A5014479939- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Hematological disorders and diagnostics
- Adrenal and Paraganglionic Tumors
- Cytomegalovirus and herpesvirus research
- Intracranial Aneurysms: Treatment and Complications
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Kawasaki Disease and Coronary Complications
- Bone and Joint Diseases
- Vascular anomalies and interventions
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Virus-based gene therapy research
Capital Medical University
1992-2025
Beijing Friendship Hospital
1996-2025
Capital University
2024
Vienna General Hospital
2024
Medical University of Vienna
2024
National Natural Science Foundation of China
2021-2023
Tongji Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Huazhong University of Science and Technology
2022
Ministry of Education of the People's Republic of China
2022
Abstract Objective To develop and validate an 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)-based radiomics nomogram for non-invasively prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. Methods A total 133 patients with neuroblastoma were retrospectively included randomized into the training set ( n = 93) test 40). Radiomics features extracted from both CT PET images. The signature was developed. Independent clinical risk...
Parasite egg-induced granulomas are the primary pathogenic lesions in murine schistosomiasis mansoni. This cell-mediated granulomatous response is specific for soluble egg Ag and appears to be mediated predominantly by CD4+ Th2 cells. As infection progresses from acute chronic phase, anti-soluble responses attenuate a process termed modulation. In this study hypothesis that modulation effected phase increase Th2-inhibiting Th1 cell activity was investigated. Northern blot quantification of...
Abstract 123 I-MIBG SPECT/CT was performed for follow-up in an asymptomatic 8-year-old girl with a history of neuroblastoma. The images showed unsuspected abnormal accumulation the head, which identified as hyperdense lesion dura increasing MIBG uptake, suggesting possibility metastasis from A brain MRI contrast remarkably enhanced beside confluence sinuses, mimicked meningioma. Results surgical pathology are consistent diagnosis dural
Transcranial magnetic stimulation (TMS) is a method of noninvasive brain that causes neuromodulation by activating neurons or changing excitability in certain area. Considering the known effects TMS and pathophysiology traumatic injury (TBI), was proposed to have potential for treating this condition. Moderate TBI induced adult male Sprague Dawley rats using Feeney's weight-dropping method. Injured were divided into group control group. Repetitive (rTMS) administered from post-TBI day 2. At...
Objectives . To explore the diagnostic value of 18 F‐FDG PET/CT bone marrow uptake pattern (BMUP) in detecting involvement (BMI) pediatric neuroblastoma (NB) patients. Methods Ninety‐eight NB patients were enrolled BMI analysis. Four patterns categorized based on pretreatment c images. Some crucial inspection indexes and metabolic parameters analyzed. The BMUP was divided into BMUP1, BMUP2, BMUP3, BMUP4. Paired‐like homeobox 2b (PHOX2B) blood, biopsy (BMB) result, compared to detect BMI. All...
To evaluate the role of pre-therapeutic 18F-FDG PET/CT in pediatric hemophagocytic lymphohistiocytosis (HLH) with Epstein-Barr virus (EBV) infection.This retrospective study included 29 HLH children (1-16 years) EBV infection, who underwent from July 2018 to November 2020. Pathology results were considered as reference standard. These patients divided into two groups: EBV-induced malignancy-associated (M-HLH, N = 9) and non-malignancy-associated (NM-HLH, 20). The regions interest (ROIs)...
18F-fluorodeoxyglucose (FDG) PET/CT is often used for detecting malignancy in patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH), acceptable sensitivity but relatively low specificity. The aim of this study was to improve the diagnostic ability 18F-FDG identifying HLH by combining and clinical parameters.Ninety-seven (age ≥ 14 years) secondary were retrospectively reviewed divided into derivation (n = 71) validation 26) cohorts according admission time. In cohort, 22 had...
Cholecystokinin octapeptide (CCK-8) has been shown to be coupled phosphoinositide turnover in pancreatic acini as well a kind of neuroblastoma cell and human embryonic line. Little is known, however, about its link with phosphatidylinositol breakdown the brain. The brains (minus cerebella) from 1-2-day-old neonatal rats were enzymically dissociated into single cells. intact cells prelabelled by incubation myo-[3H]inositol for 3 h, then stimulated agonists presence 10 mM-LiCl. Carbachol at 1...
Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially fatal illness, which can be divided into primary HLH (pHLH) and secondary (sHLH). pHLH driven by genetic defections. Moreover, the sHLH usually triggered malignancy or non‐malignancy diseases. Sixty‐two newly diagnosed patients with known etiology those who underwent 18 F‐FDG PET/CT examination from July 2018 to December 2020 were retrospectively analyzed. They malignancy‐associated (M‐HLH, n = 13) non‐malignancy‐associated...
To evaluate the diagnostic performance of combined multiparametric 18F-fluorodeoxyglucose positron emission tomography (18FDG PET) with clinical characteristics in differentiating thymic epithelial tumors (TETs) from lymphomas.A total 173 patients 80 TETs and 93 lymphomas who underwent 18F-FDG PET/CT before treatment were enrolled this retrospective study. All confirmed by pathology, baseline data also collected. The semi-parameters PET/CT, including lesion size, SUVmax (maximum standard...
A 24-year-old man with a history of hemophagocytic lymphohistiocytosis (HLH) presented swelling the left foot and skin ulcer. The patient received bone marrow transplantation for HLH 3 years ago his HLH. Biopsy demonstrated primary cutaneous natural killer/T-cell lymphoma: posttransplant lymphoproliferative disorder. FDG PET/CT images multiple foci abnormal accumulation in body, especially skin. Follow-up after chemotherapy that most activities disappeared except lesion foot.
Calcification has been proven to be a marker of atherosclerosis and is related an increased risk ischemic stroke. Additionally, calcification was reported prevalent in patients with stenotic lesions the intracranial vertebral artery. Thus, reliable imaging facilities for evaluating plaque have remarkable significance guiding stenting predicting patient outcomes. Optical coherence tomography (OCT) unique advantage its ability detect calcium achieve three-dimensional volumetric...
Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe disease with poor prognosis. We aimed to determine if 18F-fluorodeoxyglucose (18F-FDG) PET/CT-derived radiomic features alone or combination clinical parameters could predict survival in adult HLH. Methods: This study included 70 adults HLH (training cohort, n = 50; validation 20) who underwent pretherapeutic 18F-FDG PET/CT scans between August 2016 June 2020. Radiomic were extracted from the liver spleen on CT PET...
C-arm cone-beam computed tomography (CBCT) offers a high imaging resolution with wide range of contrast to visualize vessels, soft tissue, and bone. We report the usefulness CBCT in observing neovascularization, microcalcification, plaque rupture. A 56-year-old man presented vertigo complain an unsteady gait for 5 months. Catheter angiography demonstrated right severe carotid stenosis irregular filling defect, which on high-resolution MRI showed vessel wall enhancement. The density...
A 41-year-old woman received stem cell transplant due to acute myeloid leukemia. Six months after the transplant, patient experienced monomorphic PTLD (posttransplant lymphoproliferative disorder) and underwent chemotherapy. Postchemotherapy PET/CT did not show any abnormal 18 F-FDG accumulation in scanned body, including brain. Four later, she presented with nausea vomiting. Brain MRI showed a lesion right temporal lobe. In addition brain, no other foci were noted torso PET/CT. Biopsy...
<title>Abstract</title> Background The hyperinflammatory condition and lymphoproliferation due to Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) affect the detection of lymphomas by <sup>18</sup>F-FDG PET/CT. We aimed improve diagnostic capabilities PET/CT combining laboratory parameters. Methods This retrospective study involved 46 patients diagnosed with EBV-positive HLH, who underwent before beginning chemotherapy within a 4-year timeframe. These were...
Abstract Coexistence of Langerhans cell histiocytosis and ganglioneuroblastoma is rare seldom reported in the literature. A 3-year-old girl with underwent 18 F-FDG PET/CT imaging for staging, which demonstrated significant accumulation mandibles. Unexpectedly, a mild hypermetabolic soft mass was detected upper retroperitoneum. Results surgical pathology abdominal were consistent ganglioneuroblastoma.
Abstract Background The hyperinflammatory condition and lymphoproliferation due to Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) affect the detection of lymphomas by 18 F-FDG PET/CT. We aimed improve diagnostic capabilities PET/CT combining laboratory parameters. Methods This retrospective study involved 46 patients diagnosed with EBV-positive HLH, who underwent before beginning chemotherapy within a 4-year timeframe. These were categorized into two groups:...