A5020988091- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Healthcare Systems and Public Health
- Adipokines, Inflammation, and Metabolic Diseases
- Human Health and Disease
- Nutrition, Genetics, and Disease
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Galectins and Cancer Biology
- Apelin-related biomedical research
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Diet, Metabolism, and Disease
- GDF15 and Related Biomarkers
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Genetic Associations and Epidemiology
- Biomarkers in Disease Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipid metabolism and biosynthesis
- Paraoxonase enzyme and polymorphisms
- Demographic Trends and Gender Preferences
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
First Pavlov State Medical University of St. Petersburg
2010-2025
Federal Almazov North-West Medical Research Centre
2011-2024
Southern Federal University
2023
University of Jyväskylä
2017
Vitebsk State Medical University
2015
Saint Petersburg State Pediatric Medical University
2010
Abstract The population of Russia consists more than 150 local ethnicities. ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the uniquely positioned investigate shared properties inherited disease risks between European Asian ancestries. We present analysis genetic phenotypic data a cohort 4,145 individuals collected in three metro areas western Russia. show presence multiple admixed ancestry clusters spanning primarily high identity-by-descent sharing...
To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype potential genetic traits associated a benign metabolic status.503 AO without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose serum insulin levels, HOMA-IR, lipid profile, adiponectin (AN) leptin (LEP) concentrations in measured. Polymorphisms A19G Q223R the LEP receptor gene, G276T T45G AN gene investigated.91.3%...
Abstract The population of Russia consists more than 150 local ethnicities. ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the uniquely positioned investigate shared properties inherited disease risks between European Asian We present analysis genetic phenotypic data a cohort 4,145 individuals collected in three metro areas western Russia. show presence multiple admixed ancestry clusters spanning primarily high identity-by-descent sharing with Finnish...
To search for the association between vitamin D status and anxiety depression.Authors examined 310 residents of St. Petersburg (137 men 173 women). Anxiety depression were measured with HADS.In people deficiency, noted in 32.5% 11.0%, respectively. There negative correlations serum 25(OH)D level (r= -0,11, p=0.03). Symptoms not correlated -0.08, p=0.09) but age (r=0.12, p=0.02). After excluding other risk factors psychogenic disturbances (obesity, hypertension impaired glucose metabolism) we...
Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well the most important transcriptional regulators adipogenesis - LXRa, LXRb, PPARg RORa has been investigated in intraabdominal adipose tissue (IAT) samples.A direct correlation between content proteins with protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests role transcription factor regulation IAT levels. gene positively correlated obesity indicators such body mass index (BMI)...
At the end of 20th century, contribution hyperlipoproteinemia (a) to early development and severity coronary, cerebral peripheral artery atherosclerosis was established, its association with aortic valve stenosis shown. The results epidemiological studies allow us consider lipoprotein(a) (Lp(a)) as a new target for diagnosis, prevention pharmacotherapy atherosclerotic cardiovascular diseases. atherogenicity Lp(a) is 6 times higher than that low-density lipoproteins can be cause rapid...
Aim . To determine the blood level of inflammatory markers, parameters characterizing obesity and cardiac remodeling in patients with atrial fibrillation (AF) combination metabolic syndrome (MS). Material methods This single-stage case-control study included 677 subjects aged 35 to 65 years: MS (n=407), which 128 AF; comparison group — AF without (n=75); control practically healthy cardiovascular diseases disorders (n=195). Results It was found that concentration circulating pro-inflammatory...
Background. Imidazoline receptor agonist moxonidine besides its antihypertensive effect, can increase insulin sensitivity, reduce leptin level, improve lipid metabolism. However, the efficacy, tolerability and pleiotropic effects of in postmenopausal women with essential hypertension (EH) metabolic syndrome (MS) are not well established, it was objective this study. Design methods. 30 EH MS (52,5 ± 0,4 years old) were included. Moxonidine administered (400-600 mkg/day) for 12 weeks. Waist...
