Abnormal expression of cyclooxygenase-2 (COX-2) and prostaglandin (PG)E(2) is an important mediator in inflammation tumor promotion. Arsenite a well-known metalloid carcinogen that strongly associated with increased risk liver cancer, but the underlying mechanism remains to be clarified. The present study demonstrates COX-2 PGE(2) secretion are up-regulated by arsenite rat epithelial (RLE) cells. possible inhibitory effect quercetin, naturally occurring dietary flavonol, on arsenite-induced...

3'-Methoxy-3,4',5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin exerts anticancer effects, but the underlying molecular mechanism for chemopreventive potential of isorhamnetin remains unknown. Here, we report anti-skin cancer effects isorhamnetin, which inhibited epidermal growth factor (EGF)-induced neoplastic cell transformation. It also suppressed anchorage-dependent -independent A431 human epithelial carcinoma cells....

We present a dynamic channel reservation scheme to improve the utilization of wireless network resources while guaranteeing required QoS handoff calls. The channels are dynamically reserved by using request probability determined mobility characteristics and occupancy guarantee acceptable quality calls keep new call blocking as low possible.

<div>Active fuel injection into a pre-chamber (PC) promotes high-temperature and highly turbulent jets, which ignite the cylinder gas with very high exhaust recirculation (EGR) ratio, reducing emissions such as NO<sub>x</sub>. In present study, two active PC strategies were designed to investigate effect of injected hydrogen mass mixture air-to-fuel equivalence ratio <i>λ</i> on combustion, jet formation, main chamber (MC) combustion. Stoichiometric or rich...

In this work, a mathematical heat transfer model of walking-beam type reheating furnace has been developed. The can predict the flux distribution within and temperature in slab throughout process by considering exchange between its surroundings furnace, including radiant among slabs, skids, hot gases wall as well gas convection furnace. filled with combustion such H2O, CO2, O2, N2 is modeled radiating medium spatially varying temperature. After predictions present were compared data from an...

Numerous in vitro and vivo studies have shown that isoflavones exhibit anti-proliferative activity against epidermal growth factor (EGF) receptor-positive malignancies of the breast, colon, skin, prostate. 7,3',4'-Trihydroxyisoflavone (7,3',4'-THIF) is one metabolites daidzein, a well known soy isoflavone, but its chemopreventive underlying molecular mechanisms are poorly understood. In this study, 7,3',4'-THIF prevented EGF-induced neoplastic transformation proliferation JB6 P+ mouse cells....

We evaluated the effects of two main kiwifruit cultivars (gold (GOK) and green (GRK)) their active phenolic compound, quercetin, on H 2 O -induced inhibition gap-junction intercellular communication (GJIC) in WB-F344 rat liver epithelial cells. found that both GOK GRK protect cells from GJIC. The extracellular signal-regulated protein kinase 1/2 (ERK1/2)–connexin 43 (Cx43) signalling pathway is crucial for regulation GJIC, blocked phosphorylation Cx43 ERK1/2 Quercetin alone attenuated...

<div>Pre-chamber turbulent jet ignition (TJI) is a method of generating distributed sites through multiple high-speed jets in order to achieve an enhanced burn rate the engine cylinder when compared conventional spark plug ignition. To study gas-dynamic interactions between two chambers gasoline engine, three-dimensional numerical model was developed using commercial CFD code CONVERGE. The geometry and parameters used were based on modified turbocharged GM four-cylinder 2.0 L GDI...

A LES combustion model for the prediction of wall-heat transfer in rocket engines and confined combustors is developed. The employs a flamelet-formulation, which wall heat-loss effects are introduced by including source term unsteady flamelet equations. This modeled as convective process, evolves on time-scale that slow compared to characteristic chemical scales. employing Nusselt-number relation. thermochemical composition non-adiabatic structure then obtained from solution equations,...

<div>Pre-chamber jet ignition technologies have been garnering significant interest in the internal combustion engine field, given their potential to deliver shorter burn durations, increased stability, and improved dilution tolerance. However, a clear understanding of relationship between pre-chamber geometry, operating condition, formation, performance light-duty gasoline injection engines remains under-explored. Moreover, research specifically focusing on high levels passive...

The two-stage combustion hybrid rocket engine with a gas generator method offers numerous advantages over solid-propellant and classical engines. These include higher specific impulse in operation, lower lifecycle costs, sensitivity to pressure. This study was mainly designed discover whether the fuel-rich effluent coming out from generated meet temperature requirement of less than 1300 K. By using parameters such as oxidizer-to-fuel ratios, oxidizer mass flow rates, grain dimensions, fuel...

We present a rotational Raman spectrum for benzene with single-MHz resolution, more than 100-fold improvement on literature data and sufficient to partially resolve K-splitting in some bands. Spectra frequency range of 0 500 GHz were measured through the observation coherent wave packet time domain over scale 1 microsecond. Spectroscopic frequencies referenced GPS-stabilized clock. Fitted molecular constants B = 5689.2671(±52) MHz, DJ 1178(±50) Hz, DJK -2300(±120) Hz agree results from...

This paper proposes that the addition of ammonium perchlorate to solid fuel in a hybrid gas generator becomes an effective method improving controllability effluent temperature and reducing oxidizer-to-fuel ratio variations. study also examines fuel-rich combustion behavior ammonium-perchlorate-added fuels different chamber pressures, radial profiles, overall system specific impulses. To maintain rocket engine advantages, upper limit is set be 15 wt % fuel. The results proved provided better...

An effective and simple speed ratio control for use in the electronic differentials found electric vehicles is presented. It shown through a small-scale experiment that proposed has better steady-state transient performance than existing independent controls equally distributed torque controls.

<div>This study investigates the behavior of pre-chamber knock in comparison to traditional spark ignition engine knock, using a modified constant-volume gasoline with an optically accessible piston. The aim is provide deeper understanding combustion and its potential for mitigating knock. Five passive pre-chambers different nozzle diameters, volumes, numbers were tested, nitrogen dilution was varied from 0% 10%. stochastic nature necessitates use statistical methods, leading proposal...

<div>Despite the growing prominence of electrified vehicles, internal combustion engines remain essential in future transportation. This study delves into passive pre-chamber jet ignition, a leading-edge technology, offering comprehensive visualization its operation under varying load and dilution conditions light-duty GDI engines. Our primary objectives are to gain fundamental insights ignition subsequent main processes evaluate their response different conditions. We conducted...

In this study, we developed a fiber-optic temperature sensor (FOTS) based on silicone oil and an optical time domain reflectometer (OTDR) to apply the measurement of coolant leakage in nuclear power plant. The sensing probe FOTS consists oil, stainless steel cap, FC terminator, single mode fiber. Fresnel reflection arising at interface between fiber is changed by varying refractive index according temperature. Therefore, measured light signals reflected from probe. measurable range using...