A5079856305- Radiology practices and education
- Medical Malpractice and Liability Issues
- Radiation Dose and Imaging
- Patient Safety and Medication Errors
- Geriatric Care and Nursing Homes
- Corneal surgery and disorders
- Nutrition and Health in Aging
- Frailty in Older Adults
- Emergency and Acute Care Studies
- Ophthalmology and Visual Impairment Studies
- Cardiac Health and Mental Health
- Health Policy Implementation Science
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Nursing Roles and Practices
- Global Health Workforce Issues
- Glaucoma and retinal disorders
- Alzheimer's disease research and treatments
- Nursing education and management
- Electronic Health Records Systems
- Respiratory viral infections research
- Physiological and biochemical adaptations
- Influenza Virus Research Studies
- Intraocular Surgery and Lenses
Flinders University
2021-2025
The University of Adelaide
2013-2023
Flinders Medical Centre
2021-2023
National Health and Medical Research Council
2017-2023
University Hospitals of the Ruhr-University of Bochum
2018-2021
Ruhr University Bochum
2019-2021
Israel National Institute for Health Policy Research
2020-2021
Israel Ministry of Health
2020-2021
Thomas College
2019
Janssen (United States)
2013-2018
Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K<sup>+</sup> channels are critically involved in modulating calcium-signaling cascades membrane potential both excitable nonexcitable cells. Activators of these constitute useful pharmacological tools new drugs for the treatment ataxia, epilepsy, hypertension. Here, we used neuroprotectant riluzole as a template design KCa2/3 channel activators that potent enough vivo studies. Of library 41...
Objective: To evaluate the effectiveness of implementation a TeamSTEPPS (Team Strategies and Tools to Enhance Performance Patient Safety) program at an Australian mental health facility. Design, setting participants: is evidence-based teamwork training system developed in United States. Five care sites South Australia implemented using train-the-trainer model over 8-month intervention period commencing January 2008 concluding September 2008. A team senior clinical staff was formed each site...
The appropriate handover of patients, whereby responsibility and accountability care is transferred between healthcare providers, a critical component quality delivery. This paper examines data from recent incidents relating to clinical in acute settings, order provide basis for the design implementation preventive corrective strategies. A sample (n = 459) was extracted an Australian health service's incident reporting system using manual search function. Incident narratives were subjected...
Retracting published scientific articles is increasingly common. Retraction a self‐correction mechanism of the community to maintain and safeguard integrity literature. However, retracted article may pose profound long‐lasting threat credibility New unknowingly build their work on false claims made in articles. Such dependencies become implicit indirect. Consequently, it becomes important detect indirect threats. In this article, our aim raise awareness potential threats even after...
Hypothetical models of AD progression typically relate clinical stages to sequential changes in CSF biomarkers, imaging, and cognition. However, quantifying the continuous trajectories proposed by these over time is difficult because
Abstract Background Rapid frailty screening remains problematic in primary care. The diagnostic test accuracy (DTA) of several instruments has not been sufficiently established. We evaluated the DTA against two reference standards: Fried’s Frailty Phenotype [FP] and Adelaide Index [AFI]), a self-reported questionnaire. Methods study within three general practices South Australia. randomly recruited 243 practice patients aged 75+ years. Eligible participants were years, proficient English...
Purpose: To compare the visual acuity and satisfaction outcomes of 2 different concepts extended depth-of-focus intraocular lenses (EDOF IOLs). Setting: University Eye Hospital Bochum, Germany. Design: Prospective randomized comparative clinical trial. Methods: Patients undergoing cataract surgery with implantation concept EDOF IOLs. In first group (IC-8 Group), a monofocal 1-piece Tecnis Z B00 IOL (Johnson & Johnson Vision Care, Inc.) was implanted in dominant eye, an IC-8 (AcuFocus)...
Background: The six-item cognitive impairment test (6CIT) is a brief screening tool that can be administered to older people in 2–3 min.Objective: To adapt the 6CIT for European Portuguese and determine its psychometric properties based on sample recruited from several contexts (nursing homes; universities people; day centres; primary health care units).Method: original was translated into draft version (6CIT-P) back-translated piloted. accuracy of 6CIT-P assessed by comparison with...
Abstract Introduction The dynamic range of cerebrospinal fluid (CSF) amyloid β (Aβ 1–42 ) measurement does not parallel to cognitive changes in Alzheimer's disease (AD) and cognitively normal (CN) subjects across different studies. Therefore, identifying novel proteins characterize symptomatic AD samples is important. Methods Proteins were profiled using a multianalyte platform by Rules Based Medicine (MAP‐RBM). Due underlying heterogeneity unbalanced sample size, we combined (344 325 CN)...
PURPOSE: To compare the clinical outcomes with extended depth of focus small-aperture intraocular lens (IOL) (IC-8; AcuFocus, Irvine, CA) for presbyopia compensation when implanted monocularly or binocularly. METHODS: Visual outcomes, defocus curve, patient satisfaction, and visual symptoms during a 6-month follow-up were evaluated in 11 patients (contralateral group) this IOL an aspheric monofocal fellow eye (myopic target) 6 (bilateral bilaterally IC-8 (dominant plano target, myopic...
This umbrella review aimed to examine and synthesize qualitative studies that explored the barriers facilitators of advance care planning for persons with dementia, their families, healthcare professionals caregivers. The modified approach developed by Joanna Briggs Institute was followed. Five major English databases were searched. Four reviews based on 38 primary included. methodological quality included moderate high. synthesis yielded 16 descriptive themes five analytical themes: making...
AbstractIn a double-blind, randomized, multicenter trial in 80 consecutive outpatients with endoscopically verified duodenal ulcer, we have tested the ulcer-healing efficacy of quite low dose antacids, given only four times daily. The patients received one chewable aluminum-magnesium-antacid tablet (buffering capacity, 30 mmol/tablet) or placebo 1 h after meals and at bedtime. Re-endoscopy 4 weeks treatment showed healed ulcer 28 38 (74%) antacid group, compared 11 (29%) group (p < 0.001)....
The objective is to develop a semi-mechanistic disease progression model for mild cognitive impairment (MCI) subjects. aims describe the longitudinal of ADAS-cog scores from Alzheimer's neuroimaging initiative trial that had data 198 MCI subjects with cerebrospinal fluid (CSF) information who were followed 3 years.Various covariates tested on parameters and these variables fell into six categories: imaging volumetrics, biochemical, genetic, demographic, tests CSF biomarkers.CSF biomarkers...
The health of reintroduced animals has received little attention despite the potential impacts poor animal on overall success reintroduction and risks to host environment. As part a program, captive-bred brush-tailed rock-wallabies (BTRWs) (Petrogale penicillata) were hardened-off for at least three months before release into Grampians National Park, western Victoria. A total 41 involved in project, with 24 selected hardening-off aged between 1.1 4.3 years. In all, 21 have been released,...
To determine the type and nature of incidents occurring within medical imaging settings in Australia identify strategies that could be engaged to reduce risk their re-occurrence.71 search terms, related clinical handover communication, were applied 3976 Radiology Events Register. Detailed classification thematic analysis a subset involved or communication (n=298) undertaken most prevalent types error make recommendations about patient safety initiatives imaging.Incidents occurred frequently...