A5006094084- Pain Management and Treatment
- Neurological disorders and treatments
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Vagus Nerve Stimulation Research
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Spine and Intervertebral Disc Pathology
- Cardiovascular Syncope and Autonomic Disorders
- Pain Mechanisms and Treatments
- Menopause: Health Impacts and Treatments
- Neonatal and fetal brain pathology
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Motor Control and Adaptation
- Infrared Thermography in Medicine
- Advanced Neuroimaging Techniques and Applications
- Fatty Acid Research and Health
- Cardiac, Anesthesia and Surgical Outcomes
Florida Atlantic University
2023-2025
University of Arizona
2024
Albany Medical Center Hospital
2019-2022
University of Houston
2014-2018
Middle East Technical University
2013
Spinal cord stimulation (SCS) is a well-accepted therapy for refractory chronic pain. However, predicting responders remain challenge due to lack of objective pain biomarkers. The present study applies machine learning predict which patients will respond SCS based on intraoperative electroencephalogram (EEG) data and recognized outcome measures. included 20 who were undergoing surgery. During monitoring, EEG signals recorded under OFF (baseline) ON conditions, including tonic high density...
Optimal electrophysiological placement of the DBS electrode may lead to better long term clinical outcomes. Inter-subject anatomical variability and limitations in stereotaxic neuroimaging increase complexity physiological mapping performed operating room. Microelectrode single unit neuronal recording remains most common intraoperative technique, but requires significant expertise is fraught by potential technical difficulties including robust measurement signal. In contrast, local field...
Significance Despite the fact that deep-brain stimulation (DBS) of subthalamic nucleus (STN) has emerged as an effective surgical treatment for Parkinson’s disease (PD), there is no available neurobiomarker providing information about symptoms PD subtypes in STN. In this paper, we report finding neural correlates two motor phenotypes territories advances imaging, microelectrode recording continues to be best practice and dominant method STN localization during DBS surgery [Abosch A, et al....
Sleep is a fundamental homeostatic process, and disorders of sleep can greatly affect quality life. Parkinson’s disease (PD) highly comorbid for spectrum deep brain stimulation (DBS) the subthalamic nucleus (STN) has been reported to improve architecture in PD. We studied local field potential (LFP) recordings PD subjects undergoing STN-DBS over course full-night’s sleep. examined changes oscillatory activity recorded from STN between ultradian states determine whether sleep-stage dependent...
Background: Deep brain stimulation (DBS) is an emerging treatment strategy for severe, medication-refractory Tourette syndrome (TS). Thalamic (Cm-Pf) and pallidal (including globus pallidus interna, GPi) targets have been the most investigated. While neurophysiological correlates of Parkinson's disease (PD) in GPi subthalamic nucleus (STN) are increasingly recognized, these patterns not well characterized other states. Recent findings indicate that cross-frequency coupling (CFC) between beta...
INTRODUCTION: Chronic pain is a debilitating condition that impacts over 17 million people around the world. While spinal cord stimulation (SCS) promising therapy, patient selection remains challenging due to an inability predict who will experience relief. METHODS: Patients were scheduled for permanent SCS implant surgery their chronic back and/or leg recruited study. Pain outcome data (e.g., Numeric Rating Scale, Catastrophizing Scale) collected preoperatively and 3 months after surgery....
Directional deep brain stimulation (DBS) technology aims to address the limitations, such as stimulation-induced side effects, by delivering selective, focal modulation via segmented contacts. However, DBS programming becomes more complex and time-consuming for clinical feasibility. Local field potentials (LFPs) might serve a functional role in guiding programming.In this pilot study, we investigated spectral dynamics of directional LFPs subthalamic nucleus (STN) their relationship motor...
Background: The efficacy of deep brain stimulation (DBS) therapy in Parkinson's disease (PD) patients is highly dependent on the precise localization target structures such as subthalamic nucleus (STN). Most commonly, microelectrode single unit activity (SUA) recordings are performed to refine target. This process heavily experience-based and can be technically challenging. Local field potentials (LFPs), representing a population neurons, obtained from same microelectrodes used for SUA allow...
