A5072659079- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Ubiquitin and proteasome pathways
- Microplastics and Plastic Pollution
- Signaling Pathways in Disease
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Urban Transport and Accessibility
- Cellular transport and secretion
- Asymmetric Hydrogenation and Catalysis
- Protein Structure and Dynamics
- Tuberculosis Research and Epidemiology
- COVID-19 Pandemic Impacts
- Toxic Organic Pollutants Impact
- Drug Solubulity and Delivery Systems
- Toxoplasma gondii Research Studies
- COVID-19 epidemiological studies
- ATP Synthase and ATPases Research
- interferon and immune responses
- Protein Tyrosine Phosphatases
National University of Sciences and Technology
2017-2024
International Islamic University, Islamabad
2012
Cytochrome P450 (CYP450) enzymes belong to a superfamily of heme-containing proteins that are involved in the metabolism structurally diverse endogenous and exogenous compounds. Various proof-of-concept studies indicate metabolic stability intrinsic clearance CYP450 substrates linked with respective lipophilicity (log P or log D). This necessitates normalization D) given substrate respect its (LipMetE) (log10CLint,u). Therefore, this article, LipMetE values already known CYP1A2, CYP2C9,...
Coronavirus disease 2019 (COVID-19) is an infectious characterised by symptoms that are like the common cold. The current pandemic situation in anticipation of a vaccine has posed serious threats to health and economic sectors countries worldwide. To overcome quick transmission virus, government Australia also taken drastic measures prevent its spread. These policies include international interstate travel ban, social distancing rules, lockdown, shutdown educational institutes work-from-home...
The Cytochrome P450 family of heme-containing proteins plays a major role in catalyzing phase I metabolic reactions, and the CYP3A4 subtype is responsible for metabolism many currently marketed drugs. Additionally, has an inherent affinity broad spectrum structurally diverse chemical entities, often leading to drug–drug interactions mediated by inhibition or induction enzyme. current study explores binding selected highly efficient inhibitors docking molecular dynamics (MD) simulation...
The expression of the drug efflux pump ABCB1 correlates negatively with cancer survival, making transporter an attractive target for therapeutic inhibition. In order to identify new inhibitors ABCB1, we have exploited cryo-EM structure protein develop a pharmacophore model derived from best docked conformations structurally diverse range known inhibitors. was used screen Chembridge compound library. We identified six potential distinct chemistry compared third-generation inhibitor tariquidar...
Tripartite motifs (TRIM) is a large family of E3 ubiquitin ligases that play an important role in ubiquitylation. TRIM proteins regulate wide range biological processes from cellular response to viral infection and are implicated various pathologies, Mendelian disease cancer. Although the has been identified characterized tetrapods, but knowledge about common carp other teleost species limited. The genes were analyzed for evolutionary relationships, characterization, functional annotation....
The cytochrome P450s (CYPs) play a central role in the metabolism of various endogenous and exogenous compounds including drugs. CYPs are vulnerable to inhibition induction which can lead adverse drug reactions. Therefore, insights into underlying mechanism CYP450 estimation overall CYP inhibitor properties might serve as valuable tools during early phases discovery. Herein, we present large data set inhibitors against five major metabolic (CYP1A2, CYP2C9, CYP2C19, CYP2D6 CYP3A4) for...
Breast carcinogenesis is known to be instigated by genetic and epigenetic modifications impacting multiple cellular signaling cascades, thus making its prevention treatments a challenging endeavor. However, modification, particularly DNA methylation-mediated silencing of key TSGs, hallmark cancer progression. One such tumor suppressor gene (TSG) RUNX3 (Runt-related transcription factor 3) has been new insight in breast suppressed due local promoter hypermethylation mediated methyltransferase...