A5025022009- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactions of Organic Compounds
- Synthesis of Indole Derivatives
- Bioactive Compounds and Antitumor Agents
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- Synthesis of heterocyclic compounds
- Analytical Chemistry and Chromatography
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Bioactive natural compounds
- Catalytic Alkyne Reactions
- Crystal structures of chemical compounds
- Metabolomics and Mass Spectrometry Studies
- Organic Chemistry Synthesis Methods
- Photochromic and Fluorescence Chemistry
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
University of Aveiro
2013-2022
Centre de Recherche sur l'Information Scientifique et Technique
2014-2022
Rede de Química e Tecnologia
2019-2022
Purdue University West Lafayette
2018
Nankai University
2018
Chengdu University
2018
National Taiwan Normal University
2018
Bangladesh Open University
2017
University of Abou Bekr Belkaïd
2016
Not widely distributed in nature, aurones, (Z)-2-benzylidene-benzofuran-3(2H)-ones, are one of the less common and lesser-known representatives a flavonoid subclass. Nevertheless, they exhibit strong broad variety biological activities. We have combined benzofuranone part classical aurone with either chromone or coumarin scaffold which proved to feature interesting activities including antimicrobial, antiviral, anticancer, anti-inflammatory antioxidant properties. Herein we present series 26...
Abstract A one‐pot synthesis of novel benzopyran‐4‐ones is described. In a tandem reaction, organobase‐catalysed Michael addition R 1 COCH 2 COR on chromone‐3‐carboxylic acid led to decarboxylation and pyran‐4‐one ring opening the latter. This was followed by chromone‐ and/or chromanone closure resulting adducts when an ortho ‐hydroxyaryl group. Antioxidant testing 14 derivatives identified strong antiradical properties chromanones 3o – r (2.1–3.1 µmol Trolox equiv./µmol compound in DPPH...
Breast cancer is the leading cause of cancer-related death in women worldwide and a critical public health concern. Here we investigated anticancer potential effects low-molecular-weight bridgehead oxygen nitrogen-containing spiro-bisheterocycles on proliferation apoptosis human breast cell lines MCF-7 MDA-MB-231. The compounds feature hydantoin moiety attached to either diazole, isoxazole, diazepine, oxazepine or benzodiazepine via privileged tetrahedral spiro-linkage. Treatment with spiro...
The present investigation aimed to examine the therapeutic potential of new coumarin derivative bis(4-hydroxy-2H-chromen-2-one) (4HC) against breast cancer.For this purpose, effects 4HC treatment on proliferation MCF-7 cancer cells and MCF-10a non-cancerous were evaluated using a fluorescent assay. Cell cycle distribution apoptosis measured by image cytometry. expression level aromatase (CYP19A1) apoptosis-related genes determined real-time PCR.MCF-7 mammary cell was significantly decreased...
The present review deals with the C-prenylation of phenolic compounds, topic has even gained a considerable scientific attention but still poorly described in literature. A brief introduction on natural sources C-prenylated phenolics is highlighted first lines, underlining also few recent studies identification, biological applications and biosynthesis mainly C-prenylflavonoids -xanthones along other small molecules. paper majorly focusing organic synthetic aspects, throughout, hundred...
The hemi-synthesis of chiral imine, benzimidazole and benzodiazepine structures is reported by the condensation (S)-(−)-perillaldehyde, major phytochemical Ammodaucus leucotrichus subsp. essential oil, with different amine derivatives 2,3-diaminomaleonitrile, o-phenylenediamine 3-[(2-aminoaryl)amino]dimedone. reaction proceeds in situ at ambient temperature without prior isolation natural (S)-(−)-perillaldehyde. Final products precipitate ethanolic medium. 2D NMR single-crystal X-ray...
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals being reported for this purpose, particularly synthetic natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration nitromethane on key intermediate chromones. Structures were extensively studied by means 2D NMR spectroscopy single-crystal XRD. Their cytotoxicity was evaluated in vitro two breast...
The synthesis of novel heterocyclic [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids by a bimolecular reaction 2-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)phenol with an aromatic or α-bromoacetyl derivatives is described. This synthetic procedure starts from unprotected phenol.
A one‐pot diastereoselective base‐catalyzed Michael‐initiated ring‐closure (MIRC) of activated methyl ketones with 3‐bromochromones to give cyclopropa[ b ]chromanones is described. Three asymmetric centres are generated in the new ]chromanone skeleton. Stereochemistry studies based on NMR spectroscopy and single‐crystal X‐ray diffraction analysis revealed trans configuration cyclopropane ring, (1 R ,1a S ,7a )/(1 ) pair enantiomers, as was further confirmed by chiral HPLC. The use acetone...