A5019112879- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
Grenoble Institute of Neurosciences
2021-2023
Inserm
2021-2023
Université Grenoble Alpes
2021-2023
Centre Hospitalier Universitaire de Grenoble
2021
Abstract Cajal-Retzius cells (CRs) are transient neurons, disappearing almost completely in the postnatal neocortex by programmed cell death (PCD), with a percentage surviving up to adulthood hippocampus. Here, we evaluate CR’s role establishment of adult neuronal and cognitive function using mouse model preventing Bax-dependent PCD. CRs abnormal survival resulted impairment hippocampus-dependent memory, associated vivo attenuated theta oscillations enhanced gamma activity dorsal CA1. At...
Abstract The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of use disorder, remain elusive. key modulator motivational processes, dopamine (DA), is suspected to play an important role in this pathology, but its exact remains be determined. Here, we found that rats expressing compulsive-like operationalized as punishment-resistant self-administration, showed decrease DA levels restricted the dorsolateral territories striatum, main output structure...
Abstract The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of use disorder, remain elusive. key modulator motivational processes dopamine (DA) is suspected to play an important role in this pathology, but its exact implication remains be determined. Here, we found that rats expressing alcohol-related behavior, operationalized as punishment-resistant self-administration, showed decrease DA levels restricted the dorsolateral territories striatum, main output...