A5076969799- Skin Protection and Aging
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- bioluminescence and chemiluminescence research
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Systemic Sclerosis and Related Diseases
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Medicinal plant effects and applications
- Protein Degradation and Inhibitors
- Phytochemical and Pharmacological Studies
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Virus-based gene therapy research
- Neuroblastoma Research and Treatments
Foshan University
2021-2025
Yantaishan Hospital
2015-2024
Chengdu University
2024
China Pharmaceutical University
2024
Binzhou Medical University
2024
Huaihua University
2024
Sichuan Cancer Hospital
2023
University of Electronic Science and Technology of China
2023
Cancer Society of New Zealand
2022-2023
University of Auckland
2021-2022
3'-Methoxy-3,4',5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin exerts anticancer effects, but the underlying molecular mechanism for chemopreventive potential of isorhamnetin remains unknown. Here, we report anti-skin cancer effects isorhamnetin, which inhibited epidermal growth factor (EGF)-induced neoplastic cell transformation. It also suppressed anchorage-dependent -independent A431 human epithelial carcinoma cells....
Abstract Ultraviolet (UV) irradiation is the leading factor in development of skin cancer, prompting great interest chemopreventive agents for this disease. In study, we report discovery norathyriol, a plant-derived compound identified through an silico virtual screening Chinese Medicine Library. Norathyriol metabolite mangiferin found mango, Hypericum elegans, and Tripterospermum lanceolatum known to have anticancer activity. Mechanistic investigations determined that norathyriol acted as...
Breast cancer is a leading cause of mortality among women with worldwide. Quercetin‑3‑methyl ether, natural compound occurring in various plants, has been indicated to have potent anticancer activity. cell growth and survival were examined by CCK‑8 colony formation assay, whilst cycle apoptosis determined flow cytometry. Cell invasion migration assessed wound‑healing assay Transwell assay. Cancer stem was analyzed mammosphere related signaling pathways detected western blotting. In the...
The activation of cellular signal transduction pathways by solar ultraviolet (SUV) irradiation plays a vital role in skin tumorigenesis. Although many have been studied using pure A (UVA) or B (UVB) irradiation, the signaling induced SUV (i.e., sunlight) are not understood well enough to permit improvements for prevention, prognosis, and treatment. Here, we report parallel protein kinase array studies aimed at determining dominant pathway involved irradiation. Our results indicated that...
Abstract Background Cisplatin (CDDP)‐based chemotherapy has emerged as the primary treatment for muscle‐invasive bladder cancer and metastatic cancer. Nevertheless, a significant proportion of patients experience rapidly developed chemoresistance, leading to ineffectiveness. Existing evidence suggests that chemoresistance is governed by various factors, including tumor stem cells, epithelial mesenchymal transition, reactive oxygen species (ROS). However, limited research been conducted on...
BACKGROUND Diabetic nephropathy (DN) is a common complication of diabetes, caused by diabetic microvascular lesions. The pathogenesis DN complicated, involving genetics, physics, chemistry, and environmental factors. Chemerin fat cell factor that participates in regulating inflammation. Vascular endothelial growth (VEGF) promotes vascular proliferation, differentiation, angiogenesis. relationship role VEGF not fully understood. MATERIAL AND METHODS SD rats were randomly divided into 2...
Target cell proliferation was investigated throughout the development of esophageal cancer induced by N-nitroso-methylbenzylamine (NMBA) in weanhing rats maintained on zinc-deficient or sufficient diets. Deficient were fed ad libitum, while zinc-sufficient either pair-fed to deficient animals libitum. After 5 weeks, half each dietary group given six intragastric doses NMBA (2 mg/kg; twice weekly). The remaining untreated carcinogen. At weeks 1, 2, 3, 4, 5, 7, 9 and 11 post first dose,...
Abstract Lapatinib, an oral, small‐molecule, reversible inhibitor of both EGFR and HER2, is highly active in HER2 positive breast cancer as a single agent combination with other therapeutics. However, resistance against lapatinib unresolved problem clinical oncology. Recently, interest the use natural compounds to prevent or treat cancers has gained increasing because presumed low toxicity. Quercetin‐3‐methyl ether, naturally occurring compound present various plants, potent anticancer...
