Dario L. Santos

ORCID: 0000-0003-2900-6126
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About
Contact & Profiles
Research Areas
  • Mitochondrial Function and Pathology
  • Coenzyme Q10 studies and effects
  • Horticultural and Viticultural Research
  • Healthcare and Environmental Waste Management
  • Biochemical effects in animals
  • Electron Spin Resonance Studies
  • Neuroscience and Neuropharmacology Research
  • Reproductive Physiology in Livestock
  • Cardiac Ischemia and Reperfusion
  • Reproductive System and Pregnancy
  • ATP Synthase and ATPases Research
  • Ion channel regulation and function
  • Anesthesia and Neurotoxicity Research
  • Education and Digital Technologies
  • Advanced Glycation End Products research
  • Anesthesia and Sedative Agents
  • Seaweed-derived Bioactive Compounds
  • Diet and metabolism studies
  • Sperm and Testicular Function
  • Biochemical Acid Research Studies
  • Monoclonal and Polyclonal Antibodies Research
  • Neonatal Respiratory Health Research
  • Veterinary Medicine and Surgery
  • Birth, Development, and Health
  • Plant responses to elevated CO2

University of Trás-os-Montes and Alto Douro
2011-2025

Águas de Portugal (Portugal)
2014

Universidade Federal do Recôncavo da Bahia
2014

University of Coimbra
1989-2005

Center for Neurosciences
2005

Oxidative stress plays a vital role in female fertility, yet the mechanisms regulating oxidative balance canine endometrium remain poorly understood. This study investigates dynamics of antioxidant enzyme system endometrium, focusing on superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reductase (GSR), and glutathione-S-transferase (GST), along with thiobarbituric acid reactive substances (TBARS) total cellular thiols. Enzyme activities were revealed five different...

10.1016/j.anireprosci.2025.107819 article EN cc-by Animal Reproduction Science 2025-03-05

RESUMOA segurança do paciente é essencial para a qualidade da assistência em saúde, exigindo adesão às boas práticas prevenir erros e eventos adversos. Este estudo analisou de no preparo antibióticos, por meio uma pesquisa epidemiológica transversal, abordagem quantitativo-qualitativa, com 94 profissionais enfermagem. Os dados, coletados entre abril julho 2021, avaliaram o cumprimento das diretrizes institucionais ambiente dos medicamentos. resultados indicaram desafios na completa...

10.54033/cadpedv22n5-167 article PT cc-by-nc Caderno Pedagógico 2025-03-21

Background Increased oxidative stress and changes in antioxidant capacity observed both clinical experimental diabetes mellitus have been implicated the etiology of chronic diabetic complications.Many authors shown that hyperglycemia leads to an increase lipid peroxidation patients animals reflecting a rise reactive oxygen species production.The aim study was compare susceptibility mitochondria from brain liver Goto-Kakizaki (12-month-old diabetic) rats (GK rats), model non-insulin dependent...

10.1002/dmrr.200 article EN Diabetes/Metabolism Research and Reviews 2001-01-01

Because diabetes mellitus is associated with impairment of testicular function, ultimately leading to reduced fertility, this study was conducted evaluate the existence a cause-effect relationship between increased oxidative stress in and mitochondrial antioxidant capacity. The susceptibility capacity (in terms glutathione, coenzyme Q, vitamin E content) testis preparations isolated from Goto-Kakizaki (GK) non-insulin-dependent diabetic rats Wistar control rats, 1 yr age, evaluated. It found...

10.1152/ajpcell.2001.281.3.c1023 article EN AJP Cell Physiology 2001-09-01

The antioxidant effects of carvedilol and its analog BM-910228 (also known as SB 211475) were studied in rat liver mitochondria well their action on mitochondrial bioenergetics. Carvedilol inhibited ADP/Fe(2+)-initiated lipid peroxidation (measured membranes thiobarbituric acid reactive substances oxygen consumption) with IC(50) values 10.9 0. 33 microM, respectively. Under the same conditions, value for Trolox C was 18.8 microM. At concentration range showing activity both compounds prevent...

10.1016/s0022-3565(24)39002-0 article EN Journal of Pharmacology and Experimental Therapeutics 2000-12-01

We conducted a retrospective analysis of 43 consecutive children (35 boys and 8 girls), 4-14 years age living in an urban area, who were hospitalized at the Instituto de Infectologia Emilio Ribas (Sao Paulo, Brazil) from January 1989 to December 1995 with acute illness subsequently diagnosed as leptospirosis. Epidemiologic data indicated contact contaminated water most cases (88%). The patient sera reacted strongly Leptospira interrogans serovars copenhageni (45%) icterohaemorrhagiae...

10.4269/ajtmh.1997.56.307 article EN American Journal of Tropical Medicine and Hygiene 1997-03-01

Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition potential bioactivities are largely unknown. Thus the objective of this work to obtain detailed phytochemical profile T. fragrantissimus by exhaustive ethanolic extraction aqueous decoction mimicking consumption. Extracts showed high content rosmarinic acid, luteolin-O-hexuronide eriodictyol-O-hexuronide; these were main phenolic compounds present orange...

10.1016/j.fochx.2021.100171 article EN cc-by-nc-nd Food Chemistry X 2021-11-25

Abstract Mitochondrial bioenergetics is based on the generation of protonmotive force by electron transport chain. The used mitochondria for different critical aspects its normal function, ranging from calcium accumulation to synthesis ATP. transmembrane electric potential (ΔΨ) major component and also main responsible ATP mitochondrial synthase. Although several methods can be measure ΔΨ, use tetraphenylphosphonium cation (TPP + )‐selective electrode still a method election due sensitivity....

10.1002/0471140856.tx2505s65 article EN Current Protocols in Toxicology 2015-08-01
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