A5069522183- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Lanthanide and Transition Metal Complexes
- Low-power high-performance VLSI design
- Cardiac Imaging and Diagnostics
- Complex Systems and Time Series Analysis
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Signaling Pathways in Disease
- Experimental Learning in Engineering
- Single-cell and spatial transcriptomics
- Injection Molding Process and Properties
- Peroxisome Proliferator-Activated Receptors
- Additive Manufacturing Materials and Processes
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Financial Markets and Investment Strategies
- Additive Manufacturing and 3D Printing Technologies
- Genomics and Phylogenetic Studies
- Analog and Mixed-Signal Circuit Design
George Washington University
2024-2025
McCormick (United States)
2024
University of Washington
2023
Virginia Commonwealth University
2002-2020
Humboldt-Universität zu Berlin
2019
Lieber Institute for Brain Development
2012
Virginia Commonwealth University Medical Center
2012
Histone deacetylase 6 (HDAC6) inhibition is associated with an increased pro-inflammatory tumor microenvironment and antitumoral immune responses. Here, we show that the HDAC6 inhibitor AVS100 (SS208) had effect in SM1 melanoma CT26 colon cancer models efficacy of anti–programmed cell death protein 1 treatment, leading to complete remission response cancer. treatment tumor-infiltrating macrophages CD8 effector T cells inflammatory gene signature. Acquired immunity long-term protection were...
Prostaglandin regulation is known to play a pivotal role in tumorigenesis; however, the contributions of prostaglandin-metabolizing enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) cancer development remain poorly understood. In this study, we investigate effects HPGD on cell viability, proliferation, anchorage-independent growth, and migration triple-negative breast (TNBC), an aggressive subtype cancer. Overexpression human TNBC cells resulted both positive negative proliferation colony...
Deep sequencing has become a popular tool for novel miRNA detection but its data must be viewed carefully as the state of field is still undeveloped. Using three different programs, miRDeep (v1, 2), miRanalyzer and DSAP, we have analyzed seven sets (six biological one simulated) to provide critical evaluation programs performance. We selected these software based on their popularity overall approach toward known miRNAs using deep-sequencing data. The program comparisons suggest that, despite...
Abstract Inhibition of HDAC6 was associated with an increased proinflammatory tumor microenvironment and antitumoral response. Here, we show that a highly specific inhibitor AVS100 (SS208), blocks M2 polarization in murine human macrophages while partially affecting M1 polarization. effects were observed as blocked upregulation M2-related gene signature under polarizing conditions generation CD206+ Arg1+ macrophages. Oral administration had effect SM1 melanoma CT26 colon cancer models the...
Abstract Motivation Understanding genetic variation at the single-cell level is crucial for insights into cellular heterogeneity, clonal evolution, and gene expression regulation, but there a scarcity of tools visualizing analyzing cell-level variants. Results We introduce scSNViz, comprehensive R-based toolset visualization analysis cell-specific expressed Single Nucleotide Variants (sceSNVs) within cell-barcoded RNA-sequencing (scRNA-seq) data. ScSNViz offers 3D sceSNV capabilities...
Abstract Additive manufacturing (AM) has emerged as a crucial technology in recent decades, particularly within the aerospace industry. However, thermally cyclic nature of these processes introduces significant variations and defects microstructure, which can adversely affect final part performance hinder widespread adoption technology. Traditionally, characterization AM parts relied on conventional bulk testing methods, involve analyzing many samples to gather sufficient data for...
Heuring and Jordan define a simplified, 32-bit RISC processor instruction set architecture called the simple computer. An extended form of this is defined, gate-level logic design developed, full-custom VLSI implementation laid out in 0.5 /spl mu/m CMOS process, fabricated, tested. The flow, from ISA definition to IC testing, carried by junior- senior-level undergraduate engineering students over two consecutive semesters as part an integrated curriculum.