A5074425332- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Long-Term Effects of COVID-19
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Autism Spectrum Disorder Research
- Musculoskeletal pain and rehabilitation
- Infectious Encephalopathies and Encephalitis
- Prion Diseases and Protein Misfolding
- Glioma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Laser Applications in Dentistry and Medicine
- Eicosanoids and Hypertension Pharmacology
- COVID-19 and Mental Health
- Osteoarthritis Treatment and Mechanisms
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
McLean Hospital
2025
Harvard University
2020-2025
Massachusetts General Hospital
2020-2024
Athinoula A. Martinos Center for Biomedical Imaging
2020-2024
KU Leuven
2016-2023
VIB-KU Leuven Center for Brain & Disease Research
2023
California State University, East Bay
2017
Abstract Background and Hypothesis Convergent evidence shows the presence of brain metabolic abnormalities in psychotic disorders. This study examined reductive stress energy metabolism people with disorders impaired or average range cognition. We hypothesized that global cognitive impairment would be associated greater dysregulation. Study Design Participants affective non-affective psychosis (n = 62) were administered MATRICS Consensus Cognitive Battery (MCCB) underwent a 31P-magnetic...
Abstract Converging preclinical evidence links extrastriatal dopamine release and glutamatergic transmission via the metabotropic glutamate receptor 5 (mGluR5) to rewarding properties of alcohol. To date, human is lacking on how where in brain these processes occur. Mesocorticolimbic upon intravenous alcohol administration mGluR5 availability were measured 11 moderate social drinkers by single‐session [ 18 F]fallypride F]FPEB positron emission tomography, respectively. Additionally, baseline...
Abstract The weak association between disability levels and “peripheral” (ie, knee) findings suggests that central nervous system alterations may contribute to the pathophysiology of knee osteoarthritis (KOA). Here, we evaluated brain metabolite in patients with KOA, before after total arthroplasty (TKA), using 1H-magnetic resonance spectroscopy (MRS). Thirty-four presurgical KOA 13 healthy controls were scanned a PRESS sequence (TE = 30 ms, TR 1.7 seconds, voxel size 15 × mm). In addition,...
<h3>SUMMARY:</h3> Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient COVID-19-associated necrotizing leukoencephalopathy, another who had a recent pulseless electrical activity cardiac arrest subtle white matter changes, and without frank encephalopathy or severe hypoxic episode. The findings were compared those of 2 pathology not related to Severe Acute Respiratory Syndrome infection healthy...
Heritable temperament traits have been linked to several neuropsychiatric illnesses, including disorders associated with metabotropic glutamate receptor 5 (mGluR5) and dopaminergic dysfunctions. Considering its modulating effect on neurotransmission, we hypothesized that cerebral mGluR5 availability is in healthy humans. <b>Methods:</b> Forty-four nonsmoking volunteers (mean age ± SD, 40 14 y; range, 22–66 22 women) were included this cross-sectional investigation. Brain was quantified both...
Cocaine addiction is a disorder that still lacks diagnostic biomarkers or effective pharmacotherapy. We present findings on rat model of cocaine self-administration was followed up longitudinally using the metabotropic glutamate receptor type 5 (mGluR5) tracer <sup>18</sup>F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile (<sup>18</sup>F-FPEB) PET, proton MR spectroscopy (<sup>1</sup>H-MRS), and behavioral tests. <b>Methods:</b> Forty-two Wistar rats were scanned with <sup>18</sup>F-FPEB PET...
Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease primarily characterized by progressive degeneration of motor neurons in the cortex, brainstem and spinal cord. Due to relatively fast progression ALS, early diagnosis essential for possible therapeutic intervention management. To identify potential diagnostic markers, we investigated age-dependent effects onset on regional neurochemistry SOD1G93A ALS mouse model using localized vivo magnetic resonance spectroscopy...
