Fast, convenient, and highly sensitive detection of antibiotic is essential to avoid its overuse the possible harm. Owing enrichment effect antifouling ability ultrasmall nanochannels, vertically ordered mesoporous silica nanochannel film (VMSF) has great potential in development facile electrochemiluminescence (ECL) sensor for direct analysis antibiotics complex samples. In this study, we demonstrated a flexible ECL based on cost-effective electrode covered with VMSF clindamycin....

Colorectal cancer (CRC) metastasis plays a crucial role in disease progression, yet the regulatory mechanisms underlying remain incompletely understood. Isobutyric acid (IBA), short-chain fatty found at high levels serum of CRC patients, has been shown to be critical metabolite influencing proliferation. However, its tumor remains unknown. Here, utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis, we that IBA were significantly higher patients with distant organ than...

There have been more than 12 million open source software in GitHub so far, but the existing studies about sentiments analysis are not sufcient for GitHub. This paper proposes an approach to analyze correlation of comment and bug fixing speed. It's proved existence certain factors among some relevance after experiments. The experimental results also give suggestions on development process.

Process variation may lead to chip fail because of the property its datapath and clock network. We consider problem finding an optimal schedule, which has not only minimal period but also maximal tolerant process variation. Clock skew scheduling is modeled as a constraint difference system, can be solved by graph theory. The basic traditional algorithm vulnerability that value near boundary. parametric shortest path inserts unified margin in with loss circuit performance. present approach...

Yield driven skew scheduling method leads to a clock tree with much greater wire length and buffer number that is not acceptable by designer. Geometry based register position relationships are converted constraints combined timing harmoniously. With the two kinds of together, our algorithm solves problem for both restrictions gives safety margins only variations but clocktree variations. It makes yield network realizable inpractical design. Experimental results show has 72.7% improvement...

Short-term load forecasting is an important part to support the planning and operation of power grid, but current methods have problem poor adaptive ability model parameters, which are difficult ensure demand for efficient accurate grid forecasting. To solve this problem, a short-term method smart proposed based on multilayer network model. This uses integrated empirical mode decomposition (IEMD) realize orderly reliable state data provides high-quality prediction The enhanced inception...

ABSTRACT Introduction Isobutyric acid (IBA), a short‐chain fatty acid, has been unequivocally demonstrated to exert significant influence on the progression of colorectal cancer (CRC). Nevertheless, comprehensive understanding its intricate regulatory mechanisms remains elusive. Methods Employing advanced techniques such as western blot, RT‐qPCR, and flow cytometry, we systematically investigated impact IBA expression PD‐L1 in CRC cells. Concurrently, employing RNA silencing technology...

This study uses a self-developed anti-corrosion pill particle as the research object and develops population modelling method in order to optimize process of oil gas wellbore casing annuli. The shape is similar cylinder, according test analysis geometrical characteristics, can be simplified into three types based on height, namely particles A (5.4 mm), B (5.8 C (6.2 mm). multi-sphere approach then used create models different with varying degrees precision. feasibility effectiveness for...

We propose a new quick and effective buffered legitimate skew clock routing algorithm BLST. analyze the optimal buffer position in path, conclude sufficient heuristic condition for insertion net. During process, this integrates topology generation, insertion, node merge together, performs them parallel. Compared with method of X. Zheng et al. (1999) after routing, BLST improves maximal delay by at least 22%. M. Zhao (2003) no buffer, further decreases total wire length gets from 42% to 82%...

In synchronous VLSI designs, clock network quality plays a key role in determining system performance. As part of routing, the tree topology generation is crucial problem to solution. We explore characteristics trees and give simulated annealing method solving routing by manipulating topology. The elaborately designed rules generating neighbor solution at each iteration step process have an important impact on final experimental results illustrated, our approach effective for zero skew...

As the clock frequency rises rapidly, skew has acted as a more important role in synchronous circuits. In this paper, we propose new buffered tree routing algorithm to prevent influence of process variations and environmental effects skew. Based on concept BSF (Branch Sensitivity Factor), our manages reduce sensitivity topology generation. The worst case due wire width change been estimated, proper buffers are inserted avoiding large capacitance load. Experimental results show that can...

Iterative slack distribution is a prevalent method in timing analysis and clock scheduling. Finding minimum mean cycle the most time consuming step each iterative process. We present practical strategy that can speed up loop. A fast negative detection used for examining whether of length two really cycle. Traditional complicated algorithm be skipped during Experimental results show our reduce running The percentages are from 47% to 90% different benchmark circuits.

In order to handle the corrosion of underwater production pipe sinks in deepwater oil fields, a non-solid phase silicone plugging agent, an external clamp, and injection tool are combined this paper’s innovative pipeline repair technique proposal. The optimal main agent curing ratio for agents was found be 100:25, which achieved through experimental examination process. compressive cementing strength changes curd were disclosed by testing evaluating mechanical behavior agent. addition,...

Time-of-use price adjustments are becoming more and frequent, there is an urgent need to study methods evaluate the effect of time-of-use adjustments. This paper analyses electricity adjustment from two perspectives: monthly average load curve overall large industry general commerce, key industries. The assessment came completely opposite conclusions. conclusions drawn analysis deceptive through comparison. In-depth segmentation can accurately objectively effect. conclusion this has certain...

In this paper, based on abnormal load data, the method of energy Internet data detection and correction is proposed chaotic directional cuckoo algorithm (COCS) to optimize Elman-IOC prediction model. Firstly, model trained through a large amount COCS optimization selected find parameters model, parameter-tuned used prediction. And then, starting from results prediction, in curve detected by error analysis outliers determination criteria, corrected applying results.