A5043535417- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Renal Transplantation Outcomes and Treatments
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Hepatitis C virus research
- Optical Imaging and Spectroscopy Techniques
- Infectious Encephalopathies and Encephalitis
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Retinal Development and Disorders
- Histiocytic Disorders and Treatments
- Neurological disorders and treatments
- HIV Research and Treatment
- Ophthalmology and Visual Health Research
- Drug Transport and Resistance Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Pharmaceutical studies and practices
- Vascular Malformations and Hemangiomas
Stanford Medicine
2023-2025
Stanford University
2022-2025
Lucile Packard Children's Hospital
2025
Neurology, Inc
2020-2024
GTx (United States)
2023
In-Q-Tel
2023
Santa Clara Valley Medical Center
2023
Yale University
2017-2021
Tampa General Hospital
2014-2021
Winthrop-University Hospital
2019
Background and Purpose— After large-vessel intracranial occlusion, the fate of ischemic penumbra, ultimately final infarct volume, largely depends on tissue perfusion. In this study, we evaluated whether blood pressure reduction sustained relative hypotension during endovascular thrombectomy are associated with progression functional outcome. Methods— We identified consecutive patients occlusion stroke who underwent mechanical at 2 comprehensive centers. Intraprocedural mean arterial (MAP)...
Background and Purpose— Loss of cerebral autoregulation in the acute phase ischemic stroke leaves patients vulnerable to blood pressure (BP) changes. Effective BP management after endovascular thrombectomy may protect brain from hypoperfusion or hyperperfusion. In this observational study, we compared personalized, autoregulation-based targets static systolic thresholds. Methods— We prospectively enrolled 90 undergoing for stroke. Autoregulatory function was continuously measured by...
We aim to examine effects of collateral status and post-thrombectomy reperfusion on final infarct distribution early functional outcome in patients with anterior circulation large vessel occlusion ischemic stroke.Patients who underwent endovascular intervention were included this study. All had baseline computed tomography angiography follow-up magnetic resonance imaging. Collateral was graded according the criteria proposed by Miteff et al assessed using modified Thrombolysis Cerebral...
Background and Purpose- Optimal blood pressure (BP) management during the early stages of aneurysmal subarachnoid hemorrhage remains uncertain. Observational studies have found worse outcomes in patients with increased hemodynamic variability, suggesting BP optimization as a potential neuroprotective strategy. In this study, we calculated personalized targets at which cerebral autoregulation was best preserved. We analyzed how deviation from these limits correlates functional outcome....
This cohort study assesses the feasibility of determining personalized blood pressure targets as well association deviating from these with radiographic and clinical outcomes.
OBJECTIVE While the benefit of mechanical thrombectomy (MT) for patients with anterior circulation acute ischemic stroke large-vessel occlusion (AIS-LVO) has been clearly established, difficult vascular access may make intervention impossible or unduly prolonged. In this study, authors evaluated safety as well radiographic and functional outcomes in treated MT via direct carotid puncture (DCP) prohibitive access. METHODS The retrospectively studied from their prospective AIS-LVO database who...
Elevated blood pressure after endovascular thrombectomy (EVT) has been associated with an increased risk of hemorrhagic transformation and poor functional outcomes. However, the optimal hemodynamic management EVT remains unknown, course in acute phase ischemic stroke not well characterized. This study aimed to identify patient subgroups distinct trajectories their association radiographic
A healthy ex-full term 2-month-old male infant with unremarkable birth history presented frequent upbeat jerk nystagmus (Video 1).He did not reliably track or blink to threat and showed no response optokinetic drum.The remainder of the neuro-ophthalmological examination, including fundoscopy, was normal.Upbeat may localize brainstem and/or cerebellar vermis, but brain MRI normal.Complete blood count, metabolic profile, vitamin B12, B1, toxicology were normal.Trio exome sequencing revealed a...
Seizures are a recognized complication of critical cardiovascular illness in infants and children. We assessed the diagnostic yield continuous video-electroencephalography (cEEG) pediatric neonatal intensive care unit (CVICU) by symptoms risk factors prompting cEEG evaluation.
Background: Nonmydriatic ocular fundus photography has been studied with demonstrated benefit in the evaluation of emergency department neurological complaints, particularly triaging headache and focal deficits. Likewise, portable camera usage may be practical for inpatients although feasibility not a neurology teaching service. Purpose: The objective this study is to determine if portable, nonmydriatic could integrated into routine clinical care by inpatient housestaff at tertiary medical...
Acute necrotizing encephalopathy (ANE) is a rare, fulminant associated with viral infections, such as influenza, characterized by multifocal symmetric brain lesions and cytokine-mediated neuroinflammation. A 6-year-old previously healthy female, fully vaccinated except for the seasonal influenza vaccine, presented fever, sore throat, cough, worsening altered mental status. Neurological examination revealed Glasgow Coma Scale (GCS) of 6, abnormal brainstem reflexes, subsequent seizure...
This case report and discussion pertain to a 17-year-old female patient with developmental delay acute onset of psychosis, diagnosed guanidinoacetate methyltransferase (GAMT) deficiency, rare creatine biosynthesis disorder. The experienced auditory hallucinations, paranoia, delusional misidentification syndromes (Capgras syndrome reduplicative paramnesia), following viral respiratory illness. neurologic examination was nonfocal but included intermittent negative myoclonus, generalized stiff...
Introduction: Stuttering is a speech disorder in which the flow of disrupted by repetitions, prolongation, and blocks sounds, syllables, or words. No pharmacological treatments are approved for use stuttering, most common form treatment therapy. This study was designed to assess safety, tolerability, effectiveness pagoclone during 8 weeks double-blind followed 1-year open-label extension patients who stutter. Methods: An 8-week, multicenter, parallel-group, 2-arm, randomized (ratio 2:1...
The use of allografts from hepatitis C virus (HCV) Nucleic Acid Testing (NAT)+ donors into HCV NAT- recipients has been reported to be efficacious in a handful studies. However, these studies have not reflected real-world practice where the initiation direct-acting antivirals (DAA) is dependent on insurance coverage. A single-center, retrospective chart review who underwent solid organ transplantation (SOT) NAT+ donor between April 1, 2019 and May 27, 2020 was conducted. Sixty-one patients...