Abstract To study the role of glutamatergic system in alcohol abuse disorders, we conducted a longitudinal exposure rats. Rats were followed with 1 H‐magnetic resonance spectroscopy during baseline, and abstinence phase to measure prefrontal glutamate glycine concentrations. Additionally, 18 F‐FPEB PET was used assess metabotropic receptor 5 (mGluR5) availability before after or saccharin. Finally, individual anxiety levels assessed an open field test at baseline. We found that total...
Background Patients with recurrent glioblastoma (GBM) are often treated antiangiogenic agents, such as bevacizumab (BEV). Despite therapeutic promise, conventional MRI methods fail to help determine which patients may not benefit from this treatment. Purpose To use MR spectroscopic imaging (MRSI) intermediate and short echo time measure corrected myo-inositol (mI)normalized by contralateral creatine (hereafter, mI/c-Cr) in participants GBM BEV investigate whether measurements can predict...
Abstract Whether brain matter volume is correlated with cognitive functioning and higher intelligence controversial. We explored this relationship by analysis of data collected on 193 healthy young older adults through the “Leipzig Study for Mind–Body–Emotion Interactions” (LEMON) study. Our involved four measures: fluid intelligence, crystallized flexibility, working memory. Brain subregion volumes were determined magnetic resonance imaging. normalized each to estimated total intracranial...
Aging is associated with alterations in the brain including structural and metabolic changes.Previous research has focused on neurometabolite level differences to age a variety of regions, but relationship among metabolites across been much less studied.Investigating these relationships can reveal underlying neurometabolic processes, their interdependency, progress throughout lifespan.Using 1 H-MRS, we investigated metabolite concentrations N-acetylaspartate (NAA), creatine (Cr), choline...
We report on the rationale and design of an ongoing National Institute Mental Health (NIMH) sponsored R61-R33 project in major depressive disorder (MDD). Current treatments for MDD have significant limitations efficacy side effect burden. There is a critical need device-based that are efficacious, well-tolerated, easy to use. This focuses adjunctive use transcranial photobiomodulation (tPBM) with near-infrared (NIR) light treatment MDD. tPBM NIR penetrates robustly into cerebral cortex,...
Background Recently, several promising treatments for high-grade gliomas (HGGs) failed to provide significant benefit when translated from the preclinical setting patients. Improving animal models is fundamental overcome this translational gap. To address need, we developed and comprehensively characterized a new in-vivo model based on orthotopic implantation of CT-2A cells cultured in neurospheres (NS/CT-2A). Methods Murine methylcholanthrene-induced HGG (C57BL/6 background) were monolayers...
Currently TAR DNA binding protein 43 (TDP-43) pathology, underlying Amyotrophic Lateral Sclerosis (ALS), remains poorly understood which hinders both clinical diagnosis and drug discovery efforts. To better comprehend the disease pathophysiology, positron emission tomography (PET) multi-parametric magnetic resonance imaging (mp-MRI) provide a non-invasive mode to investigate molecular, structural, neurochemical abnormalities in vivo. For first time, we report findings of longitudinal PET-MR...
Neurological complications of the COVID-19 infection may be caused in part by local neurochemical and structural abnormalities that could not detected during routine medical examinations. We examined within subject neurometabolic brain alterations from pre-to post-COVID-19 hippocampal region three elderly individuals (aged 63-68 years) who had a with mild symptoms. Patients were participating an interventional study which they closely monitored at time diagnosed COVID-19. 1 2 just completed...
Autism spectrum disorder (ASD) and schizophrenia (SZ) are neuropsychiatric disorders that overlap in symptoms associated with social-cognitive impairment. Subcortical structures play a significant role cognitive social-emotional behaviors their abnormalities conditions. This exploratory study utilized ABIDE II/COBRE MRI corresponding phenotypic datasets to compare subcortical volumes of adults ASD (n = 29), SZ 51) age gender matched neurotypicals (NT). We examined the association between...