A5084992280- Neonatal Respiratory Health Research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- COVID-19 Impact on Reproduction
- Pregnancy-related medical research
- Neonatal and Maternal Infections
- Fetal and Pediatric Neurological Disorders
- Autopsy Techniques and Outcomes
- Nutritional Studies and Diet
- Parvovirus B19 Infection Studies
- Folate and B Vitamins Research
- Simulation-Based Education in Healthcare
- Global Maternal and Child Health
- Reproductive tract infections research
- Smoking Behavior and Cessation
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Risks and Factors
University of Puget Sound
2025
Swedish Medical Center
2014-2024
Swedish Medical Center
2015-2021
Seattle Reproductive Medicine
2021
University of Washington
2011-2020
University of California, Irvine Medical Center
2017
Fred Hutch Cancer Center
2015
Oregon Health & Science University
2008-2010
Aaron Diamond AIDS Research Center
2002-2003
Rockefeller University
2002-2003
The impact of coronavirus disease 2019 on pregnant women is incompletely understood, but early data from case series suggest a variable course illness asymptomatic or mild to maternal death. It unclear whether manifest enhanced similar influenza viral infection specific risk factors might predispose severe disease.To describe and obstetrical outcomes associated with in pregnancy rapidly inform clinical care.This retrospective study patients laboratory-confirmed acute respiratory syndrome 2 6...
Sixteen subjects were treated with highly active antiretroviral therapy within 120 days of the onset symptoms newly acquired human immunodeficiency virus type 1 (HIV-1) infection. Eleven 16 participated in an adjunctive therapeutic vaccine trial. After a mean 3.2 years treatment, they elected to discontinue therapy. Virus rebound occurred all and was followed by spontaneous, transient although significant reduction log plasma HIV-1 RNA level, ranging from 0.3 3.1 log(10) copies/mL. Despite...
Objective To assess temporal changes in prevalence of transmitted HIV-1 drug resistance a homogeneous cohort newly infected individuals. Methods Pretreatment genotypic and phenotypic was tested 154 subjects with primary infection identified between 1995 2001 (group A; n = 76) 1999 B; 78). Sequence analysis assessed by population-based sequencing. Virus susceptibility to antiretroviral agents determined the PhenoSense assay (ViroLogic). Results The frequency resistance-associated mutations...
In Brief OBJECTIVE: To investigate the risk of uterine rupture in women with prior periviable cesarean delivery and term independent initial incision type. METHODS: We conducted a retrospective longitudinal cohort study using Washington state birth certificate data hospital discharge records, identifying primary deliveries performed at 20–26 weeks 37–41 gestation subsequent between 1989 2008. compared two groups considering both type labor induction augmentation. RESULTS: identified 456...
This study evaluated whether intensification of standard antiretroviral therapy with abacavir, or without efavirenz, leads to better viral suppression and acceleration the rate HIV-1 decay. Ten HIV-1–infected individuals were enrolled in a prospective, open-label received standard, combination either 3 4 agents. The decay latent reservoir frequency intermittent viremia compared between 5 patients who underwent treatment control subjects comparable baseline characteristics. When patients,...
Objective: Prompt recognition and response to postpartum hemorrhage (PPH) are vital in preventing maternal morbidity mortality. We conducted a multi-center study evaluate situ simulation team training for PPH among experienced clinical teams non-academic hospitals urban rural communities.
Early events leading to intrauterine infection remain poorly defined, but may hold the key preventing preterm delivery. To determine molecular pathways within fetal membranes (chorioamnion) associated with early choriodecidual that progress premature rupture of (PPROM), we examined effects a Group B Streptococcus (GBS) on chorioamnion in nonhuman primate model. Ten chronically catheterized pregnant monkeys (Macaca nemestrina) at 118–125 days gestation (term = 172 days) received inoculation...
