002-2023
Sapienza University of Rome
2013-2023
University of Rome Tor Vergata
2018-2023
Policlinico Umberto I
2014-2022
Telecom Italia (Italy)
2017-2022
Azienda Ospedaliero Universitario Mater Domini
2021
Istituto Ramazzini
2008-2020
We collected 75 primary pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements to better define their clinical, histologic, and immunohistochemical profile. The patient's age ranged from 42 81 years (mean 65 years), the male-to-female ratio was 9.7:1. Sixty-nine patients (92%) were smokers. Cough hemoptysis most frequent presenting symptoms. Fifty-nine (65%) died of disease: only stage significantly predicts overall survival (p = 0.0273). Microscopically, based on WHO...
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a relatively uncommon, high-grade tumor sharing several features with small-cell lung (SCLC) but currently considered as variant of non-SCLC and accordingly treated poor results. Little known about the optimal therapy LCNEC possible therapeutic molecular targets.We reviewed 83 patients pure pulmonary to investigate their clinicopathologic features, strategy, immunohistochemical expression mutational status receptor tyrosine kinases...
Introduction Research has demonstrated that patients with insomnia are at an increased risk of experiencing suicidal ideation and/or making a suicide attempt. Objectives To evaluate the relation between and behaviour. Aims examine factors associated diagnosis in admitted to Emergency Department (ED) assessed by psychiatrist charge. Methods Participants were 843 consecutively ED Sant'Andrea Hospital Rome, January 2010 December 2011. All referred psychiatrist. A clinical interview based on...
We selected a 4-stain immunopanel including thyroid transcription factor (TTF)-1, cytokeratin (CK) 7, 34βE12, and CD56/neural cell adhesion molecule (NCAM) to subclassify series of 45 pulmonary large carcinomas (LCCs) on bronchial biopsy. All cases consisted tumor proliferation with abundant cytoplasm, vesicular nuclei, prominent nucleoli. Immunohistochemically, 27 tumors (60%) were subclassified as adenocarcinoma (TTF-1+/CK7+, 24; CK7+ only, 3), 10 (22%) squamous carcinoma (34βE12+ only), 4...
We tested 418 neoplasms along the whole spectrum of primary lung tumor histotypes for epidermal growth factor receptor (EGFR) and K-ras mutations. Clinicopathologic data from 154 patients undergoing treatment with EGFR tyrosine kinase inhibitors (TKIs) were retrospectively studied. A scoring system assigning a score each positive or negative characteristic (+1, female sex, nonsmoking status, adenocarcinoma histotype, Asian ethnicity, mutation; -1, current smoker 0, male ex-smoker,...
Atypical adenomatous hyperplasia (AAH) is considered the preinvasive lesion of pulmonary adenocarcinoma, and mutations EGFR, HER2, K-ras are involved in early stage lung adenocarcinoma carcinogenesis, also predicting clinical response to anti-EGFR small molecule inhibitors. We analyzed 18 cases primary with concomitant AAH foci from 13 patients for EGFR (exons 18-21), HER2 19-20), (exon 2) by direct sequencing polymerase chain reaction. Among mutated cases, concordant or related were...
Abstract Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity their role recurrent EOC unknown. A total of 375 patients were retrospectively analyzed. The correlation between baseline NLR SII, platinum-free interval (PFI) according to first line bevacizumab treatment analyzed using logistic regression analyses adjusted patient characteristics. Subsequently SII...