A5065249087- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Neutropenia and Cancer Infections
- Microbial infections and disease research
- Plant-Microbe Interactions and Immunity
- Sulfur-Based Synthesis Techniques
- Bird parasitology and diseases
- Infectious Diseases and Mycology
- Organoselenium and organotellurium chemistry
- Cystic Fibrosis Research Advances
- Leptospirosis research and findings
- Organic Chemistry Cycloaddition Reactions
- Oral microbiology and periodontitis research
- Bacterial Identification and Susceptibility Testing
- Avian ecology and behavior
- Cytomegalovirus and herpesvirus research
- Oral health in cancer treatment
- Turtle Biology and Conservation
- Rabies epidemiology and control
- Women's cancer prevention and management
- Organometallic Compounds Synthesis and Characterization
- Bioactive Compounds and Antitumor Agents
- Vascular Malformations and Hemangiomas
Universidade Federal do Rio Grande
2020-2025
Diphenyl diselenide (PhSe)2 is a stable organoselenium compound with promising in vitro antifungal activity against several fungi, including Sporothrix brasiliensis. This species associated feline and zoonotic sporotrichosis, an emergent mycosis Latin America. We evaluated the of (PhSe)2, alone association itraconazole, treatment sporotrichosis caused by S. brasiliensis, murine model. Sixty mice were subcutaneously infected brasiliensis footpad treated gavage for 30 consecutive days. The six...
Sporotrichosis caused by Sporothrix brasiliensis is a global emergent infectious disease. Due to the scarcity of therapeutic options for fungal diseases, new antifungals are urgently needed. Nikkomycin Z (NikZ) future option as an agent against dimorphic fungi. We evaluated NikZ monotherapy and in combination with itraconazole (ITZ; conventional therapy) treatment experimental sporotrichosis S. murine model. Animals were subcutaneously infected, treated orally 30 days. The study groups...
Sporotrichosis is a disease not requiring jurisdictional notification and consequently underreported in Brazil. Therefore, the epidemiological picture even hyperendemic states unknown. Thus, we evaluated occurrence of sporotrichosis throughout territory southern state Brazil, Rio Grande do Sul (RS).We update situation region this describe emergence Metropolitan region. We engaged professionals from RS enrolled animal health care answering questionnaire regarding sporotrichosis.The local...
Given the few antifungal classes available to treat aspergillosis, this study aimed evaluate in vitro activity of diphenyl diselenide (PhSe)2 alone and combination with classical antifungals against Aspergillus spp., its vivo a systemic experimental aspergillosis model. We performed broth microdilution assay 32 isolates; checkboard test interaction compound itraconazole (ITC), voriconazole (VRC), amphotericin B (AMB), caspofungin (CAS), nine isolates. An model invasive mice was studied,...
We evaluated the mortality due to aspergillosis in free-ranging Magellanic penguins during their migration and reproductive season. A total of 98 carcasses were collected along 370 km coastline Southern Brazil, between June 2017 October 2019, from colonies Patagonian Argentina, January 2019. All animals necropsied, only proven cases computed. Aspergillosis was diagnosed 2.5% route. Our study, coast is first demonstrate that an important cause penguins. The implications these findings One...
Sporotrichosis caused by Sporothrix brasiliensis is a globally emerging infectious disease with limited therapeutic options. Thus, we aimed to evaluate the in vitro activity of amlodipine (AML) and lufenuron (LUF) alone their interaction itraconazole (ITZ), first-choice drug against S. brasiliensis.Twenty clinical isolates from two hyperendemic regions were tested through microdilution assay minimal inhibitory concentration (MIC) fungicidal (MFC) AML LUF. Checkerboard was performed 10 for...
Subject: We aimed to evaluate the recovery rate of Sporothrix spp. isolates maintained for years through mineral oil technique. Methods: Two hundred and seventeen from fungal collection Mycology Laboratory Faculdade de Medicina - Universidade Federal do Rio Grande (FAMED-FURG), Southern Brazil, with a mean period storage five years, were included in study. Isolates subcultured duplicate on Sabouraud dextrose agar brain heart infusion agar. Results: Of 217 isolates, only 16.6% (n = 36)...
Abstract Zoonotic sporotrichosis caused by Sporothrix brasiliensis is an emerging mycosis in Latin America. One of the problems to quickly treat infected animals and break transmission chain associated with time-consuming gold-standard diagnosis method (culture). We aimed evaluate a species-specific polymerase reaction (PCR) for S. using non-invasive samples. performed retrospective cross-sectional study samples collected swabs from humans cats clinical suspicion sporotrichosis....
Abstract We report a series of invasive pulmonary aspergillosis in green turtles (Chelonia mydas) on the southern coast Brazil. During 13-month period, seven animals were recovered coastal beach and sent to rehabilitation center, dying after period captivity up 27 days. Granulomatous nodules lung, with presence hyaline septate hyphae, found all. Invasive was confirmed by real-time Polymerase Chain Reaction (PCR). Our study is first describe Aspergillus sp. infection turtles. Prospective...
Abstract Poster session 2, September 22, 2022, 12:30 PM - 1:30 Feline and zoonotic sporotrichosis has been described since the 1990s in Rio Grande do Sul state (RS), southern Brazil. In reported cases, this region second-highest number of cases proven due to Sporothrix brasiliensis country. Objective We update current situation Southern Brazil report measures taken face epidemiological threat over 12 years. Methods Activities developed by Laboratory Mycology Universidade Federal...
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 Aspergillosis is an opportunistic fungal disease caused by the Aspergillus genus, mostly section Fumigati. Captive Magellanic penguins are vulnerable to infection, being this mycosis a limiting factor during process of rehabilitation with mortality rate around 50%. Objectives Giving scarce data regarding occurrence aspergillosis in non-captive penguins, we aimed evaluate proportional free-ranging their migration and reproductive...
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 Invasive Pulmonary Aspergillosis (IPA) is a relevant opportunistic disease among neutropenic patients with hematological diseases. Besides them, studies have been showing that critically ill in intensive care units (ICU), mainly those infected by respiratory virus such as SARS-CoV-2 are also at risk to be co-infected Aspergillus and developing IPA. Objectives We aimed evaluate the detection of tracheal samples from an ICU on...
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 Fungus collection is an essential approach to allow future studies, including molecular, and epidemiological characteristics, virulence factors, susceptibility profile, others. Ideal methods should keep the isolates viable for long periods of storage. The mineral oil method theoretically a secure efficient storage filamentous dimorphic fungi, Sporothrix spp., periods. Objective We aimed evaluate recovery rate spp. maintained...
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 Sporotrichosis due to Sporothrix brasiliensis is an emerging and neglected disease in Brazil. Domestic cats are susceptible a severe presentation of this mycosis, carrying high fungal load their lesions. They frequently infect other animals even humans by scratches and/or bites. Thus, the correct management treatment feline sporotrichosis crucial aspects control population. Objective We aimed evaluate outcome cases hyperendemic...