A5018667601- Inflammatory mediators and NSAID effects
- Renal Transplantation Outcomes and Treatments
- Adenosine and Purinergic Signaling
- Signaling Pathways in Disease
- Connexins and lens biology
- Liver Disease and Transplantation
- Eicosanoids and Hypertension Pharmacology
- Magnesium in Health and Disease
- Oral and gingival health research
- Pancreatic function and diabetes
- Cytomegalovirus and herpesvirus research
- Renin-Angiotensin System Studies
- Thermoregulation and physiological responses
- RNA Interference and Gene Delivery
- Organ Transplantation Techniques and Outcomes
- Forensic Entomology and Diptera Studies
- Nuclear Receptors and Signaling
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
Charité - Universitätsmedizin Berlin
2020-2021
Abstract Aim The use of calcineurin inhibitors such as cyclosporine A (CsA) for immunosuppression after solid organ transplantation is commonly limited by renal side effects. CsA‐induced deterioration glomerular filtration rate and sodium retention may be related to juxtaglomerular dysregulation a result suppressed cyclooxygenase 2 (COX‐2) stimulated renin biosynthesis. We tested whether COX‐2 suppression caused hyperactive renin‐angiotensin system (RAS) RAS inhibition alleviate the Methods...
Connexins (Cxs) form gap junctions for intercellular exchange of inorganic ions and messenger molecules. In the kidney, Cxs play essential roles within its compartments, but data on precise cellular localization cell type-related function their isoforms are scarce. We tested whether Cx43 distribution is restricted to vascular interstitial cells medullary fibroblasts express coordinate profibrotic signaling. Confocal immunofluorescence techniques, ultrastructural labeling, functional...
Objective Calcineurin inhibitors such as cyclosporin A (CsA) are in use immunosuppressive drugs to prevent rejection of transplanted organs. Despite positive outcomes, side effects decreased glomerular filtration rate and overall functional structural deterioration may affect the kidney. Among causes, interactions vasoactive systems have been considered. We therefore studied how CsA cause dysregulation key juxtagomerular signaling components. Methods Wistar rats were divided into 4 groups...
Objective Connexin 43 (Cx43) is a gap junction‐forming protein which mediates the intercellular passage of molecules < 1000 Da. In kidney, Cx43 was reported in glomerular vessels and mesangium. Own results prompted us to reevaluate distribution its phosphorylated form, phospho‐S368‐Cx43 (pCx43), within different zones rat kidney cultured fibroblasts more detail. Methods pCx43 were localized by immunofluorescence sections human fibroblasts. High‐resolution immunostaining achieved...
Demirci, Hasan; Yilmaz, Duygu E.; Popovic, Suncica; Hu, Junda; Mutig, Kerim; Bachmann, Sebastian Author Information