A5063961876- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- RNA regulation and disease
- Chromosomal and Genetic Variations
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Environmental Sustainability in Business
- Diverse Aspects of Tourism Research
- Energy, Environment, Economic Growth
Fujian Polytechnic of Information Technology
2024
National Institutes of Health
2022-2023
National Institute on Aging
2022-2023
Fox Chase Cancer Center
2023
Institute on Aging
2022
Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, decreased in models DC. Herein, using telomerase reverse transcriptase null ( Tert −/− ) mice critically short telomeres, we investigated the effect NAD supplementation precursor, nicotinamide riboside (NR), on features health...
Tourism significantly influences world economies, necessitating sustainable business practices for long-term success. This study investigates the impact of tourism (ST) on economic growth (EG) using a questionnaire survey 370 participants, analyzed with SPSS. Findings show that ST positively correlates higher EG, especially when destinations emphasize responsible tourist development (TD), community involvement, and environmental conservation. Notably, conservation measures have significant...
Telomeric repeat-containing RNA (TERRA) and its formation of RNA:DNA hybrids (or TERRA R-loops), influence telomere maintenance, particularly in human cancer cells that use homologous recombination-mediated alternative lengthening telomeres. Here, we report the RNA-binding motif protein 14 (RBM14) is associated with telomeres cells. RBM14 negatively regulates expression. It also binds to inhibits it from forming R-loops at depletion has several effects, including elevated levels, telomeric...
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to phenotypes observed aging biology disorders. One candidate RAP1, telomere-associated protein also controls transcription at extratelomeric regions. To distinguish these roles, we generated knockin mouse carrying mutated Rap1 , which was incapable binding did not result eroded or DDR. Primary embryonic fibroblasts...