A5073943337- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Neurobiology and Insect Physiology Research
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Insect Utilization and Effects
- SARS-CoV-2 and COVID-19 Research
- LGBTQ Health, Identity, and Policy
- Sex and Gender in Healthcare
- COVID-19 Impact on Reproduction
- Electrochemical sensors and biosensors
- Adipose Tissue and Metabolism
University of Washington
2020-2023
Abstract The effects of two different mitochondrial‐targeted drugs, SS‐31 and NMN, were tested on Old mouse hearts. After treatment with the individually or Combined, heart function was examined by echocardiography. partially reversed an age‐related decline in diastolic while NMN fully deficiency systolic at a higher workload. Metabolomic analysis revealed that both Combined increased nicotinamide 1‐methylnicotinamide levels, indicating greater NAD + turnover, but only resulted significantly...
Abstract Sex has a major effect on the metabolome. However, we do not yet understand degree to which these quantitative sex differences in metabolism are associated with anatomical dimorphism and modulated by sex-specific tissues. In fruit fly, Drosophila melanogaster , knocking out doublesex ( dsx ) gene gives rise adults intermediate characteristics. Here sought determine this key node sexual development leads fly We measured 91 metabolites across head, thorax abdomen comparing between...
Sweetwyne, Mariya T.; Coig, Rene; Mangalindan, Ruby Sue M.; Morton, John; Whitson, Jeremy A.; Rabinovitch, Peter S.; Ladiges, Warren C. Author Information