A5081666534- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Photoreceptor and optogenetics research
- Magnetic properties of thin films
- Retinal Development and Disorders
- Light effects on plants
- Physiological and biochemical adaptations
- Insect Utilization and Effects
- Underwater Vehicles and Communication Systems
- Quantum and electron transport phenomena
- Human-Automation Interaction and Safety
- Nuclear Receptors and Signaling
- Insect Resistance and Genetics
- Ethics and Social Impacts of AI
- Physics of Superconductivity and Magnetism
- Cellular transport and secretion
- Congenital gastrointestinal and neural anomalies
- Semiconductor materials and devices
- Reinforcement Learning in Robotics
- Innovation, Technology, and Society
- Neuroethics, Human Enhancement, Biomedical Innovations
- Insect and Pesticide Research
- Healthcare Technology and Patient Monitoring
- Digestive system and related health
- Invertebrate Immune Response Mechanisms
University of Bremen
2019-2023
German Research Centre for Artificial Intelligence
2022
University Medical Center Hamburg-Eppendorf
2017-2021
Universität Hamburg
2003-2021
ABSTRACT Mapping brain function to structure is a fundamental task for neuroscience. For such an endeavour, the Drosophila larva simple enough be tractable, yet complex interesting. It features about 10,000 neurons and capable of various taxes, kineses Pavlovian conditioning. All its are currently being mapped into light-microscopical atlas, Gal4 strains generated experimentally access one at time. In addition, electron microscopic reconstruction nervous system seems within reach. Notably,...
Expression of the Ret receptor tyrosine kinase is a defining feature enteric neurons. Its importance underscored by effects its mutation in Hirschsprung disease, leading to absence gut innervation and severe gastrointestinal symptoms. We report new physiologically significant site expression intestine: intestinal epithelium. Experiments Drosophila indicate that expressed both neurons adult epithelial progenitors, which require sustain their proliferation. Mechanistically, engaged positive...
Dendritic arborization is highly regulated and requires tight control of dendritic growth, branching, cytoskeletal dynamics, ion channel expression to ensure proper function. Abnormal development can result in altered network connectivity, which has been linked neurodevelopmental disorders, including autism spectrum disorders (ASDs). How neuronal growth programs tune function still not fully understood. Using Drosophila (da) neurons as a model, we identified the conserved Ste20-like kinase...
Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) also feature complete space-filling growth dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as developmental signal promoting through Ret receptor. Both necessary radial spreading C4da neuron...
Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This date achieved by the regulation of ion flow electrical signals in neuronal cells neural circuits that are known be affected disease. In contrast, optogenetic delivery trophic biochemical signals, which support cell survival implicated degenerative disorders, never demonstrated an animal model Here, we reengineered human Drosophila melanogaster REarranged during Transfection (hRET...
Drosophila melanogaster larvae have been extensively used as a model to study the molecular and cellular basis of nociception. The larval nociceptors, class IV dendritic arborization (C4da) neurons, line body wall animal respond various stimuli including noxious heat touch. Activation C4da neurons results in stereotyped escape behavior, characterized by 360° rolling response along axis followed locomotion speedup. genetic accessibility has allowed identification mechanosensory channels...
Thermo-nociception, the detection and behavioral response to noxious temperatures, is a highly conserved action avoid injury ensure survival. Basic molecular mechanisms of thermal responses have been elucidated in several model organisms are clinical relevance as hypersensitivity (thermos-allodynia) common neuropathic pain syndromes. Drosophila larvae show stereotyped escape behavior upon heat stimulation, which can be easily quantified coupled with genetic approaches. It has successfully...
Abstract Optogenetics has been harnessed to shed new mechanistic light on current therapies and develop future treatment strategies. This date achieved by the correction of electrical signals in neuronal cells neural circuits that are affected disease. In contrast, optogenetic delivery trophic biochemical signals, which support cell survival thereby may modify progression degenerative disorders, never demonstrated an animal disease model. Here, we reengineered human Drosophila melanogaster...
Summary form only given. The magnetic properties of nanostructured ferromagnets are important for storage applications and magnetoelectronic devices where spin transport phenomena utilized. latter effects crucially depend on the domain configuration. Magnetostatic interaction between via stray fields might have an impact formation switching properties. Using a Hall nanomagnetometer as local probe, we investigated ferromagnetic nanostructures which been prepared by means electron-beam...