A5008464521- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Angiogenesis and VEGF in Cancer
- Synthesis and Reactions of Organic Compounds
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Cytokine Signaling Pathways and Interactions
- Antioxidant Activity and Oxidative Stress
- Phytochemistry Medicinal Plant Applications
- Bee Products Chemical Analysis
- HER2/EGFR in Cancer Research
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Cancer Mechanisms and Therapy
- Essential Oils and Antimicrobial Activity
- Mitochondrial Function and Pathology
- Synthesis and Characterization of Heterocyclic Compounds
- Dye analysis and toxicity
- Botanical Research and Applications
- Berberine and alkaloids research
- Enzyme function and inhibition
- Banana Cultivation and Research
Polytechnic Institute of Bragança
2013-2024
Universidade do Porto
2024
University of Coimbra
2000-2019
Chartered Institute of Management Accountants
2018
Instituto Politécnico Nacional
2010-2014
University of Trás-os-Montes and Alto Douro
2008-2013
Institute for Biotechnology and Bioengineering
2013
University of Minho
2011
Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with individual compounds present in that are scarce. Herein, different phenolic identified and quantified all over world was evaluated. Furthermore, a structure-activity relationship (SAR) analysis molecular docking were performed, order to provide insights into mechanism action potential drugs for resistant micro-organisms.2,4-Dihydroxybenzoic protocatechuic acids higher against...
In the present work, knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order evaluate their affinity bacterial that are known targets some with different mechanism action: inhibitors cell wall synthesis, protein nucleic acids synthesis and antimetabolites. After validation molecular docking approach, virtual screening all against penicillin binding 1a (PBP1a), alanine racemase (Alr),...
Heat (HAE)- and ultrasound (UAE)-assisted extraction methods were implemented to recover anthocyanins from red raspberry. Processing time, ethanol concentration, temperature or ultrasonic power the independent variables combined in five-level rotatable central composite designs coupled with response surface methodology (RSM) for processes optimization. The yield levels of cyanidin-3-O-sophoroside (C3S) cyanidin-3-O-glucoside (C3G) monitored by gravimetric HPLC-DAD-ESI/MSn methods,...
<italic>C. vulgaris</italic> inflorescences revealed myricetin derivatives as the main compound and polar extracts higher bioactivities, preserving vaginal microbiota.
Consumers are very concerned with following a healthy diet, along some precautions that may influence environmental impact. Solanum melongena L. is one of the most consumed vegetables due to its excellent nutritional value and antioxidant action. Associated high consumption, considerable amounts agro-food wastes produced. This work targets valorization this matrix, through use bio-residues study obtention coloring pigments, applying innovative technologies. Its value, chemical composition,...
The antioxidant effects of carvedilol and its analog BM-910228 (also known as SB 211475) were studied in rat liver mitochondria well their action on mitochondrial bioenergetics. Carvedilol inhibited ADP/Fe(2+)-initiated lipid peroxidation (measured membranes thiobarbituric acid reactive substances oxygen consumption) with IC(50) values 10.9 0. 33 microM, respectively. Under the same conditions, value for Trolox C was 18.8 microM. At concentration range showing activity both compounds prevent...
Virtual screening of small molecules using molecular docking has become an important tool in drug discovery. However, large scale virtual is time demanding and usually requires dedicated computer clusters. There are a number software tools that perform AutoDock4 but they require access to Linux Also no available for performing with Vina In this paper we present MOLA, easy-to-use graphical user interface automates parallel and/or bootable non-dedicated clusters.MOLA several tasks including:...
Selective side‐chain residue flexibility is an option available on A uto D ock V ina docking software. This approach promising as it attempts to provide a more realistic ligand–protein interaction environment without unmanageable increase in computer processing time. However, studies validating this are still scarce. VEGFR‐2 (vascular endothelial growth factor receptor 2), known protein target for anti‐angiogenic agents, was used study. Four residues located the kinase site were selected and...