A5101996213- Mesenchymal stem cell research
- TGF-β signaling in diseases
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Catalytic C–H Functionalization Methods
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Osteoarthritis Treatment and Mechanisms
- Immune cells in cancer
- Digestive system and related health
- Clinical Nutrition and Gastroenterology
- S100 Proteins and Annexins
- Wnt/β-catenin signaling in development and cancer
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Histone Deacetylase Inhibitors Research
- Urinary Bladder and Prostate Research
- Radical Photochemical Reactions
- Medical Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Wound Healing and Treatments
Yonsei University
2011-2023
Severance Hospital
2019-2022
Ewha Womans University
2022
Dunsan Korean Medicine Hospital
2018
Eulji University
2016
Emerging evidence indicates that the activity of pyruvate kinase M2 (PKM2) isoform is crucial for survival tumor cells. However, molecular mechanism underlying function PKM2 in renal cancer undetermined. Here, we reveal overexpression proximal tubule tissues from 70 cases patients with carcinoma. The functional role human cells following small-interfering RNA-mediated knockdown, which retarded 786-O cell growth was examined. Targeting affected protein B (AKT)/mechanistic target rapamycin 1...
Paracrine factors secreted by mesenchymal stem cells (MSCs) reportedly modulate inflammation and reparative processes in damaged tissues have been explored for knee osteoarthritis (OA) therapy. Although various studies reported the effects of paracrine OA, it is not yet clear which directly affect regeneration cartilage are under OA conditions. In this study, we cultured MSCs derived from three types treated each type with IL-1β TNF-α or to obtain conditioned medium. Each medium was used...
Fibrosis development in ulcerative colitis is associated directly with the severity of mucosal inflammation, which increases risk colorectal cancer. The transforming growth factor-β (TGF-β) signaling pathway an important source tissue fibrogenesis, stimulated by reactive oxygen species produced from nicotinamide adenine dinucleotide phosphate oxidases (NOX). Among members NOX family, NOX4 expression up-regulated patients fibrostenotic Crohn's disease (CD) and dextran sulfate sodium...
Double or quits? double hydroacylation reactions of acyclic and cyclic α,β-unsaturated aldehydes with olefins afford ketone diketone products, respectively. Enantiomers are formed whose absolute configurations controlled by the order alkene addition.
Dovitinib (TKI258) is a small molecule multi-kinase inhibitor currently in clinical phase I/II/III development for the treatment of various types cancers. This drug has safe and effective pharmacokinetic/pharmacodynamic profile. Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. Herein, we investigated effect on human recombinant bone morphogenetic protein (BMP)-2-induced differentiation cell...
Macrophages are highly heterogeneous immune cells with a role in maintaining tissue homeostasis, especially activating the defense response to bacterial infection. Using flow cytometric and single-cell RNA-sequencing analyses of peritoneal cells, we here show that small macrophage immature populations enriched histamine-deficient ( Hdc -/- ) mice, characterized by CD11b mi F4/80 lo CCR2 + MHCII hi THBS1 IL-1α phenotype, respectively. Molecular characterization revealed macrophages represent...
Objective This study is designed to evaluate the effects of Korean medicine treatment for facial nerve palsy. Method The patient was administered treatment, including acupuncture, pharmacopuncture, and herbal medicine. We used House-Brackmann Grading System Yanagiharaâs Unweighted assess symptoms Results patientâs grade reduced from IV II, increased 19 32. symptoms, which were pain, asymmetry, wrinkling forehead, incomplete closing eye, epiphora, tinnitus, improved during...
Abstract The title reaction of acyclic α,β‐unsaturated aldehydes with alkenes leads to two ketone products via 1,4‐addition a primary amine (CyNH 2 or hexylamine) the aldehyde followed by retro‐Mannich‐type fragmentation resulting β‐aminoketimine intermediates.
Objective: Overactive bladder syndrome refers to the symptom of frequent urination, as function is so sensitive that muscles contract regardless patientâs intent and patient feels need urinate quickly. common among elderly, especially in women, prevalence increases with increasing age. can decrease social activity, increase isolation, quality life due sleep disorders caused by night urination; therefore, active treatment required. In this study, we report effects Korean medical on a...