A5052496190- Enhanced Oil Recovery Techniques
- Hydraulic Fracturing and Reservoir Analysis
- Nonlinear Optical Materials Studies
- Photochromic and Fluorescence Chemistry
- Drilling and Well Engineering
- Hydrocarbon exploration and reservoir analysis
- Advanced Polymer Synthesis and Characterization
- Photopolymerization techniques and applications
- Surfactants and Colloidal Systems
- Photorefractive and Nonlinear Optics
- Petroleum Processing and Analysis
- Reservoir Engineering and Simulation Methods
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced Optical Imaging Technologies
- Photonic and Optical Devices
- Advanced Fiber Laser Technologies
- Polymer Surface Interaction Studies
- Laser-Matter Interactions and Applications
- Photochemistry and Electron Transfer Studies
- Rock Mechanics and Modeling
- Oil and Gas Production Techniques
First Affiliated Hospital of Jiangxi Medical College
2023-2025
Jiangxi Provincial People's Hospital
2023-2025
China University of Petroleum, East China
2012-2024
University of Calgary
2021
Technical Institute of Physics and Chemistry
2009-2019
Academia Sinica
2018
Chinese Academy of Sciences
2008-2017
China University of Petroleum, Beijing
2007-2012
University of Chinese Academy of Sciences
2009
Beijing University of Technology
2007-2008
Abstract Photodynamic therapy (PDT) is a noninvasive protocol for the treatment of various cancers and nonmalignant diseases. Light, oxygen, photosensitizer (PS) are essential three elements in typical PDT process. Currently, there two major barriers limiting further development PDT. One issue limited tissue penetration, other lack high‐performance PSs. Therefore, newly emerging two‐photon excited (2PE‐PDT) has attracted considerable attention recent years due to its advantages such as...
Triethylene glycol functionalized coumarin derivatives 1-5 were synthesized and investigated as photosensitizers for one- two-photon excited photodynamic therapy (PDT). Their absorption, fluorescence, triplet-state quantum yields, singlet oxygen yields found to be significantly related the substituent at 7-position of ring. In vitro photocytotoxicity these toward HepG2 cells was examined compared with a clinical drug. generation reactive species (ROS), cellular uptake, intracellular...
In this study, the mechanism of physical–chemical viscosity reduction different heavy oils under ultrasonic wave is explored. Experiments and recovery excitation were carried out, optimal parameters, physical disturbance, cavitation extent oil samples determined. Based on element analysis methods, four-component analysis, gas chromatography formation water pH value test, micro-mechanism chemical structure change was analyzed. The results show that content, temperature, initial are key to...
Abstract Background Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and leading cause vision loss among diabetic individuals. Retinal pigment epithelium (RPE) cells play crucial role in the pathophysiology DR by releasing cytokines exosomal cargo, such as long non‐coding RNAs (lncRNAs), that modulate local immune responses, maintain retinal homeostasis influence macrophage polarisation. Recent studies suggest lncRNA cancer susceptibility candidate 2 (CASC2)...
A series of polyethylene glycol-functionalized benzylidene cyclopentanone dyes with varying lipid/water partition coefficients were synthesized in high yields by a simple process. Detailed characterization and systematic studies these molecules, including linear nonlinear photophysical properties, reactive oxygen yields, vitro photodynamic therapy (PDT) activities, conducted. Four exhibited good solubility PBS (>2 mg ml−1, which is sufficient for clinical venous injection), large two-photon...
One- and two-photon photophysical photochemical properties of dyes 3-DAC 4-DAC containing coumarin benzylidene cyclopentanone moieties were studied. Their ground state configurations optimized using both Hartree-Fock density functional theory (B3LYP functional) methods, excited-state calculated time-dependent theory. These two share the same formula possess similar structures, except for different bridging positions between moieties. The position was found to have a significant effect on...
Stimuli-responsive, well-defined diblock copolymers (PEG-b-PADMO) comprising poly(ethylene glycol) (PEG, DP (degree of polymerization)=45) as the hydrophilic and temperature-sensitive part poly(N-acryloyl-2,2-dimethyl-1,3-oxazolidine) (PADMO, DP=18-47) hydrophobic acid-labile self-assembled in water into spherical micelles with high aggregation number. The micellar structures thermally induced phase transitions were investigated (1)H NMR spectroscopy, light scattering, microscopy,...
A series of bis(arylidene)cycloalkanone compounds based on cyclobutanone, cyclopentanone, cyclohexanone and cycloheptanone, C4-C7, respectively, with a D-π-A-π-D structure containing the same donor acceptor but different alicyclic rings was prepared. The effects ring size photophysical, photochemical electrochemical properties these were investigated systematically. We found that an increase number carbons in central leads to changes geometry, which has significant conjugation, photophysical...
Multibranched benzylidene cyclopentanone dyes with a triphenylamine core were synthesized. Their two-photon optical properties characterized using Ti:sapphire femtosecond laser. The results showed that the absorption cross-sections (δ) of these compounds increased increasing numbers branches. largest δ value three-branched compound 3 was 3298 GM which almost six times larger than model compound, 2,5-bis-[4-(dimethylamino)benzylidene]cyclopentanone (BDMA). sensitizing efficiencies three new...
Cationic modified benzylidene cyclopentanone photosensitizers selectively photo-inactivate bacterial cells over mammalian cells.
A feasible methodology for the preparation of vesicles through self-assembly supramolecular graft copolymers (SGPs) was developed. Two types polymeric were prepared two SGPs. For first SGP, hydrophobic poly(4-vinylpyridine) (PVPy) used as main chains, and hydrophilic poly(N-vinylpyrrolidone) with carboxylic end groups (PNVP-COOH) grafted onto chains ionic interaction between pyridine groups. second poly(4-acrylamidobenzoic acid) (PABA) amino Both SGPs could self-assemble to form in aqueous...
A couple of two-photon absorption dyes containing triphenylamine groups as the electron donor were synthesized. They combined with commonly used photoacid generator N-(trifluoromethanesulfonyloxy)-1,8-naphthalimide (NIOTf) to build acid generation systems (2PAGs). The photochemical and photophysical properties these well their photosensitizing mechanism investigated. Both two have a greatly enhanced cross-section over 1000 GM. quantum yields 2PAGs measured in acetonitrile solution by...