A5035149699- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Plant responses to water stress
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Coastal wetland ecosystem dynamics
- Legume Nitrogen Fixing Symbiosis
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Plant Water Relations and Carbon Dynamics
- Ammonia Synthesis and Nitrogen Reduction
- Heart Failure Treatment and Management
- Pancreatic function and diabetes
- Dialysis and Renal Disease Management
- Genomics and Phylogenetic Studies
- Acute Kidney Injury Research
- Plant Disease Resistance and Genetics
- Flood Risk Assessment and Management
- Light effects on plants
- Rice Cultivation and Yield Improvement
University of California, Riverside
2012-2025
Plant (United States)
2012-2023
Thomas Jefferson University Hospital
2022
Utrecht University
2009-2015
Centre for BioSystems Genomics
2009
Significance Flooding due to extreme weather events can be highly detrimental plant development and yield. Speedy recovery following stress removal is an important determinant of tolerance, yet mechanisms regulating this remain largely uncharacterized. We identified a regulatory network in Arabidopsis thaliana that controls water loss senescence influence from prolonged submergence. Targeted control the molecular facilitating here could potentially improve performance crops flood-prone areas.
Abstract Regulation of gene expression through translational control is common in many organisms. The Arabidopsis (Arabidopsis thaliana) transcription factor bZIP11 repressed response to sucrose (Suc), resulting Suc-regulated changes amino acid metabolism. 5′ leader the mRNA harbors several upstream open reading frames (uORFs), which second uORF well conserved among homologous genes. uORF2 element encodes a Suc peptide (SC-peptide) 28 residues that sufficient for imposing Suc-induced...
Abstract In Arabidopsis , a large subset of heat responsive genes exhibits diurnal or circadian oscillations. However, to what extent the dimension time and/or clock contribute stress responses remains largely unknown. To determine direct contribution day differential responses, we probed wild-type and mutants CCA1 LHY PRR7 PRR9 following exposure (37 °C) moderate cold (10 in early morning (ZT1) afternoon (ZT6). Thousands were differentially expressed response temperature, day, mutation....
Abstract Flooded plants experience impaired gas diffusion underwater, leading to oxygen deprivation (hypoxia). The volatile plant hormone ethylene is rapidly trapped in submerged cells and instrumental for enhanced hypoxia acclimation. However, the precise mechanisms underpinning ethylene-enhanced survival remain unclear. We studied effect of pretreatment on Arabidopsis (Arabidopsis thaliana) primary root tips. Both itself re-oxygenation following are highly damaging tip cells, pretreatments...
Abstract Light regulates chlorophyll homeostasis and photosynthesis via various molecular mechanisms in plants. The light regulation of transcription protein stability nuclear-encoded chloroplast proteins have been extensively studied, but how mRNA metabolism affects abundance remains poorly understood. Here we show that the blue receptor cryptochrome 2 (CRY2) METTL16-type m 6 A writer FIONA1 (FIO1) regulate response to light. In contrast CRY2-mediated photo-condensation adenosine methylase...
Cytosolic ribosomes are among the largest multisubunit cellular complexes. A rabidopsis thaliana consist of 79 different ribosomal proteins (r‐proteins) that each encoded by two to six (paralogous) genes. It is unknown whether paralogs incorporated into ribosome and relative incorporation r‐protein varies in response environmental cues. Immunopurified were isolated from A. rosette leaves fed with sucrose. Trypsin digested samples analyzed qTOF‐LC‐MS using both MS E classical MS/MS. Peptide...
Environmental factors greatly impact plant gene expression and concentrations of cellular metabolites such as sugars amino acids. The changed metabolite affect the many genes both transcriptionally post-transcriptionally. Sucrose acts a signalling molecule in control translation S1 class basic leucine zipper transcription factor (bZIP) genes. In these main bZIP open reading frames (ORFs) are preceded by upstream (uORFs). presence uORFs generally inhibits following ORF but can also be...
Legumes and rhizobia establish a nitrogen-fixing symbiosis that involves the formation of lateral root organ, nodule, infection process allows intracellular accommodation within nodule cells. This significant gene expression changes regulated at transcriptional post-transcriptional levels. We have previously shown transcript encoding subunit 3 Superkiller Complex (SKI), which guides mRNAs to exosome for 3′-to-5′ degradation, is required bacterial persistence as well induction early...
Translational control is a widespread mechanism that allows the cell to rapidly modulate gene expression in order provide flexibility and adaptability eukaryotic organisms. We applied translating ribosome affinity purification combined with RNA sequencing characterize translational regulation of mRNAs at early stages nitrogen-fixing symbiosis established between
Abstract Crops with resilience to multiple climatic stresses are essential for increased yield stability. Here, we evaluate the interaction between two loci associated flooding survival in rice ( Oryza sativa L.). ANAEROBIC GERMINATION 1 AG1 ), encoding TREHALOSE 6‐PHOSPHATE PHOSPHATASE 7 TPP7 promotes mobilization of endosperm reserves enhance elongation a hollow coleoptile seeds that seeded directly into shallow paddies. SUBMERGENCE SUB1 ethylene‐responsive transcription factor SUB1A‐1 ,...
Randomized controlled trials (RCT) of ultrafiltration (UF) have demonstrated conflicting results regarding its efficacy and safety.
Abstract Abiotic stresses in plants are often transient and the recovery phase following stress removal is critical. Flooding, a major abiotic that negatively impacts plant biodiversity agriculture, sequential where tolerance strongly dependent on viability underwater during postflooding period. Here we show Arabidopsis thaliana accessions (Bay-0 Lp2-6), different rates of submergence correlate with fecundity. A genome-wide assessment ribosome-associated transcripts Bay-0 Lp2-6 revealed...
Abstract Flooded plants experience impaired gas diffusion underwater, leading to oxygen deprivation (hypoxia). The volatile plant hormone ethylene is rapidly trapped in submerged cells and instrumental for enhanced hypoxia acclimation. However, the precise mechanisms underpinning ethylene-enhanced survival remain unclear. We studied effect of pre-treatment on primary Arabidopsis thaliana root tips. Both itself re-oxygenation following are highly damaging tip pre-treatments reduced this...
Abstract Gene transcription is counterbalanced by mRNA decay processes that regulate transcript quality and quantity. We show here the evolutionarily conserved DHH1/DDX6-like RNA HELICASEs of Arabidopsis thaliana control ephemerality a subset cellular mRNAs. These helicases co-localize with key markers processing bodies stress granules contribute to their subcellular dynamics. RHs function limit precocious accumulation translation stress-responsive mRNAs associated autoimmunity growth...