A5066614331- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cell death mechanisms and regulation
- COVID-19 and healthcare impacts
- Enhanced Recovery After Surgery
- Cardiac Fibrosis and Remodeling
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Anesthesia and Pain Management
- Endometrial and Cervical Cancer Treatments
- Nanoparticle-Based Drug Delivery
- Head and Neck Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical Cancer and HPV Research
- Toxin Mechanisms and Immunotoxins
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Intestinal and Peritoneal Adhesions
- Chemical Reactions and Isotopes
- Congenital Diaphragmatic Hernia Studies
- CAR-T cell therapy research
- Soft tissue tumors and treatment
- Tracheal and airway disorders
University of Kentucky
2024
Nanjing University of Chinese Medicine
2024
Markey Cancer Center
2024
Centre Hospitalier Régional et Universitaire de Nancy
2024
Hôpital Nord
2024
Thomas Jefferson University
2021-2022
Thomas Jefferson University Hospital
2020-2021
Royal Prince Alfred Hospital
2011-2021
Community Link
2021
Cooper University Health Care
2020
Significance Myocardial infarction (MI) remains a leading cause of mortality and morbidity worldwide. Although it is recognized that balanced timely terminated proinflammatory response following acute MI essential in promoting tissue repair/regeneration, the underlying regulatory mechanisms are poorly defined. In this report, we show IL-10–producing B cells mice: 1) Are enriched pericardial adipose tissues (PATs) influenced by cytokines preferentially expressed these tissues; 2) expand PATs...
The objective of this study was to assess the efficacy an enhanced recovery after surgery (ERAS) protocol and determine its effect on racial/ethnic disparities in postcesarean pain management.We performed institutional review board-approved retrospective cohort scheduled cesarean deliveries before ERAS implementation at a single urban academic institution. Pre-ERAS, all analgesic medications were given postoperatively patient request. included preoperative acetaminophen celecoxib....
OBJECTIVE: To describe the clinical characteristics of transmasculine individuals who underwent hysterectomy and characterize surgical pathology findings. METHODS: Under an institutional review board-approved protocol, were undergoing bilateral salpingectomy or salpingo-oophorectomy retrospectively identified from a single institution. Past medical, surgical, obstetric, gynecologic history collected, including prior testosterone use, cervical cancer screening status, preoperative pelvic...
Artesunate belongs to a class of medications derived from the sweet wormwood plant (Artemisia annua) known as artemisinins. has traditionally been used frontline treatment for severe malaria but also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In current study, we investigated ability navitoclax, an inhibitor antiapoptotic Bcl-2 protein family, enhance...
Extrapleural pneumonectomy (EPP) has been established as a viable surgical option in the treatment of malignant pleural mesothelioma (MPM) for selected patients. A number pathological staging systems have developed to prognosticate survival outcomes. We assessed 91 patients with MPM who underwent EPP our institution and evaluated applicability most updated current literature. After mean follow-up 20 months, median overall was 27.6 months. Postoperative according International Mesothelioma...
Uterine smooth muscle tumors are the most common of female genital tract and include leiomyoma (LM) its variants, uncertain malignant potential (STUMP), leiomyosarcoma (LMS). Accurate diagnosis LMS is determined by nuclear atypia, mitotic count, presence or absence tumor cell necrosis, a process which often difficult subjective. In this study, we correlated digital quantification proliferation marker Ki-67 phosphohistone H3 (PHH3) to classification uterine tumors, clinical outcomes. A total...
Background . Human papilloma viruses (HPVs) cause a variety of clinical manifestations in children including skin warts, laryngeal papillomas, and condyloma acuminatum. Whereas the mode transmission is well understood management HPV infection clearly defined by guidelines adults, less known about transmission, natural history disease, appropriate high-risk anogenital infections children. Case The patient previously healthy 6-year-old female who presented with multiple vaginal lesions causing...
Abstract Ovarian cancer is the deadliest gynecologic in United States, and new treatment strategies are needed. We have developed M1 (anticancer) derived engineered vesicles (MEVs) which able to both deliver chemotherapy re-polarize tumor associated macrophages (TAMs) an or anticancer phenotype. 34 mouse xenografts were generated with CAOV-3 luciferase expressing ovarian cells that injected intraperitoneally into BALB/c scid mice. Mice randomized 4 groups, control, empty MEVs (E-MEVs),...
Abstract Objectives: Paclitaxel is a commonly used chemotherapy agent for women with recurrent ovarian cancer; however, its efficacy limited by the development of ABCB1-mediated drug resistance. Lapatinib an EGFR and HER2 inhibitor approved treating breast cancer but without single activity in cancer. also ABCB1 inhibitor, we hypothesize that lapatinib overcomes paclitaxel resistance previously treated patients. Methods: This phase 1 dose escalation study Bayesian optimal interval (BOIN)...
Abstract Acute myocardial infarction (MI) provokes an inflammatory response in the heart that removes damaged tissues to facilitate repair. However, exaggerated and/or persistent inflammation compromises healing, which may be counteracted by regulatory immune mechanisms. A key factor is anti-inflammatory cytokine IL-10, can produced a number of cells including subsets B lymphocytes. Here, we investigated IL-10-producing pericardial adipose (PATs) and their role healing process following...