A5073501558- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- interferon and immune responses
- Echinoderm biology and ecology
- Virus-based gene therapy research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Insect and Arachnid Ecology and Behavior
- Parasite Biology and Host Interactions
- Immune Response and Inflammation
- Insect and Pesticide Research
- Viral Infections and Immunology Research
- Malaria Research and Control
- Herpesvirus Infections and Treatments
- Galectins and Cancer Biology
- Insect symbiosis and bacterial influences
- Plant and animal studies
- Parasites and Host Interactions
- Plant-Microbe Interactions and Immunity
- Marine Biology and Environmental Chemistry
- Endoplasmic Reticulum Stress and Disease
Center for Cancer Research
2018-2024
National Cancer Institute
2018-2024
National Institutes of Health
2021
Cancer Institute (WIA)
2021
George Washington University
2010-2018
University of New Mexico
2008
SummaryFrom studies of behaviour, chemical communication, genomics and developmental biology, among many others, honey bees have long been a key organism for fundamental breakthroughs in biology. With genome sequence hand, much improved genetic tools, are now an even more appealing target answering the major questions evolutionary population structure, social organization. At same time, agricultural incentives to understand how fall prey disease, or evade survive their pests pathogens,...
S-acylation, also known as palmitoylation, is the most widely prevalent form of protein lipidation, whereby long-chain fatty acids get attached to cysteine residues facing cytosol. In humans, 23 members zDHHC family integral membrane enzymes catalyze this modification. S-acylation critical for life cycle many enveloped viruses. The Spike SARS-CoV-2, causative agent COVID-19, has cysteine-rich cytoplasmic tail among human pathogens in closely related β-coronaviruses; however, it unclear which...
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry also serve as targets for host adaptive immune response. In this study, we investigate mechanism action MARCH family cellular proteins disrupt trafficking virion incorporation viral across several families.
Guanylate-binding protein (GBP) 5 is an interferon-inducible cellular factor with broad anti-viral activity. Recently, GBP5 has been shown to antagonize the glycoproteins of a number enveloped viruses, in part by disrupting host enzyme furin. Here we show that strongly impairs infectivity virus particles bearing not only viral depend on furin cleavage for infectivity-the envelope (Env) HIV-1 and murine leukemia spike (S) glycoprotein severe acute respiratory syndrome coronavirus 2...
The purple sea urchin, Strongylocentrotus purpuratus, possesses a sophisticated innate immune system that functions without adaptive capabilities and responds to pathogens effectively by expressing the highly diverse SpTransformer gene family (formerly Sp185/333 family). swift expression response sequence diversity of cDNAs suggest encoded proteins have functions. Individual urchins can express up 260 distinct their suggests different versions may Although deduced are diverse, they share an...
The purple sea urchin, Strongylocentrotus purpuratus, has a complex and robust immune system that is mediated by number of multi-gene families including the SpTransformer (SpTrf) gene family (formerly Sp185/333). In response to challenge from bacteria various pathogen-associated molecular patterns, SpTrf genes are up-regulated in urchin phagocytes express diverse array proteins. We show here proteins coelomocytes isolated nickel affinity (cNi-SpTrf) bind Gram-positive Gram-negative Baker's...
The purple sea urchin, Strongylocentrotus purpuratus, expresses a diverse immune response protein family called Sp185/333. A recombinant Sp185/333 protein, previously rSp0032, shows multitasking antipathogen binding ability, suggesting that the mediates flexible and effective to multiple foreign cells. Bioinformatic analysis predicts rSp0032 is intrinsically disordered, its characteristic suggests structural flexibility adopt different conformations depending on characteristics of target. To...
An emerging class of cellular inhibitory proteins has been identified that targets viral glycoproteins. These include the membrane-associated RING-CH (MARCH) family E3 ubiquitin ligases that, among other functions, downregulate cell-surface involved in adaptive immunity. The domain MARCH is thought to function by catalyzing ubiquitination cytoplasmic tails (CTs) target proteins, leading their degradation. have recently reported retroviral envelope glycoproteins (Env) and vesicular stomatitis...
The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety roles in the downregulation cell-surface proteins involved adaptive immunity. RING-CH domain is thought ubiquitinate cytoplasmic tails (CTs) target proteins, leading protein degradation through either lysosomal or proteasomal pathways. Three (MARCH1, 2, and 8) recently HIV-1 envelope glycoprotein (Env) vesicular stomatitis virus G (VSV-G), thereby impairing infectivity virions...