A5063862414- Renal Diseases and Glomerulopathies
- Poisoning and overdose treatments
- Mosquito-borne diseases and control
- Parasitic infections in humans and animals
- Epilepsy research and treatment
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- Research on Leishmaniasis Studies
- Ion channel regulation and function
- Venomous Animal Envenomation and Studies
- Acute Kidney Injury Research
- Infectious Diseases and Tuberculosis
- Autoimmune Bullous Skin Diseases
- Pediatric Urology and Nephrology Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Cerebral Palsy and Movement Disorders
- Renal function and acid-base balance
- Pneumonia and Respiratory Infections
- Infectious Encephalopathies and Encephalitis
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Drug-Induced Hepatotoxicity and Protection
Banaras Hindu University
2016-2025
Institute of Medical Sciences
2016-2025
Adesh University
2022
Indian Institute of Technology BHU
2009-2021
Pediatrics and Genetics
2005-2016
All India Institute of Medical Sciences
2013
Post Graduate Institute of Medical Education and Research
2009
B.P. Koirala Institute of Health Sciences
2002-2007
Nalanda Medical College and Hospital
2004-2006
Wordsley Hospital
2006
Fifty cases of severe malaria were studied for their oxidant and antioxidant status. Severe anemia (54%) was the most common presentation followed by hyperpyrexia, cerebral jaundice. Plasma malondialdehyde, protein carbonyl, nitrite, ascorbic acid copper levels significantly raised in as compared with controls (p < 0.001). ceruloplasmin, glutathione superoxide dismutase decreased children zinc increased but difference is not statistically significant. Significantly level nitrites value found...
PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily molecules important for cell motility, and implicated in cancer progression. Here we investigated multiple families from Oman, India, Iran Italy with individuals affected by new autosomal recessive neurodevelopmental degenerative disorder which cardinal features include primary microcephaly profound global developmental delay. Our genetic studies identified biallelic mutations PRUNE1 as responsible. functional...
Background Peritoneal dialysis (PD) is the preferred and convenient treatment modality for acute kidney injury (AKI) in children hemodynamically unstable patients. Methods The outcome of PD was studied 57 (39 boys) with AKI, aged 1 month to 12 years, at a tertiary care center teaching hospital India. Results Hemolytic uremic syndrome (36.8%) most common cause followed by septicemia (24.6%) tubular necrosis (19.3%). Treatment highly effective lowering retention markers ( p < 0.001)....
The usefulness of maternal anthropometric parameters i.e. weight (MWt), height (MHt), mid-arm circumference (MMAC) and body mass index (MBMI) as predictors low birth (LBW) was studied in 395 singleton pregnancies. were measured the first trimester pregnancy plotted against newborns. Significant positive correlations observed among MWt (r=0.38), MHt (r=0.25), MMAC (r=0.30) MBMI (r=0.30). most sensitive being (t=7.796), followed by (t=5.759), (t=4.706) (t=5.89). For prediction LBW, critical...
Abstract Background: A hospital‐based prospective cross‐sectional study was conducted in children aged 1 month–14 years to identify the proportion of viral encephalitis due Japanese (JE) and compare clinico‐laboratory profile outcome JE with that other (non‐JE). Methods: All probable cases on clinical laboratory evaluation were confirmed as anti‐JE IgM cerebrospinal fluid (CSF) and/or serum. Patients not having CSF serum diagnosed non‐JE. Results: Of 94 cases, 58 36 Although practice rearing...
Glucocorticoid therapy in children with nephrotic syndrome can lead to many adverse effects including behavioural problems. The present study was undertaken assess the changes individual behaviour among different sub-groups of patients idiopathic (INS) and also find out relationship, if any, between problems cumulative dose steroid therapy.This a prospective hospital-based study. We assessed patterns 131 adolescents steroid-responsive INS aged 1.5-15 years. Fifty healthy matched for age...
