A5023311530- Iron Metabolism and Disorders
- Nanoparticle-Based Drug Delivery
- Neuroblastoma Research and Treatments
- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Nanoparticles: synthesis and applications
- Crystallization and Solubility Studies
- Signaling Pathways in Disease
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Cellular transport and secretion
- Clostridium difficile and Clostridium perfringens research
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
- Nanoplatforms for cancer theranostics
- Selenium in Biological Systems
- Moringa oleifera research and applications
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Research Studies
- Folate and B Vitamins Research
Mendel University in Brno
2020-2022
Brno University of Technology
2020-2022
Central European Institute of Technology
2020-2022
Purpose: The present study deals with the in vitro evaluation of potential use coordination compound-based zinc oxide (ZnO) nanoparticles (NPs) for treatment triple negative breast cancer cells (TNBrCa). As BrCa is one most prevalent types and TNBrCa difficult due to poor prognosis a high metastasis rate, finding more reliable option should be utmost interest. Methods: Prepared by reacting carboxylates (formate, acetate, propionate, butyrate, isobutyrate, valerate) hexamethylenetetramine, 4...
Although the general concept of nanotechnology relies on exploitation size-dependent properties nanoscaled materials, relation between size/morphology nanoparticles with their biological activity remains not well understood. Therefore, we aimed at investigating Se nanoparticles, one most promising candidates nanomaterials for biomedicine, possessing same crystal structure, but differing in morphology (nanorods vs. spherical particles) and aspect ratios (AR, 11.5 22.3 1.0) human cells BALB/c...
Abstract Background Currently, the diagnosis and treatment of neuroblastomas—the most frequent solid tumors in children—exploit norepinephrine transporter (hNET) via radiolabeled analogs. We aim to develop a nanomedicine-based strategy towards precision therapy by targeting hNET cell-surface protein with hNET-derived homing peptides. Results The peptides ( seq. GASNGINAYL SLWERLAYGI) were shown bind high-resolution homology models silico. In particular, one unique binding site has marked...
The present study reports on examination of the effects encapsulating tyrosine kinase inhibitors (TKIs) vandetanib and lenvatinib into a biomacromolecular ferritin-based delivery system.The encapsulation TKIs was performed via two strategies: i) using an active reversible pH-dependent reassembly ferritin´s quaternary structure ii) passive loading hydrophobic through channels at junctions ferritin subunits. After encapsulation, ferritins were surface-functionalized with folic acid promoting...
A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van primarily used for treatment advanced or metastatic medullary thyroid cancer; however, its usage significantly limited by side effects, particularly cardiotoxicity. One approach to minimize them encapsulation binding in- onto a suitable carrier, allowing targeted delivery tumor tissue. Herein, we constructed nanocarrier based on apoferritin associated with...