- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Musculoskeletal pain and rehabilitation
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Spinal Cord Injury Research
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Motor Control and Adaptation
- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Foot and Ankle Surgery
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Amino Acid Enzymes and Metabolism
- Peptidase Inhibition and Analysis
National Yang Ming Chiao Tung University
2016-2025
National Taipei University of Technology
2025
National Yang Ming University Hospital
2007-2022
Ministry of Science and Technology of the People's Republic of China
2022
National Taiwan University
2022
Council of Independent Colleges
2022
American Physical Therapy Association
2019
National Science and Technology Council
2015
Taipei Veterans General Hospital
2002-2015
Ministry of Education
2015
Objective: To examine the effectiveness of task-oriented progressive resistance strength training on lower extremity and functional performance in chronic stroke subjects. Design: Single-blind, randomized controlled trial. Setting: Medical centre district hospital. Subjects: Forty-eight subjects at least one year post stroke. Interventions: Participants randomly allocated to two groups, control (n-/24) experimental (n-/24). Subjects group did not receive any rehabilitation training. were put...
Background. Obstacle crossing is a balance-challenging task and can cause falls in people with Parkinson’s disease (PD). However, programs for PD that effectively target obstacle dynamic balance have not been established. Objective. To examine the effects of virtual reality–based exercise on performance participants PD. Methods. Thirty-six diagnosis (Hoehn Yahr score ranging 1 to 3) were randomly assigned one three groups. In groups, received Wii Fit (VRWii group) or traditional (TE 45...
The model of interhemispheric competition after stroke has been established for the upper but not lower extremity. Repetitive transcranial magnetic stimulation (rTMS) brain shown to modulate cortical excitability.The purpose this study was investigate effects rTMS followed by task-oriented training on excitability and walking performance in individuals with chronic stroke.A total 24 patients average Fugl-Meyer limb scores 17.88 ± 5.27 speeds 63.81 18.25 cm/s were randomized into an...
The present study examined the effects of a balance-based exergaming intervention using Kinect sensor on postural stability and balance in people with Parkinson's disease (PD). We conducted subject-blinded, randomized controlled study. Twenty PD (Hoehn Yahr stages I through III) were recruited randomly assigned to either group (N = 10) or training for an 8-week period. Postural was assessed limits (LOS) one-leg stance (OLS) tests. Balance Berg Scale (BBS) timed up go (TUG) test. Participants...
This study investigated effects of cognitive and motor dual task gait training on performance in stroke. Participants (n = 28) were randomly assigned to (CDTT), (MDTT), or conventional physical therapy (CPT) group. CDTT MDTT group practiced the tasks respectively during walking. CPT received strengthening, balance, training. The intervention was 30 min/session, 3 sessions/week for 4 weeks. Three test conditions evaluate single walking, walking while performing (serial subtraction),...
Objective: To examine the effectiveness of additional backward walking training on gait outcome patients post stroke. Design: Randomized controlled trial. Setting: Medical centre. Subjects: Twenty-five subjects with stroke, who were lower extremity Brunnstrom motor recovery stage at 3 or 4 and able to walk 11 m without a aid orthosis, randomly allocated two groups, control (n = 12) experimental 13). Interventions: Subjects in both groups participated 40 min conventional programme three times...
Background. Numerous studies have reported the effects of gait training on motor performance after stroke. However, there is limited information treatment-induced changes in corticomotor excitability. Objectives. The purpose study was to investigate additional and excitability demonstrate relationship between improvement change patients with chronic Methods. Fourteen were randomly assigned experimental or control group. Participants both groups participated general physical therapy. Those...
Objective: To examine the effects of an ankle-foot orthosis (AFO) on balance performance in patients with hemiparesis short and long duration. Design: Within-subject random order intervention, cross-sectional study design. Settings: Medical centres district hospitals. Subjects: Forty-two subjects duration (B=six months) 61 (=12 months). Measurements: The gait ability were evaluated both AFO without. static dynamic activities by Balance Master System, whereas functional was assessed Berg...
Objective: To determine the effectiveness of sit-to-stand training in individuals with stroke. Design: Randomized controlled trial. Setting: Rehabilitation medical centre. Participants: Thirty-two subjects stroke were randomly assigned to control and experimental groups (n = 16 for each group). Interventions: Subjects both received 30 minutes general physical therapy three times a week four weeks. group additional 15 time. The total amount was 45 Main outcome measures: weight-bearing...
Repetitive transcranial magnetic stimulation (rTMS) of the brain has been shown to modulate cortical excitability. Combinations rehabilitation therapies with rTMS might enhance therapeutic effects.The purpose this study was investigate effects high-frequency followed by treadmill training on inhibition and walking function in individuals Parkinson disease (PD).A total 20 patients PD were randomized into an experimental group a control group. Participants received (experimental group) or sham...
Background Memory impairment is a frequent complication of brain ischemia. Neurogenesis implicated in learning and memory regulated by the transcription factor c-Fos. Preconditioning intermittent hypoxia (IH) attenuates ischemia-related impairments, but it not known whether post-ischemia IH intervention has similar effect. We investigated effects on hippocampal neurogenesis c-Fos expression as well spatial rats. Methodology/Principal Findings Focal cerebral ischemia was induced some rats...
Gait impairments in Parkinson's disease (PD) are aggravated under dual task conditions. Providing effective training to enhance different gait performance is important for PD rehabilitation. This pilot study aimed investigate the effects of cognitive and motor on PD. Eighteen participants (n = 6 per group) were assigned (CDTT), (MDTT), or general (control) group randomly. The was 30 min each session, 3 sessions week 4 weeks. Primary outcomes including during task, single walking assessed at...
Adult hippocampal neurogenesis is important for learning and memory, especially after a brain injury such as ischemia. Newborn neurons contribute to memory performance by establishing functional synapses with target cells. This study demonstrated that the maturation of enhanced postischemia intermittent hypoxia (IH) intervention. The effects IH intervention in cultured were mediated increased synaptogenesis, which was primarily regulated brain-derived neurotrophic factor (BDNF)/PI3K/AKT....
Objective: We investigated the effects of a computer-generated interactive visual feedback training program on recovery from pusher syndrome in stroke patients. Design: Assessor-blinded, pilot randomized controlled study. Participants: A total 12 patients with were randomly assigned to either experimental group ( N = 7, training) or control 5, mirror training). Main outcome measures: The scale for contraversive pushing severity syndrome, Berg Balance Scale balance performance, and Fugl-Meyer...
This paper investigated the effects of cognitive and motor dual tasks on gait performance brain activities in stroke; 23 stroke subjects performed single walking (SW), while performing task (WCT), (WMT) at self-selected speed. The was recorded, including speed, cadence, stride time, length, cost (DTC). Brain prefrontal cortex, premotor cortex (PMC), supplementary areas (SMAs) were measured by functional near-infrared spectroscopy during walking. Results showed significant decrease increase...
Objective: Aging is associated with decline in executive function that may lead to reduced dual-task performance. Regular exercise has been recommended for promoting or maintaining mental and physical health older adults, yet only a fraction of adults regularly. Exergame training have the potential enhance adherence. Therefore, aim this study was examine effects exergame-based on performance community-dwelling adults. Materials Methods: This single-blinded, randomized-controlled trial....