Background/Objectives: It is challenging to obtain all the required views for a fetal anatomy ultrasound examination, so exams are often incomplete. Our objective was develop and demonstrate quantitative methods assess overall rate of incomplete an practice individual examiners. Methods: We performed retrospective quality review detailed at 7 maternal-fetal medicine practices in 2024 with singleton pregnancies cardiac activity present. Exams were considered if any 36 reported as inadequate....
Background/Objectives: It is challenging to obtain all the required views for a fetal anatomy ultrasound examination, so exams are often incomplete. Our objective was develop and demonstrate quantitative methods assess overall rate of incomplete an practice individual examiners. Methods: We performed retrospective quality review detailed at seven maternal–fetal medicine practices in 2024 with singleton pregnancies cardiac activity present. The were considered if any 36 reported as...
The emergence of antiretroviral (ARV) drug-resistant human immunodeficiency virus type 1 (HIV-1) quasispecies is a major cause treatment failure. These variants are usually replaced by drug-sensitive ones when the selective pressure drugs removed, as former have reduced fitness in drug-free environment. This was rationale for design structured ARV interruption (STI) studies management HIV-1 patients with We studied origin emerging after STI failure due to drug resistance. Plasma and...
Intrauterine exposure to amniotic fluid (AF) cytokines is thought predispose bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS on RNA expression in fetal lung tissue determine early molecular pathways associated with injury that may progress BPD.
ABSTRACT It is believed that replication capacity an important determinant of human immunodeficiency virus type 1 (HIV-1) pathogenicity and transmissibility. To explore this, we conducted a comprehensive analysis the properties nine drug-resistant drug-susceptible viral isolates derived from patients with primary HIV-1 infection. Viral were tested for single-cycle infectivity in GHOST cell line. The carrying resistance-associated mutations was significantly higher than isolates....
The mechanisms underlying fetal lung injury remain poorly defined. MicroRNAs (miRNAs) are small noncoding, endogenous RNAs that regulate gene expression and have been implicated in the pathogenesis of disease. Using a nonhuman primate model choriodecidual infection, we sought to determine if differentially expressed miRNAs were associated with acute injury. After inoculating 10 chronically catheterized pregnant monkeys (Macaca nemestrina) either group B streptococcus (GBS) at 1 × 10(6) CFU...
Abstract Background Infection-induced preterm birth is a major cause of neonatal mortality and morbidity leads to premature rupture placental chorioamniotic membranes. The loss amniotic epithelial cells tensile strength preceding membrane poorly understood. We hypothesized that intrauterine bacterial infection induces changes in microRNA (miRNA) expression, leading cell weakening. Methods Ten pregnant pigtail macaques received choriodecidual inoculation either group B Streptococcus (GBS) or...
( Am J Obstet Gynecol . 2016;215(2):223.e1–223.e6) Data from ultrasound scans and hospital records were examined for patients who gave birth years 2000 to 2012. Patients with a diagnosis of vasa previa or suspected considered inclusion in the study. Only whom operative, delivery and/or pathology report specifically described met criteria confirmed diagnosis. Among 68 pregnancies, 49 them have previa, either based on operative both; 47 cases (96%) diagnosed by antenatal scanning, 2 (4%)...
Objective To evaluate the test performance of a novel sequencing technology using molecular inversion probes applied to cell-free DNA screening for fetal aneuploidy. Methods Two cohorts were included in evaluation; risk-based cohort women receiving diagnostic testing first and second trimesters was combined with stored samples from pregnancies fetuses known be aneuploid or euploid. All blinded personnel before being analyzed, validation occurred after study closed results merged. Results...
Background: Intrauterine exposure to amniotic fluid (AF) cytokines is thought predispose bronchopulmonary dysplasia (BPD).We evaluated the effects of GBS on RNA expression in fetal lung tissue determine early molecular pathways associated with injury that may progress BPD. Methods:Ten chronically catheterized pregnant monkeys (Macaca nemestrina) at 118-125 days gestation (term = 172 days) received choriodecidual inoculation either: 1) Group B Streptococcus (n 5) or 2) saline 5).Cesarean...