Despite spinal cord stimulation's (SCS) proven efficacy, failure rates are high with no clear understanding of which patients benefit long term. Currently, patient selection for SCS is based on the subjective experience implanting physician.To develop machine learning (ML)-based predictive models long-term response.A combined unsupervised (clustering) and supervised (classification) ML technique was applied a prospectively collected cohort 151 patients, included 31 features. Clusters...
Ethanol is known as a potent teratogen having adverse effects on brain and behavior. However, some of the behavioral deficits caused by fetal alcohol exposure well expressed in juveniles ameliorate with maturation may suggest kind functional recovery occurring during postnatal development. The aim this study was to reexamine age-dependent impairments fetal-alcohol rats investigate changes neurogenesis gross morphology hippocampus protracted period searching for developmental and/or delays...
Abstract BACKGROUND Models have been developed for predicting ideal contact and amplitude subthalamic nucleus (STN) deep brain stimulation (DBS) Parkinson disease (PD). Pulse-width is generally varied to modulate the size of energy field produced. Effects varying frequency in humans not systematically evaluated. OBJECTIVE To examine how altered frequencies affect blood oxygen level-dependent activation PD. METHODS PD subjects with optimized DBS programming underwent functional magnetic...
Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms Parkinson's disease. However, precise intraoperative localization STN remains procedural challenge. In present study, local field potentials (LFPs) were recorded from DBS macroelectrodes during trajectory to STN, in six patients. The frequency-vs-depth map LFP activity was extracted and further analyzed within different sub-bands, investigate whether can be used border identification....
BACKGROUND AND OBJECTIVES: As spinal cord stimulation (SCS) offers a therapy for increasing numbers of patients with chronic pain and injury, it becomes increasingly important to better understand its somatotopy. In this prospective study, we investigate whether high-resolution SCS (HR-SCS) improved selectivity assessed through elicitation evoked electromyography (EMG) responses as compared commercial paddle leads. METHODS: Vertical tripole configurations were used elicit EMG in both types...
Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms Parkinson's disease. However, precise intraoperative localization STN remains procedural challenge. In present study, local field potentials (LFPs) were recorded from three tracks during microelectrode recording-based (MER) targeting STN, in five patients. The raw LFP data preprocessed original recording setup and then quality was compared to with common average derivation....
BACKGROUND: High-resolution spinal cord stimulation (HR-SCS) paddle can stimulate medial-dorsal columns and extend coverage to the laterally positioned targets. OBJECTIVE: To investigate medio-lateral selectivity of an HR-SCS in patients with chronic pain. METHODS: During standard-of-care (SCS) placement, epidurally evoked electromyography antidromic dorsal column–evoked potentials were recorded 12 subjects using 8 sites spanning full epidural width at thoracic T9-12 a commercial...
Intraoperative neurophysiological monitoring (IONM) in spinal cord stimulation (SCS) surgery for chronic pain is shown to provide effective guidance during device placement. Electromyography (EMG) used determine the laterality of paddle. In some SCS cases, cannot be obtained via EMG due patient physiology. Electroencephalography (EEG) already IONM monitor cortical responses. Here, we show proof-of-concept assessing responses epidurally evoked EMGs simultaneously with EEGs using a...
Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor optimal targeting the relevant structures. Computational models can help interpret patient's by predicting volume tissue activated (VTA) around electrode contacts. Here we report results preliminary study in two patients with obsessive-compulsive disorder show that VTA predictions, which are based on patient-specific conductor models, correlate...
Aim: Effects of age and sex on chronic pain outcomes following spinal cord stimulation (SCS) have not yet been assessed. Methods: We retrospectively reviewed 1 year from a database patients receiving thoracic SCS. Subjects were divided into four cohorts: pre-menopausal post-menopausal females, aged-matched males. Improvement using the numerical rating scale, Oswestry Disability Index (ODI), Beck's Depression Inventory (BDI), McGill Pain Questionnaire Catastrophizing Scale (PCS) was Results:...
INTRODUCTION: Chronic pain is a prevalent issue that may affect up to 34% of US adults, and spinal cord stimulation (SCS) promising therapy. However, SCS device selection remains challenge because there are currently no objective biomarkers evaluate chronic pain, or predict which patients will be responders. METHODS: Intraoperative EEG signals were recorded in 24 (14 women) during permanent electrode placement surgery. Neural responses captured with respect tonic (60 Hz/300 µs)...