A5026853056- Invertebrate Immune Response Mechanisms
- Silk-based biomaterials and applications
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Insect Resistance and Genetics
- Cancer Immunotherapy and Biomarkers
- Plant Molecular Biology Research
- Neurobiology and Insect Physiology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
Southwest Hospital
2023
Army Medical University
2023
Southwest University
2016-2020
State Key Laboratory of Silkworm Genomic Biology
2017-2020
Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To explore the underlying regulators, we examine microenvironment in glioma and find that tumor-infiltrating T cells mainly confined perivascular cuffs express high levels of CCR5, CXCR3, programmed cell death protein 1 (PD-1). Combined analysis clustering with receptor (TCR) clone expansion shows potential tumor-killing categorized into pre-exhausted/exhausted effector CD8+ subsets, as well cytotoxic CD4+...
Atlastin is a member of the dynamin protein superfamily and it can mediate homotypic fusion endoplasmic reticulum (ER) membranes, which required for many biological processes. In this study, new homologous protein, BmAtlastin-n, was characterized in silkworms found to contain an N-terminal conserved GTPase domain coiled-coil middle domain. BmAtlastin-n localized cytoplasm enriched silkworm midgut. Results also showed that overexpression BmN-SWU1 cells could enhance resistance BmNPV. To...
Cyclin proteins are the key regulatory and activity partner of cyclin-dependent kinases (CDKs), which play pivotal roles in cell cycle progression. In present study, we identified a L1 2 CDK11 splice variants, CDK11A CDK11B, from silkworm, Bombyx mori. We determined that both CDK11A/B nuclear proteins, further investigations were conducted to elucidate their spatiofunctional features. forms complex with co-localized nucleus. Moreover, dimerization CDK11B effects on regulation also...
Ecdysteroid titer determines the state of cell cycle in silkworm (Bombyxmori) metamorphosis. However, mechanism this process is unclear. In study, we demonstrated that BmFoxO gene participates regulation induced by 20-Hydroxyecdysone (20E) BmN-SWU1 cells. The 20E blocks G2/M phase through ecdysone receptor (EcR) and inhibits DNA replication. can promote expression. Immunofluorescence Western blot results indicated induce nuclear translocation Overexpression affects progression, which arrest...