A5074008345- Hepatitis C virus research
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Biological Research and Disease Studies
- Rheumatoid Arthritis Research and Therapies
- Liver Diseases and Immunity
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cystic Fibrosis Research Advances
- Forensic and Genetic Research
- Genetic Associations and Epidemiology
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Hemophilia Treatment and Research
- Protein purification and stability
- Parvovirus B19 Infection Studies
- Ophthalmology and Eye Disorders
- Testicular diseases and treatments
- Medical and Biological Ozone Research
- Ocular Diseases and Behçet’s Syndrome
- Biochemical and Molecular Research
- Hepatitis Viruses Studies and Epidemiology
- Gene expression and cancer classification
Hospital Italiano La Plata
2019-2024
Universidade Federal do Rio Grande do Sul
2007-2022
Secretaria da Saúde
2017-2022
Faculdade Redentor
2022
Fundação Estadual de Produção e Pesquisa em Saúde
2004-2015
Universidade Luterana do Brasil
2015
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
2009
Hepatitis C virus (HCV) isolates have been divided into six genotypes (1 to 6). The duration of hepatitis standard treatment is 48 weeks for patients infected with HCV genotype 1 vs 24 those 2 and 3. A total 1544 from chronic living in the southern Brazilian states Rio Grande do Sul (RS, n = 627) Santa Catarina (SC, 917) were genotyped by restriction fragment length polymorphism (RFLP) polymerase chain reaction (PCR) products. In RS, 338 (53.9%; 95% CI 50.0 - 57.8%), 34 (5.4%; 3.8 7.4%) and,...
Hepatitis B virus genotype A1 (HBV/A1), of African origin, is the most prevalent in Brazil, while HBV/F predominates other South American countries. However, HBV/D common three states southern where 'islands' elevated prevalence, as Chapecó and cities, have been described. In this study, 202 HBV chronic carriers attending 2013 viral hepatitis ambulatory Chapecó, were investigated. comparison with previous studies performed same ambulatory, a rapid aging infected population was observed (mean...
A number of studies have demonstrated associations between cytokine gene polymorphisms and outcome hepatitis B virus (HBV) infection. However, no general consensus has been reached, possibly due to differences ethnic groups. In this study, 345 individuals living in southern Brazil, including 196 chronic HBV carriers 149 subjects who had spontaneously recovered from acute infection, were enrolled evaluate the influence on Most participants European descent. Genotyping IL2-330 G/T, IL4-589C/T,...
Non-tuberculous mycobacteria (NTMs) cause diseases known as mycobacteriosis and are an important of morbidity mortality. The diagnosis pulmonary disease caused by NTM is hampered its clinical similarity with tuberculosis (TB) the lack accurate rapid laboratory diagnosis.Detect DNA from NTMs directly lung samples using real-time polymerase chain reaction (qPCR) for amplification 16S rRNA. Additionally, sequencing (hsp65 rpoB genes) was used to identify species MNTs.A total 68 sputum (54...
A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor the outcome chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim this study to investigate association between IL28B gene (rs12979860) and virological response in patients. Brazilian (n = 263) who were infected virus (HCV) genotype 1 receiving PEG-IFN/RBV genotyped. Early (EVR) (12 weeks), end-of-treatment (EOTR) (48...
Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs promoters interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) tumour necrosis factor (TNF) (-308 G/A, rs1800629 -238 rs361525) genes outcome PEGylated α-interferon plus ribavirin therapy were investigated. This analysis was performed 114...
Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and proportion people infected human immunodeficiency virus (HIV) among patients TB. Hepatitis C (HCV) infection increases risk anti-TB drug-induced hepatotoxicity, which may result in discontinuation therapy.The aim this study was (i) to estimate prevalence HCV HIV a group newly diagnosed active TB public reference hospital (ii) compare demographic, behavioural, clinical characteristics relation...
<h3>Background:</h3> The need for glucocorticoid sparing drugs (GCSD) remains an important issue and is unmet in the treatment of polymyalgia rheumatica (PMR). <h3>Objectives:</h3> We therefore assessed effectiveness safety methotrexate (MTX) leflunomide (LEF) daily clinical practice PMR patients from Argentina. <h3>Methods:</h3> A multicenter observational study (medical records review) seen between 2007 2023, who had at least three months follow-up after starting a GCSD, either MTX or LEF,...
<h3>Background:</h3> Primary systemic vasculitis are a heterogeneous group of diseases characterized by inflammatory involvement the blood vessel wall leading to organ damage. Taking into account severity complications this disease, it is interesting determine which those that required hospitalization and evaluate factors associated with mortality in these patients. <h3>Objectives:</h3> To estimate frequency patients diagnosed primary who its possible predictors. <h3>Methods:</h3> We...
This study describes a colorimetric method for detecting and genotyping hepatitis C virus (HCV) in which four different oligonucleotide probes are fixed onto microwell plates hybridized separately with biotinylated PCR amplification products derived from clinical samples. The first probe capable of hybridizing all seven known HCV genotypes was used overall detection, the remaining were to recognize specifically 1–3. When combined an improved silica-based RNA extraction method, sensitivity...