A5053473589- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
Mendel University in Brno
2022-2024
Ferritins are globular proteins with an internal cavity that enables the encapsulation of a plethora low-mass compounds. Unfortunately, overall negative surface charge ferritin's hampers efficient loading negatively charged molecules. Therefore, we produced genetically engineered human H-chain ferritin containing cationic RKRK domain, reversing natural net to positive, thus allowing for siRNA. Due reversed, positive mediated by domains, recombinant in E. coli inherently carries load...
Background: As highlighted by recent pandemic outbreaks, antiviral drugs are crucial resources in the global battle against viral diseases. Unfortunately, most characterized a plethora of side effects and low efficiency/poor bioavailability owing to their insolubility. This also applies arylnaphthalide lignin family member, diphyllin (Diph). Diph acts as vacuolar ATPase inhibitor has been previously identified promising candidate with broad-spectrum activity. However, its physicochemical...