Exceptionally high piezoelectric and pyroelectric performances have been demonstrated in the three-dimensional interconnected microfoam based polymer nanocomposites.

Abstract Targeted delivery of nanoparticle (NP)‐based diagnostic and therapeutic agents to malignant cells tissues has exclusively relied on chemotargeting, wherein NPs are surface‐coated with ligands that specifically bind overexpressed receptors cells. Here, it is demonstrated cellular uptake can also be biased based the differential mechanical states cells, enabling mechanotargeting. Owing mechanotransduction, cell lines (HeLa HCT‐8) cultured hydrogels various stiffness directed into...

Fluid-to-solid phase transition in multicellular assembly is crucial many developmental biological processes, such as embryogenesis and morphogenesis. However, biomechanical studies this area are limited, little known about factors governing the how cell behaviors regulated. Due to different stresses present, cells could behave distinctively depending on nature of tissue. Here we report a fluid-to-solid geometrically confined assemblies. Under circular confinement, Madin-Darby canine kidney...

Using extracellular matrix control of cellular mechanics, we establish that force threshold can also mark <italic>in vitro</italic> metastatic phenotypic change and malignant transformation in HCT-8 cell colonies.

Gap closure to eliminate physical discontinuities and restore tissue integrity is a fundamental process in normal development repair of damaged tissues organs. Here, we demonstrate nonadhesive gap model which collective cell migration, large-scale actin-network fusion, purse-string contraction orchestrate the gap. Proliferative pressure drives migrating cells attach onto front at pluricellular actin ring already assembled. An actin-ring segment switching then occurs by fusion fibers from...

Abstract Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic, edge, and interfacial effects. Here we present a molecularly based thermodynamic model, integrating monolayer substrate elasticity, force-mediated focal adhesion formation, elucidate the active biochemical regulation over cellular force landscapes in epithelial monolayers, corroborated by microscopy immunofluorescence studies. The predicted extracellular...

AbstractThis article studies the axial buckling of a nanowire (NW) lying on Winkler–Pasternak substrate medium with Timoshenko beam theory. The surface effect NW is accounted for Steigmann–Ogden model. An explicit solution critical force and its associated mode are obtained analytically. influences stress effect, geometry NW, elastic foundation moduli behavior fully discussed.Keywords: effectsurface elasticitynanowirebucklingTimoshenko beamWinkler–Pasternak

At cell-matrix contacts, an elastocapillary effect arises in addition to active cell traction. The coexistence of extracellular traction and other interfacial forces at the contacts blurs their distinctive roles tissue morphogenesis, wound healing, cancer metastasis. Here, we first observe that colonies can indent soft hydrogels, forming dimples. inhibited contractility, dimples still occur but with a reduced depth. To exclude contact, inhibit contractility measure stresses...

Abstract Endothelial cells (ECs) elongate in the direction of blood flow, are stiffer, and considered atheroprotective areas vasculature where flow‐induced shear stress is high unidirectional softer, atherogenic, polygonal experiencing oscillatory multidirectional flow. To understand precise roles EC mechanics morphology uptake therapeutic nanoparticles (NPs) by atherogenic endothelium, human aortic ECs induced to adopt prescribed shapes imposed microcontact patterned adhesive islands. NP...

Abstract Reaction-diffusion models have been widely used to elucidate pattern formation in developmental biology. More recently, they also applied modeling cell fate patterning that mimic early-stage human development events utilizing geometrically confined pluripotent stem cells. However, the traditional reaction-diffusion equations could not satisfactorily explain concentric ring distributions of various types, as do yield circular patterns even for domains. In previous mathematical...

Epithelial cells can assemble into cohesive colonies and collectively interact with substrates by generating extracellular forces through focal adhesions. Recently, a molecularly based thermodynamic model, which integrates both the monolayer elasticity force-mediated adhesion formation, has been developed to elucidate regulation of cellular force landscape induced active epithelial-substrate coupling. However, how coupling strength mediate landscapes traction, displacement, distribution in...

Mechanotargeting of Atherogenic Endothelium In article number 202300137, Pouria Fattahi, Sulin Zhang, Peter J. Butler, and colleagues provide direct evidence for cell mechanics-based targeting nanoparticles (NPs) to atherogenic endothelium, a drug-delivery strategy termed, mechanotargeting. Microcontact-patterned adhesive islands induce endothelial cells adopt prescribed morphologies that mimic shear flow-induced phenotypes in vivo, resulting increases NP uptake with decreases cellular...

The ability of cells to sense and adapt curvy topographical features has been implicated in organ morphogenesis, tissue repair, tumor metastasis. However, how individual or multicellular assemblies differentiate curvatures remains elusive. Here, we reveal a curvature sensing mechanism which surface tension can selectively activate either actin integrin flows, leading bifurcating cell migration modes: focal adhesion formation that enables crawling at convex front edges cable assembly pulls...

Abstract Coordinated behaviors of epithelial cells are widely observed in tissue development such as re-epithelialization, tumor growth, and morphogenesis. In these processes, either migrate collectively or organize themselves into specific structures to serve certain purposes. this work, we study the spreading monolayer whose migrating front encloses a circular gap center. Such kind is usually used mimic wound healing process in-Virto. We model sheet layer active viscous polar fluid. With...

The coordinated behaviors of epithelial cells are widely observed in tissue development, such as re-epithelialization, tumor growth, and morphogenesis. In these processes, either migrate collectively or organize themselves into specific structures to serve certain purposes. this work, we study a spreading monolayer whose migrating front encloses circular gap the center. Such is usually used mimic wound healing process Virto. We model sheet layer active viscous polar fluid. With an...

The reaction-diffusion models have been extensively applied to explain the mechanism of pattern formations in early embryogenesis based on geometrically confined microtissues consisting human pluripotent stem cells. Recently, mechanical cues, such as cellular stresses and strains, found dictate formation cell differentiation. As a result, traditional are modified by adding mechanically related terms consider role played cues. However, these either do not activeness tissues or neglect their...

Abstract The coordinated behaviors of epithelial cells are widely observed in tissue development, such as re-epithelialization, tumor growth, and morphogenesis. In these processes, either migrate collectively or organize themselves into specific structures to serve certain purposes. this work, we study aspreading monolayer whose migrating front encloses a circular gap the center. Such is usually used mimic thewound healing process Virto. We model sheet layer active viscous polar fluid. With...