A5057242210- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Radiopharmaceutical Chemistry and Applications
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Lymphoblastic Leukemia research
- Advances in Oncology and Radiotherapy
- Salivary Gland Tumors Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Genital Health and Disease
- Neuroendocrine Tumor Research Advances
Norfolk and Norwich University Hospital
2024
University of East Anglia
2024
University of Missouri
2021
University of California, San Francisco
2004-2020
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2019
Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya
2011
University of Southern California
2003-2006
University of Virginia
2005
University of Vermont
2005
RTOG Foundation
2005
To describe the functional outcomes of weight loss and eating following a targeted chemoradiation protocol consisting selective supradose intra-arterial cisplatin (150 mg/m2 per week for 4 weeks) with parenteral sodium thiosulfate external-beam irradiation (1.8-2.0 Gy fraction day 35 days).Forty-seven patients advanced head neck cancer treated were monitored status before treatment as long 18 months after treatment.A statistically significant (P<.001) occurred during protocol, mean ratio 90%...
To determine the feasibility of high-dose intra-arterial (IA) cisplatin and concurrent radiation therapy (RT) for head neck squamous cell carcinoma in multi-institutional setting (Multi-RADPLAT).Eligibility included T4 oral cavity, oropharynx, hypopharynx, or larynx. Patients received (150 mg/m(2) IA with sodium thiosulfate 9 g/m(2) intravenous [IV], followed by 12 IV over 6 hours, weekly 4 weeks) RT (70 Gy, 2.0 Gy/fraction, daily 5 days 7 weeks). Between May 1997 December 1999, 67 patients...
Background Squamous cell carcinoma of the pyriform sinus is an unfavorable disease which frequently presents in advanced stages. Despite aggressive “standard treatment” involving debilitating surgery and postoperative radiation therapy treatments, survival functional outcome for remains poor. Hence, we reviewed our experience management using “organ preservation” chemoradiation therapy. Methods Twenty-five patients diagnosed with stage III/IV squamous treated supradose, intra-arterial...
To determine the efficacy of targeted chemoradiation with radiation plus platinum (RADPLAT) protocol and planned selective neck dissection in patients N2 to N3 nodal disease associated upper aerodigestive tract carcinoma.Analysis 52 N2a, N2b, or involving 60 heminecks treated intraarterial cisplatin, 150 mg/m2, intravenous sodium thiosulfate, 9 g/m2, on days 1, 8, 15, 22; therapy, 180 200 cGy per fraction for 35 fractions (total dose, 68-74 Gy); (33 procedures were selective).Of 56 evaluable...
While emotional intelligence and effective team leadership undoubtedly interconnect, the nature of this relationship remains nebulous. Prominent theories attempt to elucidate how a leader's grasp emotions may cultivate cohesion productivity amongst diverse workforce. By internalizing self-awareness regulating interpersonal dynamics, practitioners acuity foster understanding across perspectives. A mastery social awareness management allows visionaries navigate disparate viewpoints on global...
<h3>Objective:</h3> To pilot a targeted chemoradiation protocol for patients with advanced carcinoma of the larynx and pharynx that would circumvent upper aerodigestive tract dysfunction related to major oncologic surgery. <h3>Design:</h3> Weekly intra-arterial infusions supradose cisplatin (150 mg/m<sup>2</sup>per week ×4) rapidly delivered tumor bulk, simultaneous intravenous sodium thiosulfate systemic drug neutralization, conventional external-beam irradiation (1.80-2.00 Gy per fraction...
BACKGROUND The impact of sequential trimodality therapy on the pattern first site disease failure in pathologic Stage IIIA (N2) nonsmall cell lung carcinoma (NSCLC) was analyzed. METHODS Seventy-four eligible patients with histologically documented NSCLC underwent Cancer and Leukemia Group B (CALGB) Protocol 8935. Treatment consisted 2 cycles induction cisplatin at 100 mg/m2 intravenously (i.v.) (Days 1 29) vinblastine 5 i.v. weekly for weeks followed by surgery. Surgery included a...
Thirty-nine patients with cutaneous T cell lymphoma (CTCL; including mycosis fungoides or the Sezary syndrome) no previous treatment other than topical therapy oral corticosteroids, received total skin electron beam irradiation (TSEB) and either sequential simultaneous systemic chemotherapy. Median follow-up, measured from time of initiation to analysis, is in excess 6 years extends 100+ months. Thirteen stage I disease (limited adenopathy) 3,000 rad followed by three 2-week courses daily...
A phase I trial was conducted to determine the maximally tolerated dose (MTD) of concurrent weekly docetaxel and three-dimensional conformal radiation therapy (3-D CRT) in unfavorable localized adenocarcinoma prostate.Patients with prostate underwent daily 3-D CRT a total 70.2 Gy at 1.8 Gy/fraction given once week for 8 9 weeks. The initial level 5 mg/m(2) doses were escalated as follows: 8, 12, 16, 20, 25 mg/m(2).Between January 2000 August 2002, 22 men completed chemoradiation protocol....
Background and Objectives CALGB 8935 was a phase II protocol for mediastinoscopically staged IIIA (N2) non-small cell lung cancer. Induction cisplatin/vinblastine chemotherapy followed by surgical resection, adjuvant cisplatin/vinblastine, radiotherapy. We now evaluate the prognosis of pathologic nodes. Methods Failure-free survival calculated from landmark 3 months after resection to account heterogeneity in therapy. Results Nine 42 (21%) resected patients had no residual N2 disease. This...
Pancreatic cancer is one of the leading causes death. The treatment options in pancreatic remain limited. This review provides an overview role radiotherapy (RT) alone or combination with systemic at different settings strategy. Neoadjuvant chemoradiotherapy (CRT) may downstage borderline resectable disease and make resection possible, which could translate to a survival benefit. Although benefit adjuvant CRT remains controversial due inconsistent outcome randomized trials, North America it...
Although docetaxel is not recommended when managing men with unfavorable-risk prostate cancer (PC) given negative or inconclusive results from previous randomized trials, unstudied benefits may exist.Between September 21, 2005, and January 13, 2015, we randomly assigned 350 1:1 T1c-4N0M0 PC to receive radiation therapy (RT) androgen deprivation (ADT) plus (60 mg/m2 once every 3 weeks for three cycles before RT 20 weekly during RT) versus ADT + RT. We evaluated the treatment effect of adding...
Background: Invasion of bony or cartilaginous structures by advanced upper aerodigestive tract cancer has been considered an indication for surgery on the basis historic experience poor responsiveness to radiation therapy.At University Tennessee-Memphis, patients with head and neck have treated a protocol concomitant intra-arterial (targeted) cisplatin conventional therapy.Objective: To compare efficacy, in terms disease control survival, this T4 squamous cell cancers invasion (group 1;...
<h3>Objective</h3> To determine the effectiveness of a cytoreduction strategy for oral cancer using novel trimodal therapy. <h3>Methods</h3> Prospective analysis 25 patients treated between October 1995 and June 2000 with protocol named neo-RADPLAT consisting 4 weekly intra-arterial infusions cisplatin (150 mg/m<sup>2</sup>) intravenous sodium thiosulfate (9 g/m<sup>2</sup>), concurrent radiation therapy (2 daily doses 50 Gy) followed by tumor nidusectomy (a conventional surgery) at 8 weeks....