A5045051245- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Retinoids in leukemia and cellular processes
- Cancer Genomics and Diagnostics
- Photochromic and Fluorescence Chemistry
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- Photoreceptor and optogenetics research
- Pharmaceutical Practices and Patient Outcomes
- Cancer-related gene regulation
- Patient Satisfaction in Healthcare
- Public Health in Brazil
- Autoimmune and Inflammatory Disorders
- vaccines and immunoinformatics approaches
- Oral Health Pathology and Treatment
- Healthcare Systems and Technology
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Cardiac and Coronary Surgery Techniques
- Retinopathy of Prematurity Studies
- Monoclonal and Polyclonal Antibodies Research
- bioluminescence and chemiluminescence research
Marshfield Clinic
2021-2022
University of Michigan
2013-2019
Hurley Medical Center
2018-2019
Michigan State University
2018-2019
McLaren Regional Medical Center
2019
Oakland University
2012-2014
Smith-Kettlewell Eye Research Institute
2012-2014
University of Rochester
2010-2011
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers aberrant DNA methylation. methyltransferase inhibitors (DMTis) used to treat these disorders, but response is highly variable, with few means predict which patients will benefit. Here, we examined baseline differences mutations, methylation, gene expression 40 CMML who were responsive or resistant decitabine (DAC) order develop a molecular of predicting...
Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and characterized by recurring structural genetic alterations. Previous studies of DNA methylation suggest epigenetic alterations may also be important, but an integrated genome-wide analysis in ALL has not been performed. We analyzed 137 B-lineage 30 T-lineage cases using microarray copy number gene expression, cytosine profiling HpaII tiny fragment enrichment ligation-mediated PCR (HELP) assay. found that different...
Telehealth at home (TAH) is a means of providing patient care that increasingly utilized by health organizations. It crucial to identify factors, such as internet accessibility, might impact the ability patients make use services.A retrospective analysis was conducted using real-time data from audio-visual telehealth encounters Cisco Webex Meetings platform April 22, 2020 May 26, 2020, and originating single rural system in state Wisconsin. Quality scores were determined for each encounter,...
Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in bone marrow. PML/RARA primary abnormality implicated this pathology, but mechanisms which chimeric fusion protein initiates disease are incompletely understood. Identifying targets vivo critical for comprehending road to pathogenesis. Utilizing a novel sorting strategy, we isolated highly purified promyelocyte populations from normal and young preleukemic animals, carried out...
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis occurring at rate of 3-10 per million/year in the general population, with higher frequency women. Roughly half patients have an associated medical condition, inflammatory bowel disease, hematologic disorders, and arthritis having strongest associations.1 Vulvovaginal involvement exceedingly rare, few cases reported literature. A recent connection between rituximab use vulvovaginal PG has been reported, successful treatment using...
Background: Metastatic clear-cell renal cell carcinoma (RCC) is largely incurable, and its treatment remains challenging. Sunitinib, a tyrosine kinase inhibitor, one of the current standard-of-care options for treatment-naïve patients with metastatic RCC. Despite proven efficacy sunitinib, prolonged some inhibitors (TKIs) has been associated significant adverse events (AEs). Therefore, we aimed to calculate exact prevalence all sunitinib-related AEs in pooled analysis from available...
e16067 Background: Metastatic clear-cell renal cell carcinoma (RCC) is largely incurable, and its treatment remains challenging. Sunitinib, a tyrosine kinase inhibitor, one of the current standard-of-care options for treatment-naïve patients with metastatic RCC. Despite proven efficacy prolonged some inhibitors (TKIs) has been associated significant adverse events (AEs). Therefore, we aimed to calculate exact in addition prevalence all AEs Sunitinib pooled analysis from available randomized...
Introduction Electronic medication reconciliation systems are known to reduce errors. We hypothesised that refinement of the electronic medical record (EMR) and provider education could improve adherence completion admission reconciliation, thereby potentially limiting prescribing Our goal was percentage patients with completed within 24 hours at least 90%. Methods A prospective interventional study conducted a university-affiliated community hospital between 1 January 2017 30 September...