A5002762245- Mitochondrial Function and Pathology
- Chemotherapy-induced cardiotoxicity and mitigation
- Electron Spin Resonance Studies
- Per- and polyfluoroalkyl substances research
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- Pesticide Exposure and Toxicity
- Birth, Development, and Health
- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Computational Drug Discovery Methods
- Renin-Angiotensin System Studies
- Metabolomics and Mass Spectrometry Studies
- Coenzyme Q10 studies and effects
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Biochemical and Molecular Research
- Cancer Treatment and Pharmacology
- Folate and B Vitamins Research
- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- Cardiac Ischemia and Reperfusion
University of Minnesota, Duluth
2012-2022
University of North Texas
2022
University of North Texas Health Science Center
2022
University of Minnesota
2004-2021
American College of Medical Toxicology
2016-2018
Center for Neurosciences
2006
University of Coimbra
2006
Michigan State University
1977-1982
University of Iowa
1981
SUNY Upstate Medical University
1966
The perfluoroalkyl acid salts (both carboxylates and sulfonates, hereafter designated as PFAAs) their derivatives are important chemicals that have numerous consumer industrial applications. However, recent discoveries some of these compounds global distribution, environmental persistence, presence in humans wildlife, well toxicity laboratory animal models, generated considerable scientific, regulatory, public interest on an international scale. Society Toxicology Contemporary Concepts...
Although the literature is replete with QSAR models developed for many toxic effects caused by reversible chemical interactions, development of QSARs reactive chemicals lacks a consistent approach. While limitations exit, an appropriate starting-point modeling toxicity applicability general rules organic reactions and association these to cellular targets importance in toxicology. The identification plausible "molecular initiating events" based on covalent nucleophiles proteins DNA provides...
Perfluoroalkyl acids (PFAAs) are widely distributed and environmentally persistent agents whose potential toxicity is not yet fully characterized. Perfluorooctanoic acid (PFOA) perfluorooctane sulfonic elicit a number of toxicities in rodents, the most prevalent which governed by activation peroxisome proliferator-activated receptor alpha (PPARalpha). The purpose this investigation was twofold: (1) To conduct structure-activity relationship study transcriptional proliferation primary rat...