A5035876563- Inflammatory Biomarkers in Disease Prognosis
- Ovarian cancer diagnosis and treatment
- Platelet Disorders and Treatments
- Advanced Breast Cancer Therapies
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Nutritional Studies and Diet
- Inflammatory mediators and NSAID effects
- Menopause: Health Impacts and Treatments
- Heat shock proteins research
- Lung Cancer Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Cholesterol and Lipid Metabolism
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Hormonal Regulation and Hypertension
- Genetics, Aging, and Longevity in Model Organisms
- PARP inhibition in cancer therapy
University of Oklahoma Health Sciences Center
2019-2025
OU Health Stephenson Cancer Center
2023
Oklahoma City University
2020
University of Nebraska–Lincoln
2017
University of Michigan
2016-2017
Patients with ovarian cancer commonly experience metastases and recurrences, which contribute to high mortality. Our objective was better understand metastasis identify candidate biomarkers drug targets for predicting preventing recurrence. Transcripts of 770 cancer-associated genes were compared in cells collected from ascitic fluid versus resected tumors an ES-2 orthotopic mouse model. Associated cell types pathways explored bioinformatics. FGF7 protein measured using capillary-based...
The literature on the relationships among blood iron levels, cognitive performance, and brain levels specific to women at menopausal transition is ambiguous best. need better understand these potential in for whom monthly loss (and thus loss) ceasing highlighted by fact that accumulates tissue over time accumulation thought be a factor development of neurodegenerative disease. Non-anemic who were either low or had normal their age race/ethnicity provided samples, underwent MRI scans estimate...
The literature on the relationships among blood iron levels, cognitive performance, and brain levels specific to women at menopausal transition is ambiguous best. need better understand these potential in for whom monthly loss (and thus loss) ceasing highlighted by iron's accumulation tissue over time, thought be a factor development of neurodegenerative disease. Non-anemic who were either low or had normal their age race/ethnicity provided samples, underwent MRI scans estimate performed set...
Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a strategy targeted at missense mutant p53, we hypothesized that the release of p53 from mortalin inhibition SHetA2 drug combined with reactivation PRIMA-1MET inhibits growth tumor establishment synergistically in mutant-p53 dependent manner. The Cancer Genome Atlas (TCGA) data serous tumors were evaluated for TP53 HSPA9/mortalin status. tested cell lines fallopian tube...
Key Points The antiplatelet effects of 12-HETrE in humans and mice are partly dependent on IP vitro. antithrombotic partially vivo mice.
Increasing evidence is implicating roles for platelets in the development and progression of ovarian cancer, a highly lethal disease that can arise from fallopian tubes, has no current method early detection or prevention. Thrombosis major cause mortality cancer patients suggesting alters platelet behavior. The objective this study was to develop cell culture model pathological interactions human cells, using normal FT epithelial cells as healthy control, test effects anti-platelet...
Patients with ovarian cancer have high platelet counts, which correlate disease burden, incidence, and lethality of blood clots (thrombosis). We hypothesized that elevated aggregation is associated both increased number altered behavior platelets in patients cancer.
Cervical cancer is caused by high-risk human papillomavirus (HPV) types and treated with conventional chemotherapy surgery and/or radiation. HPV E6 E7 proteins increase phosphorylation of retinoblastoma (Rb) cyclin D1/cyclin dependent kinase (CDK)4/6 complexes. We hypothesized that D1 degradation the SHetA2 drug in combination palbociclib inhibition CDK4/6 activity synergistically reduces phosphorylated Rb (phospho-Rb) inhibits cervical growth. The effects these drugs, alone, combination,...
Platelets have been shown to promote ovarian cancer; however, the mechanism is poorly understood. Previously, we demonstrated that platelets reduce size and increase density of multi-cellular cancer spheroids in cell cultures. The objectives this study were determine if platelet inhibitors could counteract these effects, explore mechanisms involved.