The objective of the present study was to find out predictors relapse. One hundred fifty children with a first episode idiopathic nephrotic syndrome were followed for 12 months after initial treatment. Sixty-one (40.7%) had no relapse, and 89 (59.3%) relapses. A significantly higher proportion disease onset between 1 3 years relapsers in comparison those at 4-6 (p < 0.03) 7-13 0.001) years. Risk relapse 2.99 times this 1-3 year age-group as compared patients aged >6 = 0.001). Children...
Tuberculosis is characterized by extensive destruction and remodelling of the pulmonary extracellular matrix. Stromal cell-derived matrix metalloproteinases (MMPs) are implicated in this process may be a target for adjunctive immunotherapy. We hypothesized that MMPs elevated bronchoalveolar lavage fluid tuberculosis patients antimycobacterial agents have modulatory effect on MMP secretion. Concentrations MMP-1, -2, -3, -7, -8, -9 were from compared to those with other conditions. There was...
Abstract Epitope imprinting is a promising technique for fabrication of novel diagnostic tools. In this study, an epitope imprinted methodology recognition target sequence as well targeted protein infused by bacterial infection in blood samples patients suffering from brain fever developed. Template chosen ferric iron binding fbp A present Neisseria meningitidis bacteria. To orient the template peptide on gold surface electrochemical quartz crystal microbalance (EQCM), thiol chemistry was...
Background Cow's milk protein causes an unfavorable and unwanted reaction in some individuals called cow's allergy (CMPA). It is more often imprecise easily missed primary care settings. Milk-related Symptom Score (CoMiSS) was developed as a screening awareness tool to suggest the presence of CMPA using general, dermatological, gastrointestinal, respiratory symptoms. Objective Assess utility CoMiSS diagnosis Indian children aged between 0 24 months. Methods A pilot multicentric,...
Japanese encephalitis (JE) is associated with high mortality and neurological sequelae. The unpredictable course lack of specific treatment pose major challenges in management. tropical climate paddy ecosystem Nepal provide a suitable setting.To determine the aetiology febrile encephalopathy describe clinico-laboratory profile outcome JE Nepali children.A hospital-based prospective observational study was conducted over 1-year period (2000-2001). Children aged from >1 month to 14 years fever...
In the absence of primary care and prevailing associated social stigma, many patients neural tube defects (NTDs) from remote areas die without getting any treatment. The high number such untreated cases unregistered deaths in these made us ponders to fact that tertiary center-based studies do not represent true incidence NTDs.We did a population-based survey for NTDs births rural Jaunpur Ghazipur district Eastern Uttar Pradesh. These districts are among least developed Northern India Pradesh...
Epitope imprinting has shown better prospects to synthesize synthetic receptors for proteins. Here, dual epitope imprinted polymer electrode (DEIP) matrix was fabricated on gold surface of electrochemical quartz crystal microbalance (EQCM) recognition target sequence in blood samples patients suffering from brain fever. sequences outer membrane protein Por B Neisseria meningitidis (MC58) bacteria predicted through immunoinformatic tools were chosen imprinting. Self-assembled monolayers (SAM)...
<h3>Objectives:</h3> The effect of delayed analysis on cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose has never been studied in neonates. <h3>Design:</h3> Prospective cohort study. <h3>Setting:</h3> Level III newborn unit. <h3>Patients:</h3> Neonates undergoing lumbar puncture were enrolled after consent. CSF was analysed at baseline (30 minutes) for protein, WBC glucose; from the same sample a lag 2 h 4 puncture. Those with traumatic/inadequate excluded. Subjects...
The exact etiopathogenesis of febrile seizures (FS) is unknown. present study was conducted to evaluate the cerebrospinal fluid (CSF) zinc (Zn), magnesium (Mg), copper (Cu) and gamma-aminobutyric acid (GABA) levels in children with FS. subjects included 20 cases FS, 26 patients encephalitis 22 fever meningismus. Zn, Mg Cu CSF serum were analyzed by atomic absorption spectrophotometry GABA estimated paper chromatography method. mean values significantly decreased FS comparison meningismus...