A5007317564- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Reproductive System and Pregnancy
- Global Maternal and Child Health
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Preterm Birth and Chorioamnionitis
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
- Influenza Virus Research Studies
- Birth, Development, and Health
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Diabetes Management and Research
- Advanced Proteomics Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Immune responses and vaccinations
- Prenatal Screening and Diagnostics
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Syphilis Diagnosis and Treatment
- COVID-19 and healthcare impacts
University of Washington
2016-2025
University of Washington Medical Center
2020-2024
Seattle University
2019-2021
University of Malawi
2015
Emory University
2011-2013
The impact of coronavirus disease 2019 on pregnant women is incompletely understood, but early data from case series suggest a variable course illness asymptomatic or mild to maternal death. It unclear whether manifest enhanced similar influenza viral infection specific risk factors might predispose severe disease.To describe and obstetrical outcomes associated with in pregnancy rapidly inform clinical care.This retrospective study patients laboratory-confirmed acute respiratory syndrome 2 6...
OBJECTIVE: To describe preterm birth frequency and newborn infant outcomes overall among children in the MATISSE (Maternal Immunization Study for Safety Efficacy) trial of maternal vaccination with bivalent respiratory syncytial virus (RSV) prefusion F protein–based vaccine (RSVpreF) to protect infants against severe RSV-associated illness. METHODS: was a global, phase 3, randomized, double-blind trial. Pregnant individuals received single injections RSVpreF or placebo. Adverse events...
Vaccines against SARS-CoV-2 are highly effective in preventing COVID-19 illness. 1,2Research has found that is associated with adverse events pregnancy, 3 and recommendations therefore include offering vaccines to pregnant lactating individuals, despite their lack of inclusion initial clinical trials. 4,5To date, limited data on vaccine pregnancy outcomes exist for lactation. 6The objective this study was investigate experiences individuals after receiving vaccines. MethodsIn January 2021,...
Importance COVID-19 vaccine–derived antibodies in pregnant people may protect infants from severe infection the first 6 months of life via transplacental antibody transfer. Few data exist on maternally derived SARS-CoV-2 preterm compared with full-term association vaccination timing. Objective To compare anti-Spike (anti-S) levels and context vaccine dose timing before delivery. Design, Setting, Participants This prospective cohort study enrolled individuals collected paired maternal cord...
We found low prevalence of SARS-CoV-2 (2.7% [5/188]) among pregnant and postpartum patients with universal testing. Prevalence symptomatic was similar under initial targeted screening (22.2% [4/18]) approaches (19.1% [8/42]). Among 170 asymptomatic patients, 2 were positive or inconclusive, respectively; repeat testing at 24 hours negative.
<h3>Importance</h3> COVID-19 vaccine boosters or third doses are recommended for adolescents and adults who completed their initial course more than 5 months prior. Minimal data available on booster dose reactogenicity among pregnant lactating individuals. <h3>Objective</h3> To describe the reactions to of experiences <h3>Design, Setting, Participants</h3> Beginning in October 2021, a follow-up Research Electronic Data Capture (REDCap) survey regarding was sent 17 504 participants an ongoing...
Background: Multivalent conjugate Group B streptococcus (GBS) vaccines are in development for use pregnancy. We aimed to understand perceptions of a novel GBS vaccine among pregnant and lactating persons following the COVID experience. Methods: As part an ongoing survey-based prospective cohort study, we conducted follow-up survey with questions about knowledge acceptability clinical trial participation vaccine. Participants this Institutional Review Board-exempt study completed surveys via...
We analyzed paired maternal and cord samples for anti-spike protein antibody levels from pregnant individuals who received at least 2 doses of an mRNA COVID-19 vaccine before delivery had diagnoses consistent with placental dysfunction including pre-eclampsia and/or small-for-gestational-age infants. Our findings reveal similar median across all groups despite the presence these pregnancy complications.
Background: The maternal immunization platform has multiple vaccines already being utilized with more considered. Methods: We describe areas knowledge gaps regarding including (1) pathogen, (2) vaccine product, (3) strategy, (4) implementation research and (5) Regulatory Public Health Policy. Results: Despite advances in clinical during pregnancy, many questions remain administration, products, coadministration of acceptance. Issues antibody transfer high-risk pregnancies need further study....
BACKGROUND: Safe and effective vaccines are a key preventative measure to protect infants from SARS-CoV-2 infection disease. Although mRNA induce robust antibody titers in infants, little is known about the quality of CD4 T-cell responses induced by vaccination. important orchestrating coordinated immune during may help limit disease severity. METHODS: To characterize response vaccination we sampled blood 13 before after primary vaccine series; samples 12 historical vaccinated adults were...
Introduction The "percentage of births attended by a skilled birth attendant" (SBA) is an indicator that has been adopted several global monitoring frameworks, including the Sustainable Development Goal (SDG) agenda for regular as part target 3.1 reducing maternal mortality 2030. However, accurate and consistent measurement challenged contextual differences between within countries on definition SBA, education, training, competencies, functions they are qualified to perform. This scoping...
Abstract Background Respiratory syncytial virus (RSV)–associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (&lt;2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies LBW infants. We aimed evaluate naturally acquired RSV anti–prefusion F protein (anti-preF) antibody pregnancies with versus normal (NBW) Methods In this cohort study conducted among...
As perinatally HIV-infected (PHIV) women reach reproductive age, there is an increasing number who become pregnant. This a retrospective cohort study of delivered from June 2007 to July 2012 at our institution. Maternal demographics, HIV characteristics, and obstetric neonatal outcomes were compared. 20 PHIV 80 SHIV pregnancies reviewed. The groups had similar CD4+ counts, prevalence AIDS, use antiretrovirals (ARV) initiation obstetrical care. significantly more likely be younger, have...