A5089940976- Advanced Operator Algebra Research
- Advanced Topics in Algebra
- Homotopy and Cohomology in Algebraic Topology
- Endoplasmic Reticulum Stress and Disease
- Algebraic structures and combinatorial models
- Immunotherapy and Immune Responses
- Mathematical Analysis and Transform Methods
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- interferon and immune responses
- Immune Cell Function and Interaction
- Advanced Algebra and Geometry
University of Virginia
2022-2024
Centre d’Immunologie de Marseille-Luminy
2024
University of Chile
2022-2024
Some basic notions and results in topological dynamics are extended to continuous groupoid actions spaces. We focus mainly on recurrence properties. Besides that analogous the classical case of group actions, but which have be put right setting, there also new phenomena. Mostly for groupoids whose source map is not open (and many), some properties were equivalent become distinct this general framework; we illustrate with various counterexamples.
Abstract Adoptive T cell therapy (ACT) has demonstrated remarkable efficacy in treating hematological cancers. However, its against solid tumors remains limited and the emergence of cancer cells that lose expression targeted antigens often promotes resistance to ACT. Importantly, mechanisms underlying effective durable ACT-mediated tumor control are incompletely understood. Here, we show adoptive transfer TCR-transgenic CD8 + eliminates established murine melanoma tumors, with concomitant...
In this note we show that the twisted convolution algebra $L^1_{\alpha,\omega}({\sf G},\mathfrak A)$ associated to a action of locally compact group ${\sf G}$ on $C^*$-algebra $\mathfrak A$ has following property: Every quotient by closed two-sided ideal finite codimension produces semisimple algebra. We use property, together with results H. Dales and G. Willis, build up previous author produce large classes examples algebras properties automatic continuity.
ABSTRACT The unfolded protein response (UPR) is a key stress resistance pathway that has become potential target for improving the efficacy of cancer chemotherapy. UPR involves activation three ER-resident sensors: PERK, IRE-1 and ATF6 with different signalling outcomes leading to cell death or survival. These cell-fate decisions are difficult predict result complex interaction downstream events have differences in their dynamics interplay. characteristics still poorly defined due lack...
Abstract Given a Fell bundle $\mathscr C\overset {q}{\to }\Xi $ over the discrete groupoid $\Xi , we study symmetry of associated Hahn algebra $\ell ^{\infty ,1}(\Xi \!\mid \!\mathscr C)$ in terms isotropy subgroups . We prove that is symmetric (respectively hypersymmetric) if and only all are hypersymmetric). also characterise hypersymmetry using bundles with constant fibres, showing for groupoids, ‘hypersymmetry’ equals ‘rigid symmetry’.
Abstract The unfolded protein response (UPR) sensor IRE1 (inositol-requiring enzyme 1 alpha) and its target, the transcription factor XBP1s (X-box binding 1, spliced) critically regulates function of dendritic cell (DC) subtypes. However, contribution IRE1/XBP1s axis in DC subsets to initiation antitumor immunity is not entirely understood. In this work, using reporter mice we found that DCs, particular type conventional DCs (cDC1s), are major targets RNase activity melanoma tumors. Deletion...