A5086131245- Fullerene Chemistry and Applications
- Advanced Chemical Physics Studies
- Advanced NMR Techniques and Applications
- Astrophysics and Star Formation Studies
- Graphene research and applications
- Organometallic Complex Synthesis and Catalysis
- Innovative Human-Technology Interaction
- Quantum, superfluid, helium dynamics
- Magnetism in coordination complexes
- Particle Detector Development and Performance
- Synthetic Organic Chemistry Methods
- Southeast Asian Sociopolitical Studies
- Single-cell and spatial transcriptomics
- Usability and User Interface Design
- International Development and Aid
- Calibration and Measurement Techniques
- Astronomical Observations and Instrumentation
- Technology Use by Older Adults
- Conducting polymers and applications
- Hemoglobin structure and function
- Advanced Battery Materials and Technologies
- Cancer survivorship and care
- Global Financial Crisis and Policies
- Personal Information Management and User Behavior
- Synthesis and Properties of Aromatic Compounds
Dana-Farber Cancer Institute
2022-2025
Yale University
2024
University of Washington Medical Center
2024
Duke University
2023
Hong Kong Lung Foundation
2023
New York Proton Center
2016-2020
University of Guelph
2019
Faculty of 1000 (United States)
2017
University of California, Irvine
2008-2014
Columbia University
2008-2013
Protein kinase C-ζ (PKC-ζ) is a serine/threonine downstream from phosphatidylinositol 3-kinase in insulin signaling pathways. However, specific substrates for PKC-ζ that participate the biological actions of have not been reported. In present study, we identified receptor substrate-1 (IRS-1) as novel substrate PKC-ζ. Under vitro conditions, wild-type (but kinase-deficient mutant PKC-ζ) significantly phosphorylated IRS-1. This phosphorylation was reversed by treatment with serine-specific...
Inelastic neutron scattering, far-infrared spectroscopy, and cryogenic nuclear magnetic resonance are used to investigate the quantized rotation ortho–para conversion of single water molecules trapped inside closed fullerene cages. The existence metastable ortho -water is demonstrated, interconversion -and para spin isomers tracked in real time. Our investigation reveals that ground state encapsulated has a lifted degeneracy, associated with symmetry-breaking environment.
Among glycoprotein hormone receptors the TSH receptor (TSHR) in most susceptible to constitutive by mutations various regions of molecule, including extracellular domain (ECD) and loops transmembrane (TMD) understand role hte ECD TSHR activation we have tested several constructs with major deletions ECD. Previous studies reported very low expression such truncated receptors, which prevented reliable assessment their ligand-binding basal activities. We eliminated this problem using at its...
We have measured the temperature dependence of infrared spectra a hydrogen molecule trapped inside C60 cage, H2@C60, in range from 6 to 300 K and analyzed excitation spectrum by using five-dimensional model vibrating rotor spherical potential. The electric dipole moment is induced translational motion endohedral H2 gives rise an absorption process where one quantum created or annihilated, ΔN = ±1. Some fundamental transitions, 0, are observed as well. rotation unhindered but coupled motion....
The interconversion of the two allotropes hydrogen molecule (para-H2 and ortho-H2) incarcerated inside fullerene C60 is reported (oH2@C60 pH2@C60, respectively). For conversion, oH2@C60 was adsorbed at external surface zeolite NaY immersed into liquid oxygen 77 K. Equilibrium reached in less than 0.5 h. Rapid removal provides a sample enriched pH2@C60 that stable for many days absence paramagnetic catalysts (half-life approximately 15 days). Enriched nonvolatile soluble organic solvents. At...
Ni takes a load off: Nickel(0) and strained alkene react to form stable tris(alkene) complex, which eliminates the corresponding trans,trans,trans-cyclobutane upon heating. A higher proportion of Ni0 precursor yielded first all-alkyl complex nickel(IV) (see structure; Ni: green). These reactions, involve ligand coupling, are driven by relief ring strain in alkene. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not...
We report an inelastic neutron-scattering (INS) investigation of coupled quantum translation and rotation hydrogen molecules trapped inside the closed isotropic cages ${\text{C}}_{60}$. The low-lying states that characterize translation-rotation manifold are accurately determined in our study INS peak energies. A comparison between spectra ${\text{H}}_{2}$ HD isotopomers provides quantitative insight into coupling rotational translational angular momentum with exhibiting strongest effects...
The quantum dynamics of dihydrogen molecules entrapped inside fullerene cages has been investigated using inelastic neutron scattering (INS). For the endofullerene H${}_{2}$@C${}_{60}$ low-lying energy levels manifold coupled translational and rotational states have accurately determined by studying INS spectra recorded in temperature range $1.5\ensuremath{\leqslant}T\ensuremath{\leqslant}240\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. majority transitions observed interconvert nuclear spin...
