A5009843292- Mosquito-borne diseases and control
- Disaster Response and Management
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- Pharmacological Effects of Natural Compounds
- Hepatitis B Virus Studies
- Travel-related health issues
- Botulinum Toxin and Related Neurological Disorders
- HIV/AIDS Research and Interventions
- Pain Mechanisms and Treatments
- Malaria Research and Control
- Viral Infections and Vectors
Temple University
2023
Tulane University
2019-2023
Background Lassa virus (LASV), the cause of acute viral hemorrhagic illness fever (LF), is endemic in West Africa. Infections humans occur mainly after exposure to infected excrement or urine rodent-host, Mastomys natalensis . The prevalence LASV Sierra Leone crudely estimated and largely unknown. This cross-sectional study aimed establish a baseline point seroprevalence IgG antibodies three administrative districts identify potential risk factors for seropositivity exposure. Methodology...
Situated in southeastern Sierra Leone, Kenema Government Hospital (KGH) maintains one of the world's only Lassa fever isolation wards and was a strategic Ebola virus disease (EVD) treatment facility during 2014 EVD outbreak. Since 2006, Viral Hemorrhagic Fever Consortium (VHFC) has carried out research activities at KGH, capturing clinical laboratory data for suspected cases fever. Here we describe approach, progress, challenges designing maintaining capture management system (DCMS) KGH to...
Abstract A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models infection fail to recapitulate viral CNS without encephalitis or employ viruses that authentically represent ongoing HIV-1 pandemic. Here, we demonstrate replication brain and neuropathogenesis after combination antiretroviral therapy (ART) rhesus macaques (RMs) using novel macrophage-tropic transmitted/founder (TF) simian-human...