A5091430861- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Marriage and Sexual Relationships
- Antifungal resistance and susceptibility
- Pharmaceutical and Antibiotic Environmental Impacts
- Microscopic Colitis
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Vitamin C and Antioxidants Research
- Galaxies: Formation, Evolution, Phenomena
- Microbial Natural Products and Biosynthesis
- Bacterial biofilms and quorum sensing
- Herpesvirus Infections and Treatments
- Mycobacterium research and diagnosis
- Infection Control in Healthcare
- Cytomegalovirus and herpesvirus research
- Patient Satisfaction in Healthcare
Northeast Ohio Medical University
2014-2023
Willamette University
2011-2023
Akron General Medical Center
2013-2022
Cleveland Clinic
2015-2022
University of North Carolina at Chapel Hill
2017
Wilson Community College
2016-2017
University of Akron
2015
Biology of Infection
2015
University Hospitals Cleveland Medical Center
2014
University Hospitals Sussex NHS Foundation Trust
2005-2014
The efficacy of ceftazidime-avibactam—a cephalosporin–β-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase–producing carbapenem-resistant Enterobacteriaceae (CRE)—compared colistin remains unknown. Patients initially treated either ceftazidime-avibactam or for CRE infections were selected from the Consortium on Resistance Against Carbapenems and other (CRACKLE), a prospective, multicenter, observational study. Efficacy, safety, benefit-risk...
Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of has led to resistance this cationic antimicrobial peptide.
We present an estimate of the bulk flow in a volume radii $150-200h^{-1}$Mpc using minimum variance (MV) method with data from CosmicFlows-4 (CF4) catalog. The addition new CF4 has resulted increase sphere radius $150h^{-1}$Mpc relative to CosmicFlows-3 (CF3). This less than $0.03\%$ chance occurring Standard Cosmological Model ($\Lambda$CDM) cosmic microwave background derived parameters. Given that is deeper CF3, we were able use accurately on scales $200h^{-1}$Mpc (equivalent 266 Mpc for...
OBJECTIVE To determine the effectiveness of a pulsed xenon ultraviolet (PX-UV) disinfection device for reduction in recovery healthcare-associated pathogens. SETTING Two acute-care hospitals. METHODS We examined PX-UV killing Clostridium difficile spores, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) on glass carriers evaluated impact pathogen concentration, distance from device, organic load, shading direct field radiation efficacy. compared...
Abstract Background Predicting mortality risk in patients is important research settings. The Pitt bacteremia score (PBS) commonly used as a predictor of early with bloodstream infections (BSIs). We determined whether the PBS predicts 14-day inpatient nonbacteremia carbapenem-resistant Enterobacteriaceae (CRE) infections. Methods Patients were selected from Consortium on Resistance Against Carbapenems Klebsiella and Other Enterobacteriaceae, prospective, multicenter, observational study....
Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Many biosynthetic enzymes for RiPPs, especially thiopeptides, promiscuous can accept wide range substrates with different amino acid sequences; thus, these have been used as tools to generate new product derivatives. Here, we explore an alternative route molecular complexity by engineering thiopeptide tailoring do or non-native chemistry. We cytochrome P450...
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA), including community-associated and hospital-associated strains, is a major cause of human morbidity mortality. Treatment options have become limited due to the emergence MRSA strains with decreased sensitivity vancomycin, which has long been first-line therapy for serious infections. This prompted search novel antibiotics that are efficacious against MRSA. Linezolid, an oxazolidinone class antibiotic, was approved by Food Drug...
The increasing incidence and prevalence of multidrug resistance (MDR) among contemporary Gram-negative bacteria represents a significant threat to human health. Since their discovery, β-lactam antibiotics are major component the armamentarium against these serious pathogens. Unfortunately, wide range β-lactamase enzymes have emerged that capable inactivating powerful drugs. In past 30 years, advancement in battle microbes has been development inhibitors, which restore efficacy (e.g.,...
Early administration of appropriate empiric antibiotics is essential for achieving the best possible outcomes in sepsis. Yet choice antibiotic therapy has become more challenging due to recent reports nephrotoxicity with combination vancomycin and piperacillin/tazobactam, "workhorse" regimen at many institutions. In this article we assess evidence its mechanisms, provide recommendations risk mitigation, address advantages disadvantages alternative choices, suggest areas future research.
OBJECTIVE To determine the impact of an environmental disinfection intervention on incidence healthcare-associated Clostridium difficile infection (CDI). DESIGN A multicenter randomized trial. SETTING In total,16 acute-care hospitals in northeastern Ohio participated study. INTERVENTION We conducted a 12-month trial to compare standard cleaning enhanced that included monitoring services (EVS) personnel performance with feedback EVS and control staff. assessed thoroughness based fluorescent...