A5002600929- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Chemical Analysis and Environmental Impact
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Thyroid Disorders and Treatments
- Cleft Lip and Palate Research
- Anesthesia and Neurotoxicity Research
- Growth Hormone and Insulin-like Growth Factors
- Craniofacial Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Gestational Diabetes Research and Management
- Pesticide and Herbicide Environmental Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Estrogen and related hormone effects
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Biotin and Related Studies
- Traditional Chinese Medicine Analysis
- Impact of Technology on Adolescents
- Water Treatment and Disinfection
- Pregnancy-related medical research
- Nuclear Receptors and Signaling
Research Triangle Park Foundation
2012-2024
Environmental Protection Agency
2013-2024
Impact Assessment
2014
Cornell University
2001
Toxicogenomic analysis of five environmental chemicals was performed to investigate the ability genomics predict toxicity, categorize chemicals, and elucidate mechanisms toxicity. Three triazole antifungals (myclobutanil, propiconazole, triadimefon) two perfluorinated [perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS)] were administered daily via oral gavage for one, three, or consecutive days male Sprague-Dawley rats at single doses 300, 175, 20, 10 mg/kg/day, respectively....
Perfluorooctanoic acid (PFOA), with diverse and widespread commercial industrial applications, has been detected in human wildlife sera. Previous mouse studies linked prenatal PFOA exposure to decreased neonatal body weights (BWs) survival a dose-dependent manner. To determine whether effects were gestational time of or subsequent lactational changes, timed-pregnant CD-1 mice orally dosed 5 mg PFOA/kg on gestation days (GD) 1-17, 8-17, 12-17, vehicle GD 1-17. had no effect maternal weight...
Health concerns have been raised because perfluorooctanoic acid (PFOA) is commonly found in the environment and can be detected humans. In rodents, PFOA a carcinogen developmental toxicant. peroxisome proliferator-activated receptor α (PPARα) activator; however, capable of inducing heptomegaly PPARα-null mouse. To study mechanism associated with toxicity, wild-type mice were orally dosed for 7 days (1 or 3 mg/kg) PPARα agonist Wy14,643 (50 mg/kg). Gene expression was evaluated using...
Thyroid hormones are critical for mammalian brain development. Thus, chemicals that can affect thyroid hormone signaling during pregnancy of great concern. Perfluorohexane sulfonate (PFHxS) is a widespread environmental contaminant found in human serum, breastmilk, and other tissues, capable lowering serum thyroxine (T4) rats. Here, we investigated its effects on the system neurodevelopment following maternal exposure from early gestation through lactation (0.05, 5 or 25 mg/kg/day PFHxS),...
Per- and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely detected in humans the environment. Exposure to perfluorooctanesulfonic acid (PFOS) or perfluorohexanesulfonic (PFHxS) was previously shown cause dark-phase hyperactivity larval zebrafish.
Many xenobiotics are identified as potential thyroid disruptors due to their action reduce circulating levels of hormone, most notably thyroxine (T4). Developmental neurotoxicity is a primary concern for disrupting chemicals yet correlating the impact chemically induced changes in serum T4 perturbed brain development remains elusive. A number thyroid-specific neurodevelopmental assays have been proposed, based largely on model hormone synthesis inhibitor propylthiouracil (PTU). This study...
Abstract Iodine is essential for the production of thyroid hormones. Perchlorate an environmental contaminant that interferes with iodine uptake into gland to reduce hormone synthesis. As hormones are critical brain development, exposure perchlorate during pregnancy concern developing fetal brain. In this study, we (1) define profiles in maternal and compartments pregnant rats response inhibition sodium-iodide symporter (NIS) by (2) expand inquiry previously limited serum include was added...
Perfluorobutyrate (PFBA) is a perfluoroalkyl acid (PFAA) found in the environment. Previous studies have indicated developmental toxicity of PFAAs (perfluorooctane sulfonate [PFOS] and perfluorooctanoate [PFOA]); current study examines that PFBA. PFBA/NH4+ was given to timed-pregnant CD-1 mice by oral gavage daily from gestational day (GD) 1 17 at 35, 175, or 350 mg/kg (chosen approximate developmentally toxic doses PFOA); controls received water. At GD 18, serum levels PFBA were 3.8, 4.4,...
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, also activated by environmental contaminants. Almost nothing is known about expression PPARs during human fetal development. This study examines PPAR, , mRNA protein in tissues. With increasing age, PPAR increased liver, but decreased heart intestine, adrenal. Adult mean did not differ was lower stomach heart. kidney spleen, lung adrenal were versus adult. liver thymus...
Severe thyroid hormone (TH) deficiency during critical phases of brain development results in irreversible neurological and cognitive impairments. The mechanisms accounting for this are likely multifactorial, not fully understood. Here we pursue the possibility that one important element is TH affects basal activity-dependent neurotrophin expression regions neural processing. Graded exposure to propylthiouracil (PTU) produced dose-dependent reductions mRNA nerve growth factor (Ngf) whole...
Adverse neurodevelopmental consequences remain a primary concern when evaluating the effects of thyroid hormone (TH) disrupting chemicals. Though developing brain is known target TH insufficiency, relationship between THs in serum and central nervous system not well characterized. To address this issue, dose response experiments were performed pregnant rats using goitrogen propylthiouracil (PTU) (dose range 0.1–10 ppm). quantified offspring at gestational day 20 (GD20) postnatal 14 (PN14),...
C57BL/6N mouse embryos exposed to hydrocortisone (HC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) develop cleft palate. An interaction between these agents produces clefts at doses which alone are not teratogenic. The glucocorticoid receptor (GR) and dioxin (AhR) mediated responses their gene expression was altered by TCDD and/or HC in palates examined on gestation day (GD) 14 Northern blot analysis situ hybridization. present study quantifies AhR, AhR nuclear translocator (ARNT), GR mRNA...