ABSTRACT Cervical cancer is predominantly driven by persistent infections with high‐risk human papillomavirus and the continuous activity of its E6 E7 oncoproteins. This study explored role heat shock proteins 70 kDa (HSP70s) in enhancing function these oncoproteins examined impact SHetA2, an investigational new drug, on this interaction. We found that HSP70 specifically binds to E7, but not E6, protein SHetA2 disrupts binding. disruption led a significant reduction mRNA levels, while...
<h3>Introduction</h3> While recent advances in ovarian cancer therapy have improved patient's lives, current therapies are highly toxic. We developed sulfur heteroarotinoid A2 (SHetA2), a non-toxic drug currently Phase 1 trial. SHetA2 causes cyclin D1 degradation and cyclin-dependent kinases 4 6 (CDK4/6) from protection by heat shock cognate 70 protein, causing G1 cell cycle arrest. Abemaciclib is kinase (CDK) inhibitor used to treat breast cancer. hypothesized that combination of...
The antithrombotic effect of dihomo‐γ‐linolenic acid (DGLA), an ω‐6 fatty acid, was recently shown to be dependent upon 12‐lipoxygenase (12‐LOX) and its DGLA‐derived metabolite, 12‐hydroxy‐eicosatrienoic (12‐HETrE). 12‐HETrE inhibits platelet activation via the Gα s signaling pathway; however, ‐coupled receptor by which mediates antiplatelet effects has yet identified. We hypothesized that exerts through a known lipid binding prostanoid expressed platelets: IP, EP 2 , 4 or DP 1 . In this...
Background: The majority of high-grade serous ovarian cancer patients are diagnosed at late stage and recur after primary chemotherapy cytoreductive surgery. Our objective was to test low-toxicity drug combinations prevent tumor establishment. SHetA2 is a novel small molecule that exhibited in vivo colorectal prevention activity, reasonable oral bioavailability pharmacokinetics lack toxicity extensive preclinical studies. binding its HSPA9 target (mortalin) causes release nuclear...
Abstract Background: The majority of high-grade serous ovarian cancer patients are diagnosed at late stage and recur after primary chemotherapy cytoreductive surgery. Our objective was to test low-toxicity drug combinations prevent tumor establishment. SHetA2 is a novel small molecule that exhibited in vivo colorectal prevention activity, reasonable oral bioavailability pharmacokinetics lack toxicity extensive preclinical studies. binding its HSPA9 target (mortalin) causes release nuclear...
Abstract Background: Cancer is the second leading cause of deaths worldwide after cardiovascular diseases. A commonality between cancer and diseases disregulation platelets. Platelets are known to promote each other in a feedforward mechanism that poorly understood. long chain polyunsaturated fatty acids dihomo-gamma-linolenic acid (DGLA) was shown reduce events platelet dependent manner while exact DGLA-mediated cells death yet be explored. Objectives: The objective our study develop an...
A third of ovarian cancer patients have high platelet counts at diagnosis resulting in reduced survival compared to with low/normal counts. Current studies suggest that platelets and induce each other a feed-forward loop.The objectives were to: 1) evaluate differences aggregation between healthy newly-diagnosed patients; 2) develop an experimental model the pathological interactions spheroids; 3) identify pathways affected by these ways intervene. Our hypothesis is are associated...
<h3>Objectives</h3> Thrombocytosis in ovarian cancer patients directly correlates with disease burden and increased risk of thrombosis death caused by thrombosis. The objective the current study was to test hypothesis that agonist-induced platelet aggregation differs between healthy controls compared based on count or cancer-altered biology. <h3>Methods</h3> Venous blood collected from (N>25 each) acid citrate dextrose anticoagulant. Complete counts (CBCs) whole samples were determined...
Introduction Cervical cancer is caused by high-risk human papillomavirus (HPV) and treated with conventional chemotherapy combined surgery and/or radiation. HPV oncoproteins increase retinoblastoma (Rb) phosphorylation cyclin D1/cyclin dependent kinase (CDK)4/6 complexes cellular proliferation. We hypothesized that D1 degradation the SHetA2 drug in combination palbociclib inhibition of CDK4/6 activity synergistically reduces Rb inhibits cervical growth. Methods The effects these drugs,...