A5033408607- Escherichia coli research studies
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Bacterial Genetics and Biotechnology
- Hydrogen's biological and therapeutic effects
- Autophagy in Disease and Therapy
- Vibrio bacteria research studies
- NF-κB Signaling Pathways
- Clostridium difficile and Clostridium perfringens research
- Medical and Biological Ozone Research
- Cancer Research and Treatments
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Toxoplasma gondii Research Studies
- Laser Applications in Dentistry and Medicine
- interferon and immune responses
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Salmonella and Campylobacter epidemiology
- Immunotherapy and Immune Responses
Tokyo Medical and Dental University
2018-2024
The University of Tokyo
2007-2023
Chiba University Hospital
2016-2023
Chiba University
2020
Kumamoto University
2019
Tokyo University of Science
2006-2016
Biology of Infection
2012-2014
National Institute of Infectious Diseases
2007-2011
Nara Institute of Science and Technology
2011
Suzuki (Japan)
2007
Shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but precise mechanisms this remain poorly understood. We demonstrate here that IL-1beta processing induced by are mediated through Ipaf, a cytosolic pattern-recognition receptor nucleotide-binding oligomerization domain (NOD)-like (NLR) family, adaptor protein apoptosis-associated speck-like containing C-terminal caspase recruitment (ASC). also show Ipaf was critical for...
Significance Shigella modulates macrophage cell death by activating nucleotide-binding oligomerization domain–like receptor (NLR) inflammasome to secure its own dissemination. Here we report that invasion plasmid antigen H7.8 (IpaH7.8) plays a central role in inducing via activation of NLR family pyrin domain-containing 3 and CARD 4 inflammasomes an IpaH7.8 enzyme (E3) ligase-dependent manner. Importantly, IpaH7.8-deficient mutant was unable egress from macrophages efficiently, resulting...
The intricate interplay between gut microbes and the onset of experimental autoimmune encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable similarities CD4+ T cells in spinal cord their counterparts small intestine. Furthermore, unveil a synergistic relationship microbiota, particularly enriched with tryptophan metabolism gene EC:1.13.11.11, intestinal cells. This symbiotic collaboration results biosynthesis kynurenic acid (KYNA), which modulates recruitment...
Abstract Increases in adhesive and invasive commensal bacteria, such as Escherichia coli , subsequent disruption of the epithelial barrier is implicated pathogenesis inflammatory bowel disease (IBD). However, protective systems against are not fully understood. Here, we show that secretion luminal glycoprotein 2 (GP2) from pancreatic acinar cells induced a TNF–dependent manner mice with chemically colitis. Fecal GP2 concentration also increased Crohn’s diease patients. Furthermore,...
Shigella possess 220 kb plasmid, and the major virulence determinants, called effectors, type III secretion system (TTSS) are exclusively encoded by plasmid. The genome sequences of S. flexneri strains indicate that several ipaH family genes located on both plasmid chromosome, but whether their chromosomal IpaH cognates can be secreted from remains unknown. Here we report strain, YSH6000 encodes seven cognate chromosome proteins via TTSS. kinetics bacteria, however, showed delay compared...
NF-κB plays a central role in modulating innate immune responses to bacterial infections. Therefore, many pathogens deploy multiple mechanisms counteract activation. The invasion of and subsequent replication Shigella within epithelial cells is recognized by various pathogen recognition receptors as pathogen-associated molecular patterns. These trigger defense via the activation signaling pathway. Here, we show inhibition delivery IpaH E3 ubiquitin ligase family member IpaH0722 using...
Article13 July 2020Open Access Source DataTransparent process A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8 Hiroshi Ashida Corresponding Author [email protected] orcid.org/0000-0003-1408-6864 Department Bacterial Infection and Host Response, Graduate School Medical Dental Sciences, Tokyo University (TMDU), Tokyo, Japan Mycology Research Center, Chiba University, Chiba, Search for more papers this author Chihiro Sasakawa...
Abstract Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. However, mechanisms by which bacteria adapt to environment are poorly understood. Here, we show that a small non-coding RNA H. (HPnc4160, also known as IsoB or NikS) regulates pathogen’s adaptation host well bacterial oncoprotein production. In rodent model infection, genomes isolated from possess an increased number T-repeats upstream HPnc4160-coding region, and this leads reduced HPnc4160...