Lei He

ORCID: 0000-0003-1540-3403
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About
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Research Areas
  • Prosthetics and Rehabilitation Robotics
  • Muscle activation and electromyography studies
  • Lower Extremity Biomechanics and Pathologies
  • Foot and Ankle Surgery
  • Tendon Structure and Treatment
  • Stroke Rehabilitation and Recovery
  • Occupational Health and Performance
  • Autoimmune and Inflammatory Disorders Research
  • Robot Manipulation and Learning
  • Sports injuries and prevention
  • Rheumatoid Arthritis Research and Therapies
  • Shoulder Injury and Treatment
  • Bone Tissue Engineering Materials
  • Nanoplatforms for cancer theranostics
  • Orthopedic Surgery and Rehabilitation
  • Nuclear Structure and Function
  • Peripheral Nerve Disorders
  • Bone and Joint Diseases
  • Extracellular vesicles in disease
  • MXene and MAX Phase Materials

Huazhong University of Science and Technology
2014-2024

Minzu University of China
2024

Minda Hospital
2024

Union Hospital
2020-2024

Angiogenesis and neurogenesis play irreplaceable roles in bone repair. Although biomaterial implantation that mimics native skeletal tissue is extensively studied, the nerve-vascular network reconstruction neglected design of biomaterials. Our goal here to establish a periosteum-simulating bilayer hydrogel explore efficiency repair via enhancement angiogenesis neurogenesis. In this contribution, we designed platform incorporated with magnesium-ion-modified black phosphorus (BP) nanosheets...

10.1016/j.bioactmat.2022.02.024 article EN cc-by-nc-nd Bioactive Materials 2022-02-28

Loaded walking with a rucksack results in both gravitational and inertial forces of the load that must be borne by human carriers. The force may source metabolic burden musculoskeletal injuries. This paper presents lightweight backpack disturbance observer-based acceleration control to minimize force. was evaluated seven participants on treadmill at 5 km h <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> 19.4 kg load. Three experimental...

10.1109/tnsre.2020.3011974 article EN IEEE Transactions on Neural Systems and Rehabilitation Engineering 2020-07-27

Osteonecrosis of the femoral head (ONFH) is a common complication glucocorticoid (GC) therapy. Recent advances demonstrate that sympathetic nerves regulate bone homeostasis, and GCs lower tone. Here, we show dramatically decreased tone closely associated with pathogenesis GC-induced ONFH. activate receptor (GR) but hinder activation mineralocorticoid (MR) on neurons in hypothalamic paraventricular nucleus (PVN). This disrupts balance corticosteroid receptors (GR/MR) subsequently reduces...

10.1038/s41413-024-00371-3 article EN cc-by Bone Research 2024-11-08

BACKGROUND It is challenging to entirely show the anterior talofibular ligament (ATFL) and accurately diagnose ATFL injury with traditional 2-dimensional (2D) magnetic resonance imaging (MRI). With introduction of 3.0T MRI, a 3-dimensional (3D) MRI sequence can achieve images high spatial resolution. This study aimed evaluate accuracy 3D compare it 2D in diagnosing injury. MATERIAL AND METHODS was prospective which 45 patients clinically suspected underwent model reconstruction followed by...

10.12659/msm.927920 article EN Medical Science Monitor 2021-01-16

BACKGROUND:Haglund's deformity is an abnormal bony enlargement on the back of heel. It can cause impact posterior calcaneal bursa and Achilles tendon insertion, finally result in pain. This syndrome called Haglund syndrome. The purpose this study was to explore effect suture anchor allogeneic treatment MATERIAL AND METHODS:We retrospectively studied 20 patients with treated from January 2015 December 2016. were randomly divided into Group 1 (the group) 2 group), 10 each group average...

10.12659/msm.927501 article EN Medical Science Monitor 2020-11-19

Abstract Background : Epithelial regeneration is an essential wound healing process, and recent work suggests that different types of exosomes (Exos) can be employed to improve repair outcomes by promoting such epithelial regeneration. Platelet-rich plasma (PRP) known facilitate enhanced healing, yet the mechanisms underlying its activity are poorly understood. Results We found PRP-derived (PRP-Exos) effectively promoted in vitro proliferation, migration, human immortalized keratinocytes...

10.21203/rs.3.rs-552400/v1 preprint EN cc-by Research Square (Research Square) 2021-06-08

The anterior talofibular ligament (ATFL) is the most vulnerable in ankle sprains. Most patients recover after this injury with conservative treatment, while 20%-40% progress to chronic instability that requires surgical stabilization. Conventional MRI does not provide a comprehensive image of ATFL. We aimed evaluate feasibility using 3D facilitate understanding ATFL injuries and operative planning.

10.3389/fspor.2024.1488082 article EN cc-by Frontiers in Sports and Active Living 2024-12-19
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