A5103183152- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
Southern University of Science and Technology
2020-2025
Saturated carbon centers connected with sp3 hybridized atoms are ubiquitous subunits in organic molecules which play an important role pharmaceuticals, agrochemicals, material sciences. Over the past decades, transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Kumada, Negishi, Stille coupling, and Buchwald-Hartwig amination reaction) enabled sp3-sp3 coupling using nucleophiles electrophiles have been evolved into one of most tools to access such units. However,...
Abstract The development of enantioselective alkyl–alkyl cross‐couplings with coinstantaneous formation a stereogenic center without the use sensitive organometallic species is attractive yet challenging. Herein, we report intermolecular regio‐ and formal hydrofunctionalizations acrylamides, forging α‐position to newly formed C sp3 –C bond for first time. developed chiral ligand enables electronically‐reversed hydrofunctionalizations, including hydroalkylation, hydrobenzylation,...
Abstract Saturated stereogenic centers containing C(sp3)–C(sp3) bonds comprise a major portion of organic molecules. Over the past decades, transition-metal-catalyzed asymmetric cross-coupling has evolved into an efficient strategy for constructing such centers. However, reaction modes to build remain limited. Herein, nickel-catalyzed enantioselective cross-hydrodimerization between distinct alkenes enable construction alkyl–alkyl been developed. In this mode, N-acyl enamines (enamides) and...
Abstract Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid alkenes via metal‐free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for first time, allowing efficient conversion terminal internal into linear, α‐branched, α‐tertiary under mild conditions. This method provides a straightforward powerful approach to wide spectrum advanced, highly...