Adiponectin levels, lipid profile and parameters of glucose metabolism were evaluated in patients with abdominal obesity. It was found that adiponectin level negatively correlated body mass index (BMI). The significant correlations between levels adiponectin, triglycerides, high-density lipoprotein (HDL) cholesterol Patients obesity arterial hypertension had higher total cholesterol, low-density (LDL) triglycerides comparing to non-hypertensive BMI increase positively insulin resistance...
Aim. To study the levels of galectin 3 and aldostrone in blood serum metabolic syndrome (MS) patients atrial fibrillation (AF) for their importance evaluation. Material methods. Totally 100 with MS (IDF, 2005) studied, those 50 AF: 28 paroxysmal 22 persistent types. Controls were almost healthy persons without cardiovascular pathology disorders. Levels aldosterone measured by ELISA. All participants also underwent anthropometry, lipid profile fasting glycemia measurements, transthoracal...
Objective: to investigate influence of different forms adiponectin on carotid intima-media thickness (CIMT) in women with abdominal obesity (AO) St.-Petersburg. It has been recognized before that AO is associated cardiovascular diseases, including atherosclerosis, but mechanism this association remains unclear. leads imbalance adipokines, particularly decrease adiponectin, which may lead atherosclerotic lesion arteries. Materials and methods. We investigated 81 (IDF criteria, 2005) 21 normal...
Objective. The activity of renin-angiotensin-aldosterone system (RAAS) is increased in patients with ab-dominal obesity (AO). However, till present time it unclear whether RAAS activation or hypertension (HTN) found 50 % the primary disorder. Design and methods. We have studied plasma renin (PRA), aldosterone concentration (PAC), their ratio PAC/PRA AO related HTN subjects without AO. Results. PRA was higher versus people (2,5 ± 0,2 1,7 0,7 ng/ml/hr, p = 0,013), there a tendency to reduction...
Objective: To assess the prevalence and forms of metabolic syndrome in patients with abdominal obesity population St Petersburg according to criteria International Diabetic Federation (IDF, 2005) European Cardiology Society (ESH ESC, 2007). Design methods. 966 employees, aged 30-55 years, were examined. Waist circumference, weight, body mass index (BMI), height, blood pressure measured. The levels total cholesterol, triglycerides (TG), low- high- density cholesterol (LDL-C HDL-C), glucose...
Objective. To assess the relationship of carriers risk alleles for rs9939609 polymorphisms FTO gene and rs1225537 TCF7L2 with metabolic syndrome (MS) component in a national population sample three regions (Samara, Orenburg, St Petersburg) as part ESSE-RF epidemiological study. Design methods . The data 3 were analyzed: Samara, Orenburg Petersburg. total number patients included study was 4 793 people, average age examined 45,6 ± 11,9 years. All participants underwent an assessment...
The objective of this work was to study the character lipid oxidation during physical exercises different intensity and identify factors influencing process in patients with abdominal obesity. included 90 aged from 30 55 years obesity (AO). Lipid (LO) (PE) measured by indirect colorimetric technique assessment oxygen consumption (VO2peak), anaerobic threshold (AT), respiratory coefficient (RQ). level activity (PA) body composition were determined. Patients exhibited maximum at low-intensity...
Objective. T o evaluate diastolic function of the left ventricle and anthropometric parameters in patients with abdominal obesity (AO). Design methods . We examined 438 aged 30 to 55 years (44,8 ± 0,3 years) AO (IDF, 2005) 115 (40,3 0,8 without (comparison group). Two-dimensional transthoracic echocardiography was performed (GE Vivid 7 Dimension) 2D mode, M-mode, also Doppler studies were using pulsed, continuous-wave, color tissue regimes Doppler. Results. Based on echocardiography, 126...
Актуальность. Адипонектин (АН) - протективный адипоцитокин, продуцируемый жировой тканью и циркулирующий в крови виде различных изомеров. При абдоминальном ожирении (АО) сниженная концентрация АН ассоциируется с развитием метаболи- ческого синдрома (МС), его отдельных компонентов сердечно-сосудистых заболеваний. кодируется геном ADIPOQ . Показано, что генетические варианты ассоциированы изменением концентрации сыворотки крови.Цель исследования. Выявить ассоциации полиморфных вариантов...