A5101798956- interferon and immune responses
- RNA regulation and disease
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Multiple Myeloma Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Click Chemistry and Applications
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- Evolution and Genetic Dynamics
- Microbial Community Ecology and Physiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromatin Remodeling and Cancer
GlaxoSmithKline (United Kingdom)
2014-2022
Harvard University Press
2021-2022
Age UK
2021
The Wistar Institute
2004
University of Liverpool
2004
Babraham Institute
2002
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, best-characterized entry receptor for disease-causing virus SARS-CoV-2, is highly expressed in aforementioned tissues. However, pathways that underlie are still poorly understood. Here, we unexpectedly found complement system was one intracellular most induced by SARS-CoV-2 infection lung epithelial cells....
Are better drugs just a click away? Drugs that show promise in preclinical models often fail the clinic, part because of limited information on drug localization within cells and across tissues. In proof-of-concept study, Tyler et al. applied chemistry methods to study bromodomain inhibitors. These are cancer alter chromatin structure gene expression. Clickable derivatives localized showed exhibit distinct modes binding at responsive unresponsive genes. mouse leukemia model, click-probes...
Differentiation and activation of T cells require the activity numerous histone lysine methyltransferases (HMT) that control transcriptional cell output. One most potent regulators differentiation is HMT Ezh2. Ezh2 a key enzymatic component polycomb repressive complex 2 (PRC2), which silences gene expression by H3 di/tri-methylation at 27. Surprisingly, in many types, including cells, localized both nucleus cytosol. Here we show presence nuclear-like PRC2 cytosol demonstrate role cytosolic...
On the human long-arm pseudoautosomal region (XqPAR), genes that are subject to inactivation closely linked with those escape. Genes not only silenced on inactive X in females, but they also inactivated Y chromosome males. One of this unusual pattern is synaptobrevin-like 1 gene (SYBL1). Previously we showed its silencing and allele involves DNA methylation. This study explores molecular events associated SYBL1 investigates their relationship. Promoter methylation profiles were determined by...
The bromodomain and extra terminal (BET) family of proteins are an integral part human epigenome regulation, the dysregulation which is implicated in multiple oncology inflammatory diseases. Disrupting BET acetyl-lysine (KAc) histone protein-protein interaction with small-molecule KAc mimetics has proven to be a disease-relevant mechanism action, molecules currently undergoing clinical trials. This work describes efficiency analysis published GSK pan-BET inhibitors, drove strategic choice...
Histone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression HDACs, clinical utility HDACi is limited by off-target Esterase-sensitive motif [ESM] technology aims to deliver ESM-conjugated compounds human mononuclear myeloid cells, based on their carboxylesterase 1 [CES1]. This study investigate an ESM-tagged in inflammatory bowel disease [IBD].CES1 was assessed blood, vitro differentiated macrophage and dendritic Crohn's [CD] colon...
Abstract Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 (ACE2), best-characterized entry receptor for disease-causing virus SARS-CoV-2, is highly expressed in aforementioned tissues. However, pathways that underlie are still poorly understood. Here, we unexpectedly found complement system was one intracellular most induced by SARS-CoV-2 infection lung...