Chemoprevention has been acknowledged as an important and practical strategy for the management of skin cancer. Quercetin-3-methyl ether, a naturally occurring compound present in various plants, potent anticancer-promoting activity. We identified this by silico virtual screening Traditional Chinese Medicine Database using extracellular signal-regulated kinase 2 (ERK2) target protein. Here, we showed that quercetin-3-methyl ether inhibited proliferation mouse epidermal JB6 P+ cells dose-...
The existence of artificial sponges and antisense oligonucleotides designed to decrease the availability microRNAs (miRNAs), a family small non-coding RNAs that target RNA transcripts through miRNA response elements (MREs) involved in gene expression, suggests miRNAs may also be regulated. wide range harboring MREs, termed competing endogenous (ceRNAs), includes protein-coding messenger (mRNAs) RNAs, for example long pseudogenes circular which compete common pool as natural decoys. These...
Abstract Photodynamic therapy (PDT) is a noninvasive, highly selective approach to the treatment of tumors. However, its therapeutic effect limited by long‐lasting skin phototoxicity. Therefore, compromise this shortcoming, it preferable deliver photosensitizers selectively tumor cells with aid antibodies specific against tumor‐associated antigens. Cancer/testis antigens 83 (CT83), also called KK‐LC‐1 or CXorf61, recognized cytotoxic T lymphocytes (CTL), has become promising target for...
Polygonatum sibiricum (PS) has been used as herbal medicine to treat type 2 diabetes mellitus (T2DM). However, how lactic acid fermentation of PS influences glucose and lipid metabolism remains unclear. The current study was undertaken evaluate the hypoglycemic hypolipidemic effects fermented with Lactobacillus brevis YM 1301 (YM 1301) in streptozotocin high-fat diet-induced T2DM mice. Biochemical analysis revealed that supplementation metformin, PS, or (FPS) lowered fasting blood glucose,...
This study aimed to assess the predictive ability of 18F-FDG PET/CT radiomic features for MYCN, 1p and 11q abnormalities in NB.One hundred twenty-two pediatric patients (median age 3. 2 years, range, 0.2-9.8 years) with NB were retrospectively enrolled. Significant by multivariable logistic regression retained establish a clinical model (C_model), which included characteristics. extracted Computational Environment Radiological Research. The least absolute shrinkage selection operator (LASSO)...
The mitochondrial A3243G tRNALeu(UUR) mutation associated with a variety of disorders results in severe respiratory deficiency, an increase reactive oxygen species (ROS) production and activities anti-oxidative enzyme vitro. However, the phenotypic implications this have not been described vivo. Here, mitochondria carrying transition from peripheral blood diabetes mellitus patients were microinjected into zygotes. Influence on activities, ROS generation, heteroplasmic tissues...
Research on neural stem cells (NSCs) has recently focused microRNAs (miRNAs), a class of small non‑coding RNAs that have crucial roles in regulating NSC proliferation and differentiation. In the present study, quantitative‑polymerase chain reaction assay revealed expression miRNA (miR)‑138‑5p was significantly decreased during differentiation NSCs vitro. Overexpression miR‑138‑5p reduced increased Furthermore, suppression via transfection with inhibitor enhanced attenuated Additionally,...
Activation of receptor tyrosine kinases (RTK) plays a key role in the prognosis mammary cancer. Lapatinib is small molecule dual RTK inhibitor that targets epidermal growth factor (EGFR) and human 2 (HER2). Identifying protein involved effects lapatinib other inhibitors might help determine why preventive efficacy varies. In this study, female Sprague-Dawley rats were given methylnitrosourea (MNU) by intravenous injection resulting development multiple estrogen receptor-positive tumors....
18F-fluorodeoxyglucose (FDG) PET/CT is often used for detecting malignancy in patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH), acceptable sensitivity but relatively low specificity. The aim of this study was to improve the diagnostic ability 18F-FDG identifying HLH by combining and clinical parameters.Ninety-seven (age ≥ 14 years) secondary were retrospectively reviewed divided into derivation (n = 71) validation 26) cohorts according admission time. In cohort, 22 had...
Bovine mammary epithelial stem cells (MESCs) are very important in agricultural production and bioengineering. In the present study, we compared different isolation culture methods for MESCs observed their growth differentiation characteristics. have an extremely weak proliferation capacity, it is difficult to obtain prolong subculture of a bovine cell line. We obtained some multipotent MESC aggregates that looked like spherical colonies. These colonies were only derived from suspension...