A5003402407- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Nutritional Studies and Diet
- Atherosclerosis and Cardiovascular Diseases
- Neuroendocrine Tumor Research Advances
- Carbohydrate Chemistry and Synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Trypanosoma species research and implications
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Pancreatitis Pathology and Treatment
- RNA regulation and disease
- MicroRNA in disease regulation
- Fatty Acid Research and Health
- Diet and metabolism studies
- IgG4-Related and Inflammatory Diseases
- Cell Adhesion Molecules Research
- Diabetic Foot Ulcer Assessment and Management
- Glycogen Storage Diseases and Myoclonus
- Metabolism, Diabetes, and Cancer
- Biochemical and Molecular Research
- Acute Ischemic Stroke Management
- Lipoproteins and Cardiovascular Health
- Migraine and Headache Studies
- Immune Cell Function and Interaction
University of Palermo
2015-2024
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2023
University of Palermo
2016
Fondazione Istituto G. Giglio di Cefalù
2015
CD4+ CD28− T cells also called CD28 null have been reported as increased in the clinical setting of acute coronary syndrome. Only 2 studies previously analyzed peripheral frequency subjects with ischemic stroke but, to our knowledge, each TOAST subtype has never evaluated. We hypothesized that and, particular, cell subset could show a different degree percentage relation and severity stroke. The aim study was analyze diagnostic subtype, evaluate their relationship scores stroke, predictive...
Statins have beneficial effects on cerebral circulation and brain parenchyma during ischemic stroke reperfusion. The primary hypothesis of this randomized parallel trial was that treatment with 80 mg/day atorvastatin administered early at admission after acute atherosclerotic could reduce serum levels markers immune-inflammatory activation the phase modulation a possible effect prognosis evaluated by some outcome indicators. We enrolled 42 patients classified as large arteries...
Abstract Background Recent cardiovascular outcome trials have shown significant reductions in major (CV) events with glucagon-like peptide (GLP)-1 receptor agonists. Additionally, adjunctive surrogates for risk validated by some studies include arterial stiffness and endothelial function indexes. To date, no randomized trial has addressed the possible effects of antidiabetic interventional drugs such as GLP1 agonists on indexes surrogate markers vascular damage. Aims We aimed to evaluate...
In humans, a major component of natural killer (NK) and T cell target recognition depends on the surveillance human leukocyte antigen (HLA) class I molecules by immunoglobulin-like receptors (KIRs). To implement knowledge about immunological genetic background acute ischemic stroke susceptibility in relation to frequency KIR genes HLA alleles. Subjects with subjects without were genotyped for presence three ligand groups, HLA-C1, HLA-C2, HLA-Bw4, both HLA-B HLA-A loci. Between November 2013...
Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators vascular health. We aimed to assess whether the presence diabetic foot associated with function impairment.We studied 50 subjects type 2 diabetes mellitus syndrome (DFS) compared without foot, 53 patients mellitus, by means mini mental state examination (MMSE) administered evaluate cognitive performance. Carotid-femoral pulse wave velocity (PWV) augmentation...
Background : IgG4-related disease is a rare, clinical and pathologic entity of unknown etiology. Its main features are increased serum concentrations IgG4 > 1,35 g/l, lymphocyte IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation IgG4-RSD pancreatitis which combined with the involvement biliary ducts in 74 percent patients. Extrapancreatic manifestations include: abdominal mediastinal lymphadenopathy; salivary glands lacrimal glands, kidneys, lung,...
Anderson-Fabry disease (AFD) is an inborn lysosomal enzymopathy resulting from the deficient or absent activity of exogalactohydrolase, α-galactosidase A. This deficiency, results in altered metabolism glycosphingolipids which leads to their accumulation lysosomes, thus cellular and vascular dysfunction. To date, numerous mutations (according recent data more than 1000 mutations) have been reported GLA intronic exonic mutations. Traditionally, clinical manifestations are severe affected...
In recent years a growing body of evidence supported the role inflammation in initiation, maintenance and outcome atrial fibrillation (AF).Nevertheless, despite large amount information, whether AF or underlying structural heart disease (SHD) is cause inflammatory process still under debate.We, therefore, sought to determine if reflect an arrhythmia 'per se'.We evaluated plasma levels soluble Interleukin 2 Receptor Alpha (sIL-2Rα), TNF-α IL-18 100 consecutive patients with permanent AF, (43...
Fabry disease (FD) is a recessive monogenic linked to chromosome X due more than two hundred mutations in the alfa-galactosidase A (GLA) gene. Modifications of GLA gene may cause progressive accumulation globotriaosylceramide (Gb3) and its deacylated form, globotriasylsphingosine (lyso-Gb3), lysosomes several types cells heart, kidneys, skin, eyes, peripheral central nervous system (not clearly fully demonstrated), gut with different pleiotropic clinical symptoms. Among main symptoms are...
Abstract Background Fabry disease (FD) is an X-linked lysosomal storage disorder, caused by deficient activity of the alpha-galactosidase A enzyme leading to progressive and multisystemic accumulation globotriaosylceramide. Recent data point toward oxidative stress signalling which could play important role in both pathophysiology progression. Methods We have examined biomarkers [Advanced Oxidation Protein Products (AOPP), Ferric Reducing Antioxidant Power (FRAP), thiolic groups] blood...
No study has analyzed the prevalence of white matter hyperintensities (WMHs) in subjects with diabetic foot syndrome (DFS) and their relationship to adipokine serum levels indexes endothelial cognitive performance.To evaluate omentin vaspin WMHs DFS analyze other endothelial, arterial stiffness, functions.Case-control enrolling 40 DFS, without complications, controls lesions diabetes, patients diabetes mellitus.Pulse wave velocity (PWV), augmentation index, reactive hyperemia index (RHI),...