A5102761919- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Infection Control and Ventilation
- Metalloenzymes and iron-sulfur proteins
- Refrigeration and Air Conditioning Technologies
- Peptidase Inhibition and Analysis
- Trace Elements in Health
Vellore Institute of Technology University
2024
Centre for DNA Fingerprinting and Diagnostics
2014-2015
Manipal Academy of Higher Education
2015
Iron is an essential nutrient for all living organisms and human pathogens employ a battery of factors to scavenge iron from the high-affinity iron-binding host proteins. In present study, we have elucidated, via candidate gene approach, major acquisition homoeostatic mechanisms operational in opportunistic fungal pathogen Candida glabrata. Phenotypic, biochemical molecular analysis set 13 C. glabrata strains, deleted proteins potentially implicated metabolism, revealed that reductive uptake...
Candida glabrata has emerged as a major fungal pathogen over the last two decades, although our understanding of its survival strategies inside mammalian host remains rudimentary. An important requirement for in vivo is ability to acquire critical nutrients such iron from niches varied content. In present study, we demonstrate first time that C. cells respond high external levels via activation stress-responsive mitogen-activated protein kinases, CgHog1 and CgSlt2, lack either kinase results...
Antifungal therapy failure can be associated with increased resistance to the employed antifungal agents. Candida glabrata, second most common cause of invasive candidiasis, is intrinsically less susceptible azole class antifungals and accounts for 15% all bloodstream infections. Here, we show that C. glabrata MED2 (CgMED2), which codes a tail subunit RNA polymerase II Mediator complex, required drugs in glabrata. An inability transcriptionally activate genes encoding zinc finger...