A 15N-labeled nitroxide was incarcerated into an octa acid nanocapsule, which confirmed by 1H NMR and EPR spectroscopy. Electron paramagnetic interaction between the a 14N-labeled free in external aqueous solution observed The observation of spin−spin interaction, through walls carcerand is reflected simultaneous line-broadening both nitroxides. computer-assisted analysis data further provides direct information on motion polarity nitroxides bulk phase. We also show how communication guest...
Abstract Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial cellular map 67 biopsies from 60 patients with breast cancer across diverse clinicopathological features nine anatomic sites detailed clinical annotations. We combined single-cell or single-nucleus RNA sequencing for all panel four expression assays...
Spin−lattice relaxation times, T1, have been measured from 200−340 K for the protons in H2 and HD molecules dissolved toluene-d8 incarcerated C60. It is found that relaxes more slowly than both environments at all temperatures, as expected smaller values of spin-rotation dipole−dipole coupling compared to H2. More detailed analysis using models developed describe condensed media gas phase indicates transitions among rotational states occur a rate similar those solution C60, contrast...
The successful synthesis of H2O@C60 makes possible the study magnetic interactions an isolated water molecule in a geometrically well-defined hydrophobic environment. Comparisons are made between T1 values and previously studied H2@C60 their nitroxide derivatives. value is approximately six times longer for than at room temperature, independent solvent viscosity or polarity, increases monotonically with decreasing implying that dominated by spin-rotation interaction. Paramagnetic nitroxides,...
The quantum dynamics of a hydrogen molecule encapsulated inside the cage C60 fullerene is investigated using inelastic neutron scattering (INS). emphasis on temperature dependence INS spectra which were recorded time-of-flight spectrometers. endofullerene system highly mechanical, exhibiting both translational and rotational quantization. profound influence Pauli exclusion principle revealed through nuclear spin isomerism. shown to be exceptionally able drive transitions between...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent deuterium isotope effect on the liver alcohol dehydrogenase reactionJack Schmidt, Judy Chen, Michael DeTraglia, Daniel Minkel, and James T. McFarlandCite this: J. Am. Chem. Soc. 1979, 101, 13, 3634–3640Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ja00507a033https://doi.org/10.1021/ja00507a033research-articleACS PublicationsRequest reuse...
The interconversion of ortho-hydrogen (oH2) and para-hydrogen (pH2), the two nuclear spin isomers dihydrogen, requires a paramagnetic catalyst such as nitroxide. We report design demonstration catalysis oH2 pH2 incarcerated in an endofullerene based on reversible nitroxide/hydroxylamine system. system is example magnetic switch that can increase rate H2 by factor ∼104.
The oxygen-enhanced photoconductivity observed in crystalline rubrene is investigated using electron paramagnetic resonance (EPR) spectroscopy and steady-state time dependent (PC) measurements. EPR data indicate the presence of radical cation oxygen anion pairs formed within structure when irradiated oxygen. Radical lifetimes determined correlate well with transient PC provide strong evidence that charge carrier responsible for enhanced conduction. This process reversible, although...
Design and evaluation of user-generated media production sharing in Human-Computer Interaction (HCI) often focus on formal informal sharing, such as communication within social networks, automatic notifications activities, the exchange digital artifacts. However, conceptual tools for understanding how people relate to audiences they reach through these systems are limited. The increasing interest content HCI demands infusion new methods theories that explicitly engage construction use among...
N-linked glycosylation represents a structurally diverse, complex, co- and posttranslational protein modification that bridges metabolism cellular signaling. Consequently, aberrant is hallmark of most pathological scenarios. Due to their complex nature non-template-driven synthesis, the analysis glycans faced with several challenges, underlining need for new improved analytical technologies. Spatial profiling N-glycans through direct imaging on tissue sections reveals regio-specific and/or...
The stoichiometric reduction of N-carbophenoxypyridinium tetraphenylborate (6) by CpRu(P−P)H (Cp = η5-cyclopentadienyl; P−P dppe, 1,2-bis(diphenylphosphino)ethane, or dppf, 1,1′-bis(diphenylphosphino)ferrocene), and Cp*Ru(P−P)H (Cp* η5-pentamethylcyclopentadienyl; dppe) gives mixtures 1,2- 1,4-dihydropyridines. 6 Cp*Ru(dppf)H (5) only the 1,4-dihydropyridine, 5 catalyzes exclusive formation 1,4-dihydropyridine from 6, H2, 2,2,6,6-tetramethylpiperidine. In reductions, ratio 1,4 to 1,2 product...